SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i71'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 2i71 HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		4 / 6 LEU A 176
ILE A  81
TYR A  15
VAL A   5
 None
 1.02A 1db1A-2i71A:
undetectable		 1db1A-2i71A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 2i71 HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		4 / 4 HIS A 109
VAL A  86
THR A 104
LEU A 136
 MG  A 402 ( 4.8A)
MG  A 402 (-3.9A)
None
None
 1.35A 1oq5A-2i71A:
undetectable		 1oq5A-2i71A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2i71 HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		4 / 8 ILE A  22
SER A  29
ASP A 125
TYR A 161
 None
 1.13A 2zw9B-2i71A:
1.8		 2zw9B-2i71A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2i71 HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 ILE A  51
GLY A  50
ILE A 130
ALA A  88
VAL A 262
 None
 0.93A 3fpjA-2i71A:
2.3		 3fpjA-2i71A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 2i71 HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 LYS A 191
SER A 280
ILE A 279
LEU A 223
TYR A 107
 None
 1.39A 3ia4A-2i71A:
undetectable		 3ia4A-2i71A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2i71 HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 ILE A  48
GLN A 142
LEU A 114
VAL A  46
THR A 126
 None
 1.00A 3ix9A-2i71A:
undetectable		 3ix9A-2i71A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 2i71 HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		4 / 8 ILE A 130
SER A   7
GLY A 129
SER A  32
 None
 0.97A 3lslA-2i71A:
undetectable
3lslD-2i71A:
undetectable		 3lslA-2i71A:
22.14
3lslD-2i71A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 2i71 HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		5 / 11 ILE A 113
ILE A 106
ILE A   4
ALA A 137
VAL A  86
 None
None
None
None
MG  A 402 (-3.9A)
 1.07A 3tmzA-2i71A:
undetectable		 3tmzA-2i71A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2i71 HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		4 / 6 SER A 272
THR A 194
ILE A 197
PHE A 276
 None
 0.92A 4acbC-2i71A:
undetectable		 4acbC-2i71A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2i71 HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		4 / 6 ILE A 216
ILE A 279
SER A 236
PHE A 209
 None
 0.94A 4m51A-2i71A:
undetectable		 4m51A-2i71A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 2i71 HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 TYR A 107
ALA A 140
PHE A   6
VAL A 145
ILE A 119
 None
 1.12A 4uw0A-2i71A:
undetectable		 4uw0A-2i71A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2i71 HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 GLY A 352
THR A 353
GLU A 372
ILE A 373
ILE A 341
 None
 1.10A 4zvmA-2i71A:
undetectable
4zvmB-2i71A:
3.0		 4zvmA-2i71A:
21.18
4zvmB-2i71A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 2i71 HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 ALA A 220
LEU A 275
LEU A 271
LEU A 143
LEU A 190
 None
 0.92A 5toaA-2i71A:
undetectable		 5toaA-2i71A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2i71 HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 GLY A 226
LYS A 369
ASP A 368
GLY A 367
LEU A 325
 None
 1.14A 5wwsA-2i71A:
undetectable		 5wwsA-2i71A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2i71 HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		4 / 5 TYR A 354
LEU A 326
GLU A 328
TYR A 329
 None
 1.38A 6cbdA-2i71A:
2.8		 6cbdA-2i71A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2i71 HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 LEU A 114
ILE A 119
GLY A 118
VAL A  46
ILE A   4
 None
 0.89A 6emuA-2i71A:
undetectable		 6emuA-2i71A:
22.56