SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i7p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		5 / 10 GLY A 214
PHE A 218
LEU A 334
PHE A 231
LEU A 324
 None
 1.07A 1a8uA-2i7pA:
undetectable		 1a8uA-2i7pA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		5 / 10 GLY A 214
PHE A 218
LEU A 334
PHE A 231
LEU A 324
 None
 1.07A 1a8uB-2i7pA:
undetectable		 1a8uB-2i7pA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		5 / 12 CYH A 222
ILE A 190
PHE A 218
GLY A 214
THR A 211
 None
 1.48A 1g60B-2i7pA:
undetectable		 1g60B-2i7pA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		5 / 9 ALA A 335
ASP A 339
GLY A 302
ILE A 301
VAL A 318
 None
 1.09A 1hpvB-2i7pA:
undetectable		 1hpvB-2i7pA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		3 / 3 PHE A 323
LEU A 294
MET A 237
 None
 0.91A 1mx1D-2i7pA:
undetectable		 1mx1D-2i7pA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		5 / 10 ALA A 335
ASP A 339
GLY A 302
ILE A 301
VAL A 318
 None
 0.95A 1t3rA-2i7pA:
undetectable		 1t3rA-2i7pA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		5 / 9 THR A 217
GLY A 220
LEU A 225
LEU A 213
THR A 296
 None
 1.20A 2npnA-2i7pA:
2.3		 2npnA-2i7pA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		5 / 7 VAL A 194
ALA A 305
VAL A 188
GLY A 210
THR A 211
 None
None
None
ACO  A1604 ( 3.9A)
None
 1.18A 2xrzB-2i7pA:
undetectable		 2xrzB-2i7pA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		5 / 7 VAL A 194
ILE A 301
ALA A 305
GLY A 210
THR A 211
 None
None
None
ACO  A1604 ( 3.9A)
None
 1.09A 2xrzB-2i7pA:
undetectable		 2xrzB-2i7pA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		6 / 12 LEU A 364
GLY A 361
GLY A 358
LEU A 136
ILE A 149
LEU A 363
 None
 1.23A 3cjtO-2i7pA:
undetectable		 3cjtO-2i7pA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		5 / 12 ALA A 362
ILE A  18
PHE A  14
ILE A  96
PRO A  93
 None
 1.17A 3clbB-2i7pA:
undetectable		 3clbB-2i7pA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		4 / 8 ASN A 322
LEU A 235
SER A 330
ASN A 189
 ACO  A1604 (-4.2A)
None
None
ACO  A1604 ( 4.9A)
 1.16A 3kp2A-2i7pA:
undetectable
3kp2B-2i7pA:
undetectable		 3kp2A-2i7pA:
17.24
3kp2B-2i7pA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		4 / 8 LEU A 139
ALA A 362
THR A 114
GLY A 321
 None
 0.92A 3ny4A-2i7pA:
undetectable		 3ny4A-2i7pA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		5 / 12 GLY A 215
ALA A 290
ALA A 238
LEU A 324
LEU A 235
 None
 0.92A 3p2kA-2i7pA:
undetectable		 3p2kA-2i7pA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		5 / 12 GLY A 302
ALA A 305
ALA A 309
LEU A 186
LEU A 334
 None
 1.15A 3p5nA-2i7pA:
undetectable		 3p5nA-2i7pA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		5 / 12 GLY A 302
ALA A 305
ALA A 309
LEU A 186
LEU A 334
 None
 1.14A 3p5nB-2i7pA:
undetectable		 3p5nB-2i7pA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		5 / 10 ALA A 335
ASP A 339
GLY A 302
ILE A 301
VAL A 318
 None
 0.99A 4dqhB-2i7pA:
undetectable		 4dqhB-2i7pA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		5 / 9 ALA A 335
ASP A 339
GLY A 302
ILE A 301
VAL A 318
 None
 1.02A 4q1wA-2i7pA:
undetectable		 4q1wA-2i7pA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		4 / 5 ARG A  64
THR A  61
ASP A  65
TYR A 356
 None
 1.37A 4qwpB-2i7pA:
undetectable		 4qwpB-2i7pA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		4 / 7 LEU A 235
GLY A 215
GLY A 214
ILE A 301
 None
 0.63A 4yjiA-2i7pA:
undetectable		 4yjiA-2i7pA:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		4 / 7 GLY A 193
SER A 195
ARG A 207
GLY A 210
 ACO  A1604 (-3.2A)
ACO  A1604 (-2.6A)
ACO  A1604 (-3.2A)
ACO  A1604 ( 3.9A)
 0.17A 5e26A-2i7pA:
37.9
5e26B-2i7pA:
37.8		 5e26A-2i7pA:
82.19
5e26B-2i7pA:
82.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		4 / 7 GLY A 193
SER A 195
ARG A 207
GLY A 210
 ACO  A1604 (-3.2A)
ACO  A1604 (-2.6A)
ACO  A1604 (-3.2A)
ACO  A1604 ( 3.9A)
 0.19A 5e26A-2i7pA:
37.9
5e26B-2i7pA:
37.8		 5e26A-2i7pA:
82.19
5e26B-2i7pA:
82.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		4 / 7 GLY A 193
SER A 195
ARG A 207
GLY A 210
 ACO  A1604 (-3.2A)
ACO  A1604 (-2.6A)
ACO  A1604 (-3.2A)
ACO  A1604 ( 3.9A)
 0.20A 5e26C-2i7pA:
38.0
5e26D-2i7pA:
38.1		 5e26C-2i7pA:
82.19
5e26D-2i7pA:
82.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		4 / 8 GLY A 193
SER A 195
ARG A 207
GLY A 210
 ACO  A1604 (-3.2A)
ACO  A1604 (-2.6A)
ACO  A1604 (-3.2A)
ACO  A1604 ( 3.9A)
 0.17A 5e26C-2i7pA:
38.0
5e26D-2i7pA:
38.1		 5e26C-2i7pA:
82.19
5e26D-2i7pA:
82.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		4 / 5 GLY A 193
SER A 195
ARG A 207
GLY A 210
 ACO  A1604 (-3.2A)
ACO  A1604 (-2.6A)
ACO  A1604 (-3.2A)
ACO  A1604 ( 3.9A)
 0.18A 5kprA-2i7pA:
38.4		 5kprA-2i7pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 2i7p PANTOTHENATE KINASE
3
(Homo
sapiens) 		5 / 12 VAL A 187
GLY A 145
ILE A 149
LEU A 197
VAL A 318
 None
 1.04A 6dh0B-2i7pA:
undetectable		 6dh0B-2i7pA:
12.19