SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i6t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		3 / 3 TRP A 304
ALA A 413
VAL A 314
 None
 0.88A 1c4dA-2i6tA:
undetectable
1c4dB-2i6tA:
undetectable		 1c4dA-2i6tA:
4.23
1c4dB-2i6tA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		5 / 9 THR A 252
LEU A 193
VAL A 390
GLY A 391
VAL A 398
 None
 1.12A 1dz8B-2i6tA:
undetectable		 1dz8B-2i6tA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		5 / 9 THR A 252
LEU A 193
VAL A 390
GLY A 391
VAL A 398
 None
 1.13A 1dz9B-2i6tA:
undetectable		 1dz9B-2i6tA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		5 / 10 LEU A 210
VAL A 248
ILE A 401
VAL A 187
ILE A 185
 None
 0.98A 1hsgA-2i6tA:
undetectable		 1hsgA-2i6tA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		5 / 9 LEU A 210
VAL A 248
ILE A 401
VAL A 187
ILE A 185
 None
 1.00A 1ohrB-2i6tA:
undetectable		 1ohrB-2i6tA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		4 / 4 LEU A 276
LEU A 306
SER A 307
LEU A 289
 None
 1.10A 1ya3A-2i6tA:
undetectable		 1ya3A-2i6tA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		3 / 3 HIS A 463
ILE A 421
LEU A 414
 None
 0.44A 2kceA-2i6tA:
undetectable		 2kceA-2i6tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		5 / 12 LEU A 210
VAL A 248
ILE A 401
VAL A 187
ILE A 185
 None
 0.97A 2pynB-2i6tA:
undetectable		 2pynB-2i6tA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		5 / 10 VAL A 248
SER A 400
ASN A 320
VAL A 411
GLY A 316
 None
 1.39A 2x2iD-2i6tA:
undetectable		 2x2iD-2i6tA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		5 / 10 LEU A 210
VAL A 248
ILE A 401
VAL A 187
ILE A 185
 None
 0.97A 3em3B-2i6tA:
undetectable		 3em3B-2i6tA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		5 / 12 LEU A 210
VAL A 248
ILE A 401
VAL A 187
ILE A 185
 None
 0.97A 3em6B-2i6tA:
undetectable		 3em6B-2i6tA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		5 / 12 ILE A 317
LEU A 290
VAL A 248
ALA A 207
LEU A 210
 GOL  A   6 (-3.8A)
None
None
None
None
 1.37A 3ozuA-2i6tA:
5.6		 3ozuA-2i6tA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		5 / 12 LEU A 210
VAL A 248
ILE A 401
VAL A 187
ILE A 185
 None
 0.89A 3pwrB-2i6tA:
undetectable		 3pwrB-2i6tA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		5 / 9 LEU A 326
VAL A 343
LEU A 334
THR A 331
ILE A 330
 None
 1.20A 3tbgD-2i6tA:
undetectable		 3tbgD-2i6tA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		5 / 12 LEU A 210
VAL A 248
ILE A 401
VAL A 187
ILE A 185
 None
 0.87A 4dqbA-2i6tA:
undetectable		 4dqbA-2i6tA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		5 / 12 LEU A 210
VAL A 248
ILE A 401
VAL A 187
ILE A 185
 None
 0.93A 4dqfA-2i6tA:
undetectable		 4dqfA-2i6tA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		4 / 8 VAL A 288
ILE A 401
SER A 246
ALA A 207
 None
 0.97A 4eyzA-2i6tA:
undetectable		 4eyzA-2i6tA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		4 / 8 VAL A 288
ILE A 401
SER A 246
ALA A 207
 None
 0.98A 4eyzB-2i6tA:
undetectable		 4eyzB-2i6tA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		3 / 3 HIS A 463
VAL A 266
LEU A 469
 None
 0.64A 4m2vA-2i6tA:
undetectable		 4m2vA-2i6tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		3 / 3 LEU A 321
MET A 397
TYR A 328
 GOL  A   6 (-3.8A)
None
None
 0.85A 4p6xG-2i6tA:
undetectable		 4p6xG-2i6tA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		4 / 5 GLN A 466
LEU A 465
SER A 464
ASP A 420
 None
 1.35A 4qtuD-2i6tA:
7.4		 4qtuD-2i6tA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		4 / 8 ASN A 269
LEU A 276
VAL A 291
GLY A 190
 None
 0.76A 4r3aA-2i6tA:
undetectable		 4r3aA-2i6tA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		4 / 8 ASN A 269
LEU A 276
VAL A 291
GLY A 191
 None
 0.82A 4r3aA-2i6tA:
undetectable		 4r3aA-2i6tA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		5 / 12 VAL A 390
ILE A 317
GLY A 316
VAL A 288
LEU A 433
 None
GOL  A   6 (-3.8A)
None
None
None
 1.06A 4y8wA-2i6tA:
undetectable		 4y8wA-2i6tA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		5 / 12 VAL A 390
ILE A 317
GLY A 316
VAL A 288
LEU A 433
 None
GOL  A   6 (-3.8A)
None
None
None
 1.06A 4y8wB-2i6tA:
undetectable		 4y8wB-2i6tA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		5 / 12 ASP A 352
LEU A 446
ASP A 449
SER A 458
THR A 444
 None
None
None
None
GOL  A  11 (-3.8A)
 1.34A 5hnzB-2i6tA:
2.2		 5hnzB-2i6tA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		3 / 3 ASP A 399
ASN A 320
GLN A 324
 None
 0.81A 5k7uA-2i6tA:
undetectable		 5k7uA-2i6tA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		3 / 3 LEU A 306
VAL A 270
ASP A 271
 None
 0.61A 5x23A-2i6tA:
undetectable		 5x23A-2i6tA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens) 		5 / 12 LEU A 290
VAL A 187
LEU A 212
VAL A 248
ILE A 250
 None
 1.01A 6dgxB-2i6tA:
undetectable		 6dgxB-2i6tA:
14.54