SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i75'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 2i75 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 4
(Homo
sapiens) 		3 / 3 ASN A 683
ASN A 706
ARG A 891
 None
 0.71A 2rlcA-2i75A:
undetectable		 2rlcA-2i75A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 2i75 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 4
(Homo
sapiens) 		3 / 3 ILE A 895
VAL A 884
ARG A 888
 None
 0.75A 3p73A-2i75A:
undetectable		 3p73A-2i75A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2i75 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 4
(Homo
sapiens) 		5 / 12 TYR A 709
GLN A 739
LEU A 698
VAL A 696
ILE A 705
 None
 1.14A 4k39A-2i75A:
undetectable		 4k39A-2i75A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 2i75 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 4
(Homo
sapiens) 		4 / 5 GLN A 744
ILE A 724
ILE A 705
TYR A 709
 None
 1.26A 5dnvA-2i75A:
undetectable		 5dnvA-2i75A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2i75 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 4
(Homo
sapiens) 		4 / 5 ARG A 891
CYH A 852
GLN A 727
ILE A 856
 None
SO4  A   1 ( 4.2A)
None
None
 1.49A 5ki6A-2i75A:
0.0		 5ki6A-2i75A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 2i75 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 4
(Homo
sapiens) 		5 / 9 ILE A 714
TYR A 723
ILE A 883
ALA A 868
LEU A 871
 None
 1.00A 5mvmA-2i75A:
undetectable
5mvmE-2i75A:
undetectable		 5mvmA-2i75A:
11.99
5mvmE-2i75A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 2i75 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 4
(Homo
sapiens) 		5 / 6 ILE A 883
ALA A 868
LEU A 871
ILE A 714
TYR A 723
 None
 1.01A 5mvmB-2i75A:
undetectable
5mvmC-2i75A:
undetectable		 5mvmB-2i75A:
11.99
5mvmC-2i75A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2i75 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 4
(Homo
sapiens) 		3 / 3 LEU A 871
ILE A 714
TYR A 723
 None
 0.69A 5uunB-2i75A:
undetectable		 5uunB-2i75A:
22.12