SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i7a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 2i7a CALPAIN 13
(Homo
sapiens) 		4 / 6 PHE A 634
ALA A 595
LEU A 602
THR A 599
 None
 1.02A 4dtzA-2i7aA:
undetectable		 4dtzA-2i7aA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 2i7a CALPAIN 13
(Homo
sapiens) 		5 / 12 ILE A 516
LEU A 566
PHE A 563
VAL A 547
ALA A 548
 None
 1.25A 4fqsA-2i7aA:
undetectable		 4fqsA-2i7aA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDM_A_ADNA904_1
(ATP-CITRATE SYNTHASE)		 2i7a CALPAIN 13
(Homo
sapiens) 		4 / 4 THR A 599
ASP A 600
ARG A 603
LEU A 602
 None
 1.49A 5tdmA-2i7aA:
undetectable		 5tdmA-2i7aA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2i7a CALPAIN 13
(Homo
sapiens) 		4 / 4 LEU A 566
LEU A 521
SER A 545
ALA A 518
 None
 1.05A 5uunA-2i7aA:
undetectable		 5uunA-2i7aA:
19.32