SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i6v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2i6v GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		5 / 12 LEU A 264
LEU A 269
ALA A 261
VAL A 241
PHE A 250
 None
 1.09A 3b0wA-2i6vA:
undetectable		 3b0wA-2i6vA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 2i6v GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		4 / 6 LEU A 267
ALA A 263
SER A 289
THR A 291
 None
 0.98A 3cfqA-2i6vA:
undetectable		 3cfqA-2i6vA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 2i6v GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		4 / 7 LEU A 267
ALA A 263
SER A 289
THR A 291
 None
 1.03A 3cfqA-2i6vA:
undetectable
3cfqB-2i6vA:
undetectable		 3cfqA-2i6vA:
18.10
3cfqB-2i6vA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 2i6v GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		4 / 6 LEU A 267
ALA A 263
SER A 289
THR A 291
 None
 0.99A 4ikiB-2i6vA:
undetectable		 4ikiB-2i6vA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 2i6v GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		4 / 7 LEU A 267
ALA A 263
SER A 289
THR A 291
 None
 0.94A 4ikjA-2i6vA:
undetectable
4ikjB-2i6vA:
undetectable		 4ikjA-2i6vA:
17.32
4ikjB-2i6vA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2i6v GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		4 / 8 LEU A 267
ALA A 263
SER A 289
THR A 291
 None
 0.93A 4ikjA-2i6vA:
undetectable
4ikjB-2i6vA:
undetectable		 4ikjA-2i6vA:
17.32
4ikjB-2i6vA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2i6v GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		4 / 8 LEU A 267
ALA A 263
SER A 289
THR A 291
 None
 0.97A 4ikkA-2i6vA:
undetectable
4ikkB-2i6vA:
undetectable		 4ikkA-2i6vA:
17.32
4ikkB-2i6vA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 2i6v GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		4 / 7 LEU A 267
ALA A 263
SER A 289
THR A 291
 None
 0.95A 4ikkA-2i6vA:
undetectable
4ikkB-2i6vA:
undetectable		 4ikkA-2i6vA:
17.32
4ikkB-2i6vA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 2i6v GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		4 / 6 ASP A 259
ARG A 294
GLY A 296
HIS A 299
 None
 1.09A 4oltB-2i6vA:
undetectable		 4oltB-2i6vA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2i6v GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		3 / 3 SER A 289
ALA A 263
VAL A 262
 None
 0.64A 4x20C-2i6vA:
undetectable		 4x20C-2i6vA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2i6v GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		4 / 4 LEU A 267
MET A 275
VAL A 274
ASN A 273
 None
 1.39A 5b8iB-2i6vA:
undetectable		 5b8iB-2i6vA:
23.39