SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		5 / 10 GLY A 439
PHE A 443
LEU A 559
PHE A 456
LEU A 549
 None
 1.13A 1a8uA-2i7nA:
undetectable		 1a8uA-2i7nA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		5 / 10 GLY A 439
PHE A 443
LEU A 559
PHE A 456
LEU A 549
 None
 1.11A 1a8uB-2i7nA:
undetectable		 1a8uB-2i7nA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		4 / 8 LEU A 277
ILE A 273
LEU A 250
HIS A 308
 None
 0.90A 2azxA-2i7nA:
undetectable		 2azxA-2i7nA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		4 / 8 GLU A 384
PHE A 582
VAL A 251
TYR A 581
 None
 1.17A 2fl5E-2i7nA:
undetectable
2fl5F-2i7nA:
undetectable		 2fl5E-2i7nA:
21.21
2fl5F-2i7nA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		5 / 9 THR A 442
GLY A 445
LEU A 450
LEU A 438
THR A 521
 None
 1.19A 2npnA-2i7nA:
2.3		 2npnA-2i7nA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		4 / 7 ARG A 311
PHE A 312
ILE A 310
PHE A 320
 None
 1.09A 2q6hA-2i7nA:
undetectable		 2q6hA-2i7nA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		4 / 7 ILE A 243
PHE A 312
ILE A 310
PHE A 320
 None
 1.07A 2q6hA-2i7nA:
undetectable		 2q6hA-2i7nA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		4 / 7 ILE A 243
PHE A 312
ILE A 310
PHE A 320
 None
 1.06A 2qb4A-2i7nA:
undetectable		 2qb4A-2i7nA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		5 / 7 VAL A 419
ALA A 530
VAL A 413
GLY A 435
THR A 436
 None
None
None
ACO  A 796 ( 4.2A)
None
 1.19A 2xrzB-2i7nA:
1.9		 2xrzB-2i7nA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		5 / 7 VAL A 419
ILE A 526
ALA A 530
GLY A 435
THR A 436
 None
None
None
ACO  A 796 ( 4.2A)
None
 1.11A 2xrzB-2i7nA:
1.9		 2xrzB-2i7nA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		5 / 12 GLY A 440
ALA A 515
ALA A 463
LEU A 549
LEU A 460
 None
 1.02A 3mteB-2i7nA:
undetectable		 3mteB-2i7nA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		5 / 12 GLY A 440
ALA A 515
ALA A 463
LEU A 549
LEU A 460
 None
 1.03A 3p2kA-2i7nA:
2.3		 3p2kA-2i7nA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		5 / 12 GLY A 440
ALA A 515
ALA A 463
LEU A 549
LEU A 460
 None
 1.08A 3p2kC-2i7nA:
undetectable		 3p2kC-2i7nA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		5 / 12 GLY A 440
ALA A 515
ALA A 463
LEU A 549
LEU A 460
 None
 1.02A 3p2kD-2i7nA:
undetectable		 3p2kD-2i7nA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		4 / 7 LEU A 460
GLY A 440
GLY A 439
ILE A 526
 None
 0.62A 4yjiA-2i7nA:
undetectable		 4yjiA-2i7nA:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		4 / 7 GLY A 418
SER A 420
ARG A 432
GLY A 435
 ACO  A 796 (-3.2A)
ACO  A 796 (-2.8A)
ACO  A 796 (-3.2A)
ACO  A 796 ( 4.2A)
 0.28A 5e26A-2i7nA:
23.0
5e26B-2i7nA:
40.9		 5e26A-2i7nA:
83.06
5e26B-2i7nA:
83.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		4 / 7 GLY A 418
SER A 420
ARG A 432
GLY A 435
 ACO  A 796 (-3.2A)
ACO  A 796 (-2.8A)
ACO  A 796 (-3.2A)
ACO  A 796 ( 4.2A)
 0.22A 5e26A-2i7nA:
23.0
5e26B-2i7nA:
40.9		 5e26A-2i7nA:
83.06
5e26B-2i7nA:
83.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		4 / 7 GLY A 418
SER A 420
ARG A 432
GLY A 435
 ACO  A 796 (-3.2A)
ACO  A 796 (-2.8A)
ACO  A 796 (-3.2A)
ACO  A 796 ( 4.2A)
 0.24A 5e26C-2i7nA:
41.0
5e26D-2i7nA:
41.4		 5e26C-2i7nA:
83.06
5e26D-2i7nA:
83.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		4 / 8 GLY A 418
SER A 420
ARG A 432
GLY A 435
 ACO  A 796 (-3.2A)
ACO  A 796 (-2.8A)
ACO  A 796 (-3.2A)
ACO  A 796 ( 4.2A)
 0.23A 5e26C-2i7nA:
41.0
5e26D-2i7nA:
41.4		 5e26C-2i7nA:
83.06
5e26D-2i7nA:
83.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		4 / 5 GLY A 418
SER A 420
ARG A 432
GLY A 435
 ACO  A 796 (-3.2A)
ACO  A 796 (-2.8A)
ACO  A 796 (-3.2A)
ACO  A 796 ( 4.2A)
 0.25A 5kprA-2i7nA:
41.2		 5kprA-2i7nA:
76.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		3 / 3 SER A 426
TYR A 425
TYR A 408
 None
 0.81A 5lakA-2i7nA:
undetectable
5lakI-2i7nA:
undetectable		 5lakA-2i7nA:
21.08
5lakI-2i7nA:
1.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		3 / 3 SER A 426
TYR A 425
TYR A 408
 None
 0.87A 5lakC-2i7nA:
undetectable
5lakJ-2i7nA:
undetectable		 5lakC-2i7nA:
21.08
5lakJ-2i7nA:
1.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		4 / 8 LEU A 412
VAL A 543
VAL A 545
ASP A 375
 None
 0.61A 5y9mA-2i7nA:
undetectable		 5y9mA-2i7nA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2i7n PANTOTHENATE KINASE
1
(Homo
sapiens) 		4 / 8 LEU A 412
VAL A 543
VAL A 545
ASP A 375
 None
 0.67A 5y9mX-2i7nA:
undetectable		 5y9mX-2i7nA:
13.06