SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i79'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 2i79 ACETYLTRANSFERASE,
GNAT FAMILY
(Streptococcus
pneumoniae) 		5 / 12 PHE A 144
TYR A 139
GLY A 168
LEU A 121
ALA A 111
 None
ACO  A 402 (-4.7A)
None
None
None
 1.47A 1e3vA-2i79A:
undetectable		 1e3vA-2i79A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_B_DXCB801_0
(STEROID
DELTA-ISOMERASE)		 2i79 ACETYLTRANSFERASE,
GNAT FAMILY
(Streptococcus
pneumoniae) 		5 / 11 PHE A 144
TYR A 139
GLY A 168
LEU A 121
ALA A 111
 None
ACO  A 402 (-4.7A)
None
None
None
 1.47A 1e3vB-2i79A:
0.3		 1e3vB-2i79A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 2i79 ACETYLTRANSFERASE,
GNAT FAMILY
(Streptococcus
pneumoniae) 		5 / 12 LEU A 121
LEU A 124
LEU A  90
ILE A  76
ILE A  60
 None
 1.06A 2bdmA-2i79A:
undetectable		 2bdmA-2i79A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 2i79 ACETYLTRANSFERASE,
GNAT FAMILY
(Streptococcus
pneumoniae) 		5 / 10 TYR A 139
LEU A 138
ILE A 112
ILE A  76
PHE A 144
 ACO  A 402 (-4.7A)
ACO  A 402 ( 4.5A)
None
None
None
 1.08A 3kz7A-2i79A:
undetectable		 3kz7A-2i79A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2i79 ACETYLTRANSFERASE,
GNAT FAMILY
(Streptococcus
pneumoniae) 		5 / 9 LEU A  41
ILE A  92
LEU A  90
ILE A  76
ILE A  60
 None
ACO  A 402 (-4.7A)
None
None
None
 1.00A 3zosB-2i79A:
undetectable		 3zosB-2i79A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2i79 ACETYLTRANSFERASE,
GNAT FAMILY
(Streptococcus
pneumoniae) 		5 / 11 LEU A 107
LEU A  66
ILE A  70
ILE A  94
TYR A  98
 None
None
None
ACO  A 402 (-4.1A)
None
 1.33A 4a7aA-2i79A:
undetectable		 4a7aA-2i79A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2i79 ACETYLTRANSFERASE,
GNAT FAMILY
(Streptococcus
pneumoniae) 		6 / 12 LEU A 107
LEU A 103
LEU A  66
ILE A  70
ILE A  94
TYR A  98
 None
ACO  A 402 (-4.9A)
None
None
ACO  A 402 (-4.1A)
None
 1.49A 4a7aB-2i79A:
undetectable		 4a7aB-2i79A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 2i79 ACETYLTRANSFERASE,
GNAT FAMILY
(Streptococcus
pneumoniae) 		5 / 8 LEU A  90
ALA A 111
ILE A 112
LEU A 121
SER A 118
 None
 1.44A 4wboB-2i79A:
undetectable		 4wboB-2i79A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2i79 ACETYLTRANSFERASE,
GNAT FAMILY
(Streptococcus
pneumoniae) 		3 / 3 ASP A  89
GLU A 147
SER A  56
 None
 0.80A 5bw4B-2i79A:
undetectable		 5bw4B-2i79A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 2i79 ACETYLTRANSFERASE,
GNAT FAMILY
(Streptococcus
pneumoniae) 		5 / 11 TYR A 139
LEU A 138
ILE A 112
ILE A  76
PHE A 144
 ACO  A 402 (-4.7A)
ACO  A 402 ( 4.5A)
None
None
None
 1.11A 5d75A-2i79A:
undetectable		 5d75A-2i79A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 2i79 ACETYLTRANSFERASE,
GNAT FAMILY
(Streptococcus
pneumoniae) 		5 / 11 TYR A 139
LEU A 138
ILE A 112
ILE A  76
PHE A 144
 ACO  A 402 (-4.7A)
ACO  A 402 ( 4.5A)
None
None
None
 1.08A 5gpgA-2i79A:
undetectable		 5gpgA-2i79A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2i79 ACETYLTRANSFERASE,
GNAT FAMILY
(Streptococcus
pneumoniae) 		5 / 9 ALA A 115
GLN A 116
GLU A 110
LEU A  90
ILE A  76
 None
 1.44A 5i73A-2i79A:
undetectable		 5i73A-2i79A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2i79 ACETYLTRANSFERASE,
GNAT FAMILY
(Streptococcus
pneumoniae) 		4 / 6 ASP A  79
ASN A  58
ASN A  75
GLN A  53
 None
 1.24A 5l6eA-2i79A:
undetectable		 5l6eA-2i79A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 2i79 ACETYLTRANSFERASE,
GNAT FAMILY
(Streptococcus
pneumoniae) 		5 / 12 LEU A  90
LEU A 126
GLY A 168
VAL A 145
LEU A 138
 None
ACO  A 402 (-4.1A)
None
None
ACO  A 402 ( 4.5A)
 0.95A 5uc1A-2i79A:
undetectable		 5uc1A-2i79A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 2i79 ACETYLTRANSFERASE,
GNAT FAMILY
(Streptococcus
pneumoniae) 		5 / 12 LEU A  90
LEU A 126
GLY A 168
VAL A 145
LEU A 138
 None
ACO  A 402 (-4.1A)
None
None
ACO  A 402 ( 4.5A)
 0.94A 5uc1B-2i79A:
undetectable		 5uc1B-2i79A:
19.16