SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i76'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 2i76 HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		4 / 5 LEU A  16
ILE A  28
LEU A  29
SER A  30
 None
None
None
NDP  A 301 (-2.7A)
 1.00A 2byoA-2i76A:
undetectable		 2byoA-2i76A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2i76 HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		4 / 5 PRO A 105
ILE A 103
GLY A 125
TYR A 158
 NDP  A 301 (-4.0A)
None
None
None
 1.06A 2jkjD-2i76A:
undetectable		 2jkjD-2i76A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2i76 HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		4 / 5 PRO A 105
ILE A 103
GLY A 125
TYR A 158
 NDP  A 301 (-4.0A)
None
None
None
 1.06A 2jkjF-2i76A:
undetectable		 2jkjF-2i76A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2i76 HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A  26
GLY A  45
ALA A  47
LEU A  29
VAL A   2
 None
 0.99A 2zulA-2i76A:
undetectable		 2zulA-2i76A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2i76 HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A  26
GLY A  45
ALA A  47
LEU A  29
VAL A   2
 None
 0.97A 3dmhA-2i76A:
3.5		 3dmhA-2i76A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR5_A_SRYA1860_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 2i76 HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		3 / 3 LYS A  52
PRO A  54
LYS A  46
 None
 1.36A 4dr5L-2i76A:
undetectable		 4dr5L-2i76A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR6_A_SRYA1956_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 2i76 HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		3 / 3 LYS A  52
PRO A  54
LYS A  46
 None
 1.34A 4dr6L-2i76A:
0.0		 4dr6L-2i76A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 2i76 HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		3 / 3 LYS A  52
PRO A  54
LYS A  46
 None
 1.49A 4duzL-2i76A:
undetectable		 4duzL-2i76A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 2i76 HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		3 / 3 LYS A  52
PRO A  54
LYS A  46
 None
 1.34A 4dv7L-2i76A:
undetectable		 4dv7L-2i76A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 2i76 HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 12 PHE A 124
GLY A 128
ASP A 129
ARG A 100
ALA A 140
 None
 1.04A 5h5fA-2i76A:
undetectable		 5h5fA-2i76A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 2i76 HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		4 / 5 ARG A 100
SER A  92
SER A  91
SER A 152
 None
 1.17A 5hswA-2i76A:
undetectable		 5hswA-2i76A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 2i76 HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A  83
LEU A  76
ILE A  28
LEU A  29
LEU A   3
 None
 1.22A 5toaB-2i76A:
undetectable		 5toaB-2i76A:
21.11