SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i6x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
3 / 3 GLN A 207
TYR A 102
ARG A 103
None
0.84A 1gtbA-2i6xA:
undetectable
1gtbA-2i6xA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
4 / 7 PHE A 153
PRO A 148
ALA A 180
PHE A 169
None
1.21A 1lqtA-2i6xA:
undetectable
1lqtA-2i6xA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
4 / 7 PHE A 153
PRO A 148
ALA A 180
PHE A 169
None
1.21A 1lquA-2i6xA:
undetectable
1lquA-2i6xA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
5 / 9 PHE A  92
GLY A  10
THR A 110
LEU A 115
LEU A 130
None
1.16A 1nr6A-2i6xA:
undetectable
1nr6A-2i6xA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
4 / 4 LEU A 106
PRO A 125
ILE A  14
LEU A  13
None
1.03A 1ya4C-2i6xA:
undetectable
1ya4C-2i6xA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
4 / 4 GLY A  10
SER A 108
VAL A 114
LEU A  16
None
1.15A 1yajB-2i6xA:
undetectable
1yajB-2i6xA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
5 / 8 LEU A 106
PHE A   7
PHE A 134
LEU A 130
PHE A 123
None
1.44A 2eilP-2i6xA:
undetectable
2eilW-2i6xA:
undetectable
2eilP-2i6xA:
20.30
2eilW-2i6xA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
4 / 5 PHE A   7
PHE A 134
LEU A 130
PHE A 123
None
1.21A 2y69C-2i6xA:
undetectable
2y69J-2i6xA:
undetectable
2y69C-2i6xA:
20.30
2y69J-2i6xA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
4 / 5 PHE A   7
PHE A 134
LEU A 130
PHE A 123
None
1.27A 2y69P-2i6xA:
undetectable
2y69W-2i6xA:
undetectable
2y69P-2i6xA:
20.30
2y69W-2i6xA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
5 / 6 LEU A 106
PHE A   7
PHE A 134
LEU A 130
PHE A 123
None
1.43A 3abkP-2i6xA:
undetectable
3abkW-2i6xA:
undetectable
3abkP-2i6xA:
20.30
3abkW-2i6xA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
4 / 5 PHE A   7
PHE A 134
LEU A 130
PHE A 123
None
1.22A 3abmC-2i6xA:
undetectable
3abmJ-2i6xA:
undetectable
3abmC-2i6xA:
20.30
3abmJ-2i6xA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
4 / 5 PHE A   7
PHE A 134
LEU A 130
PHE A 123
None
1.21A 3abmP-2i6xA:
undetectable
3abmW-2i6xA:
undetectable
3abmP-2i6xA:
20.30
3abmW-2i6xA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
4 / 5 PHE A   7
PHE A 134
LEU A 130
PHE A 123
None
1.20A 3ag3C-2i6xA:
undetectable
3ag3J-2i6xA:
undetectable
3ag3C-2i6xA:
20.30
3ag3J-2i6xA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
5 / 8 LEU A 106
PHE A   7
PHE A 134
LEU A 130
PHE A 123
None
1.40A 3asoC-2i6xA:
undetectable
3asoJ-2i6xA:
undetectable
3asoC-2i6xA:
20.30
3asoJ-2i6xA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
4 / 8 ASN A 176
THR A 179
LEU A 183
ASN A 109
None
1.04A 3kp2A-2i6xA:
undetectable
3kp2B-2i6xA:
undetectable
3kp2A-2i6xA:
23.39
3kp2B-2i6xA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
4 / 8 ASN A 192
ASP A   8
SER A 108
GLU A  50
None
1.00A 3sg9B-2i6xA:
undetectable
3sg9B-2i6xA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA503_0
(OXIDOREDUCTASE,
FMN-BINDING)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
4 / 6 TRP A 196
PHE A   7
PHE A 134
PHE A  92
None
1.21A 4awuA-2i6xA:
0.3
4awuA-2i6xA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
5 / 8 ARG A 103
ASP A   8
ASP A 171
PRO A 164
THR A 167
None
1.45A 4eyrB-2i6xA:
undetectable
4eyrB-2i6xA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
5 / 12 ASP A 172
LEU A  37
GLY A  11
GLY A  10
ASN A 176
None
0.85A 4n09D-2i6xA:
4.1
4n09D-2i6xA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
4 / 8 PHE A  46
LEU A  80
TYR A 113
LEU A  63
None
0.82A 4qopC-2i6xA:
undetectable
4qopC-2i6xA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
5 / 7 LEU A 106
PHE A   7
PHE A 134
LEU A 130
PHE A 123
None
1.43A 5b1aC-2i6xA:
undetectable
5b1aJ-2i6xA:
undetectable
5b1aC-2i6xA:
20.30
5b1aJ-2i6xA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
5 / 7 LEU A 106
PHE A   7
PHE A 134
LEU A 130
PHE A 123
None
1.43A 5b1aP-2i6xA:
undetectable
5b1aW-2i6xA:
undetectable
5b1aP-2i6xA:
20.30
5b1aW-2i6xA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
5 / 7 LEU A 106
PHE A   7
PHE A 134
LEU A 130
PHE A 123
None
1.50A 5b3sC-2i6xA:
undetectable
5b3sJ-2i6xA:
undetectable
5b3sC-2i6xA:
20.30
5b3sJ-2i6xA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
5 / 7 LEU A 106
PHE A   7
PHE A 134
LEU A 130
PHE A 123
None
1.43A 5iy5C-2i6xA:
undetectable
5iy5J-2i6xA:
undetectable
5iy5C-2i6xA:
20.45
5iy5J-2i6xA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
4 / 5 PHE A   7
PHE A 134
LEU A 130
PHE A 123
None
1.21A 5wauC-2i6xA:
undetectable
5wauJ-2i6xA:
undetectable
5wauC-2i6xA:
20.30
5wauJ-2i6xA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
4 / 5 PHE A   7
PHE A 134
LEU A 130
PHE A 123
None
1.20A 5wauc-2i6xA:
undetectable
5wauj-2i6xA:
undetectable
5wauc-2i6xA:
20.30
5wauj-2i6xA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
4 / 5 PHE A   7
PHE A 134
LEU A 130
PHE A 123
None
1.19A 5xdqC-2i6xA:
undetectable
5xdqJ-2i6xA:
undetectable
5xdqC-2i6xA:
20.30
5xdqJ-2i6xA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
4 / 5 PHE A   7
PHE A 134
LEU A 130
PHE A 123
None
1.22A 5xdqP-2i6xA:
undetectable
5xdqW-2i6xA:
undetectable
5xdqP-2i6xA:
20.30
5xdqW-2i6xA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis)
5 / 7 LEU A 106
PHE A   7
PHE A 134
LEU A 130
PHE A 123
None
1.37A 5z84C-2i6xA:
undetectable
5z84J-2i6xA:
undetectable
5z84C-2i6xA:
20.30
5z84J-2i6xA:
16.34