SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i7t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 5 THR A  99
THR A  96
THR A 177
HIS A  76
 None
None
None
ZN  A 481 (-3.4A)
 1.28A 1d4fB-2i7tA:
undetectable		 1d4fB-2i7tA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 5 HIS A  76
HIS A 158
HIS A 396
HIS A 418
ASP A  75
 ZN  A 481 (-3.4A)
ZN  A 482 ( 3.3A)
SO4  A 491 (-4.0A)
ZN  A 481 ( 3.4A)
ZN  A 481 ( 2.6A)
 1.20A 1e9yB-2i7tA:
undetectable		 1e9yB-2i7tA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 6 HIS A  76
HIS A 158
HIS A 396
HIS A 418
ASP A  75
 ZN  A 481 (-3.4A)
ZN  A 482 ( 3.3A)
SO4  A 491 (-4.0A)
ZN  A 481 ( 3.4A)
ZN  A 481 ( 2.6A)
 1.18A 1fweC-2i7tA:
undetectable		 1fweC-2i7tA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 11 GLU A 248
HIS A 158
HIS A 396
ALA A 395
PHE A 393
 None
ZN  A 482 ( 3.3A)
SO4  A 491 (-4.0A)
None
None
 1.32A 1mjqA-2i7tA:
undetectable
1mjqB-2i7tA:
undetectable		 1mjqA-2i7tA:
12.28
1mjqB-2i7tA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 11 GLU A 248
HIS A 158
HIS A 396
ALA A 395
PHE A 393
 None
ZN  A 482 ( 3.3A)
SO4  A 491 (-4.0A)
None
None
 1.34A 1mjqI-2i7tA:
undetectable
1mjqJ-2i7tA:
undetectable		 1mjqI-2i7tA:
12.28
1mjqJ-2i7tA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 ASP A 179
HIS A 418
HIS A 396
 ZN  A 481 (-2.5A)
ZN  A 481 ( 3.4A)
SO4  A 491 (-4.0A)
 0.69A 1oe1A-2i7tA:
undetectable		 1oe1A-2i7tA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 GLU A 444
HIS A 446
HIS A 413
 None
 0.69A 1oe2A-2i7tA:
undetectable		 1oe2A-2i7tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 ASP A 179
HIS A 418
HIS A 396
 ZN  A 481 (-2.5A)
ZN  A 481 ( 3.4A)
SO4  A 491 (-4.0A)
 0.69A 1oe3A-2i7tA:
undetectable		 1oe3A-2i7tA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 ASN A 450
ILE A  59
MET A  38
 None
 0.85A 2h42C-2i7tA:
undetectable		 2h42C-2i7tA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 ARG A 218
ARG A 245
ARG A 215
 None
 1.18A 2jb7A-2i7tA:
undetectable
2jb7B-2i7tA:
undetectable
2jb7C-2i7tA:
undetectable		 2jb7A-2i7tA:
17.79
2jb7B-2i7tA:
17.79
2jb7C-2i7tA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 11 ASP A  75
HIS A  76
HIS A 158
ASP A 179
HIS A 418
 ZN  A 481 ( 2.6A)
ZN  A 481 (-3.4A)
ZN  A 482 ( 3.3A)
ZN  A 481 (-2.5A)
ZN  A 481 ( 3.4A)
 0.60A 2q0jB-2i7tA:
11.7		 2q0jB-2i7tA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 ASP A 179
HIS A 418
HIS A 396
 ZN  A 481 (-2.5A)
ZN  A 481 ( 3.4A)
SO4  A 491 (-4.0A)
 0.70A 2xxgA-2i7tA:
undetectable		 2xxgA-2i7tA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 ASP A 179
HIS A 418
HIS A 396
 ZN  A 481 (-2.5A)
ZN  A 481 ( 3.4A)
SO4  A 491 (-4.0A)
 0.70A 2xxgC-2i7tA:
undetectable		 2xxgC-2i7tA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 LEU A 128
TRP A  82
TYR A 110
 None
 0.90A 3aicB-2i7tA:
undetectable		 3aicB-2i7tA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 LEU A 128
TRP A  82
TYR A 110
 None
 0.86A 3aicE-2i7tA:
undetectable		 3aicE-2i7tA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 LEU A 128
TRP A  82
TYR A 110
 None
 0.90A 3aicG-2i7tA:
undetectable		 3aicG-2i7tA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 LEU A 128
TRP A  82
TYR A 110
 None
 0.86A 3aicH-2i7tA:
undetectable		 3aicH-2i7tA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 8 GLY A 208
GLU A 420
ASN A 422
ALA A 430
 None
 0.82A 3aodA-2i7tA:
undetectable		 3aodA-2i7tA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 8 LEU A 409
PHE A 405
THR A 177
ALA A 191
 None
 1.00A 3ax9A-2i7tA:
undetectable		 3ax9A-2i7tA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 9 ILE A 167
LEU A  68
ILE A  29
LYS A  90
GLY A  91
 None
 1.44A 3sj4X-2i7tA:
undetectable		 3sj4X-2i7tA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 8 ILE A  59
ASP A  60
ILE A  64
PHE A  89
 None
 0.81A 4ac9C-2i7tA:
3.2		 4ac9C-2i7tA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 10 HIS A  71
HIS A  73
ASP A  75
HIS A 158
HIS A 418
 ZN  A 482 (-3.5A)
ZN  A 482 ( 3.2A)
ZN  A 481 ( 2.6A)
ZN  A 482 ( 3.3A)
ZN  A 481 ( 3.4A)
 0.78A 4c1dB-2i7tA:
9.1		 4c1dB-2i7tA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 10 TYR A 357
HIS A  71
HIS A  73
ASP A  75
HIS A 418
 None
ZN  A 482 (-3.5A)
ZN  A 482 ( 3.2A)
ZN  A 481 ( 2.6A)
ZN  A 481 ( 3.4A)
 1.44A 4c1dB-2i7tA:
9.1		 4c1dB-2i7tA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		6 / 11 VAL A 359
HIS A  71
HIS A  73
ASP A  75
HIS A 158
HIS A 418
 None
ZN  A 482 (-3.5A)
ZN  A 482 ( 3.2A)
ZN  A 481 ( 2.6A)
ZN  A 482 ( 3.3A)
ZN  A 481 ( 3.4A)
 1.09A 4c1fA-2i7tA:
7.5
4c1fB-2i7tA:
9.7		 4c1fA-2i7tA:
19.83
4c1fB-2i7tA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 9 HIS A  71
HIS A  73
ASP A  75
HIS A 158
HIS A 418
 ZN  A 482 (-3.5A)
ZN  A 482 ( 3.2A)
ZN  A 481 ( 2.6A)
ZN  A 482 ( 3.3A)
ZN  A 481 ( 3.4A)
 0.80A 4c1hA-2i7tA:
10.5		 4c1hA-2i7tA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 8 HIS A  73
ASP A  75
HIS A 158
HIS A 418
 ZN  A 482 ( 3.2A)
ZN  A 481 ( 2.6A)
ZN  A 482 ( 3.3A)
ZN  A 481 ( 3.4A)
 0.78A 4exsB-2i7tA:
7.2		 4exsB-2i7tA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 6 GLY A 233
GLY A 234
ASN A 350
ILE A 266
 None
 0.87A 4fglD-2i7tA:
undetectable		 4fglD-2i7tA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 5 HIS A  76
HIS A 158
HIS A 396
HIS A 418
ASP A  75
 ZN  A 481 (-3.4A)
ZN  A 482 ( 3.3A)
SO4  A 491 (-4.0A)
ZN  A 481 ( 3.4A)
ZN  A 481 ( 2.6A)
 1.17A 4h9mA-2i7tA:
undetectable		 4h9mA-2i7tA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 7 ILE A 167
LEU A  68
LYS A  90
GLY A  91
 None
 1.03A 4hajA-2i7tA:
undetectable		 4hajA-2i7tA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 8 ILE A 167
LEU A  68
ILE A  29
LYS A  90
GLY A  91
 None
 1.45A 4hb6A-2i7tA:
undetectable		 4hb6A-2i7tA:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 8 SER A 337
SER A 334
LYS A 365
ALA A 364
 None
 0.91A 4ikjA-2i7tA:
undetectable
4ikjB-2i7tA:
undetectable		 4ikjA-2i7tA:
12.34
4ikjB-2i7tA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 11 GLY A 244
ARG A 245
ALA A 395
GLY A 356
ALA A 425
 None
 1.05A 4l6v1-2i7tA:
undetectable
4l6v6-2i7tA:
undetectable		 4l6v1-2i7tA:
20.69
4l6v6-2i7tA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 ILE A  56
GLY A  42
ILE A  69
MET A  38
LEU A 107
 None
 1.08A 4mwzA-2i7tA:
undetectable		 4mwzA-2i7tA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 6 ASP A 319
ARG A 235
GLY A 236
VAL A 230
 None
 1.04A 4oltA-2i7tA:
undetectable		 4oltA-2i7tA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 6 ASP A 319
ARG A 235
GLY A 236
VAL A 230
 None
 1.05A 4oltB-2i7tA:
undetectable		 4oltB-2i7tA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 5 HIS A 446
VAL A 445
GLU A 444
VAL A 454
 None
 1.35A 4p6vB-2i7tA:
undetectable
4p6vE-2i7tA:
undetectable		 4p6vB-2i7tA:
21.69
4p6vE-2i7tA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 6 HIS A  76
HIS A 158
HIS A 396
HIS A 418
ASP A  75
 ZN  A 481 (-3.4A)
ZN  A 482 ( 3.3A)
SO4  A 491 (-4.0A)
ZN  A 481 ( 3.4A)
ZN  A 481 ( 2.6A)
 1.17A 4ubpC-2i7tA:
undetectable		 4ubpC-2i7tA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 8 HIS A  73
ASP A  75
HIS A 158
HIS A 418
 ZN  A 482 ( 3.2A)
ZN  A 481 ( 2.6A)
ZN  A 482 ( 3.3A)
ZN  A 481 ( 3.4A)
 0.75A 5a5zA-2i7tA:
10.2		 5a5zA-2i7tA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		6 / 11 HIS A  71
HIS A  73
ASP A  75
HIS A  76
HIS A 158
HIS A 418
 ZN  A 482 (-3.5A)
ZN  A 482 ( 3.2A)
ZN  A 481 ( 2.6A)
ZN  A 481 (-3.4A)
ZN  A 482 ( 3.3A)
ZN  A 481 ( 3.4A)
 0.34A 5ayaA-2i7tA:
10.8		 5ayaA-2i7tA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 5 PRO A  54
HIS A  71
LEU A 128
PHE A 241
 None
ZN  A 482 (-3.5A)
None
None
 1.49A 5igjA-2i7tA:
undetectable		 5igjA-2i7tA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 TYR A 357
TYR A 176
SER A  26
 None
 0.95A 5iktB-2i7tA:
undetectable		 5iktB-2i7tA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 LYS A  36
LEU A 174
ILE A  28
 None
 0.60A 5kc0A-2i7tA:
undetectable		 5kc0A-2i7tA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 LYS A  36
LEU A 174
ILE A  28
 None
 0.66A 5kc4A-2i7tA:
undetectable		 5kc4A-2i7tA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 9 SER A  70
PRO A  81
TYR A 123
LEU A 107
SER A  26
 None
 1.43A 5l1fB-2i7tA:
0.0		 5l1fB-2i7tA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 10 HIS A 396
HIS A 418
HIS A  71
HIS A  73
LEU A  74
 SO4  A 491 (-4.0A)
ZN  A 481 ( 3.4A)
ZN  A 482 (-3.5A)
ZN  A 482 ( 3.2A)
None
 1.32A 5m8nA-2i7tA:
undetectable		 5m8nA-2i7tA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 8 HIS A  73
HIS A 396
GLY A 157
VAL A 159
 ZN  A 482 ( 3.2A)
SO4  A 491 (-4.0A)
None
None
 0.99A 5m8rC-2i7tA:
undetectable		 5m8rC-2i7tA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 8 ASP A 179
HIS A  76
HIS A 418
HIS A 158
 ZN  A 481 (-2.5A)
ZN  A 481 (-3.4A)
ZN  A 481 ( 3.4A)
ZN  A 482 ( 3.3A)
 0.88A 5nekD-2i7tA:
undetectable		 5nekD-2i7tA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		7 / 10 HIS A  71
HIS A  73
HIS A  76
HIS A 158
ASP A 179
TYR A 207
HIS A 396
 ZN  A 482 (-3.5A)
ZN  A 482 ( 3.2A)
ZN  A 481 (-3.4A)
ZN  A 482 ( 3.3A)
ZN  A 481 (-2.5A)
None
SO4  A 491 (-4.0A)
 0.61A 5nzwA-2i7tA:
16.4		 5nzwA-2i7tA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 10 HIS A  76
HIS A 418
HIS A  71
ASP A 179
HIS A 158
 ZN  A 481 (-3.4A)
ZN  A 481 ( 3.4A)
ZN  A 482 (-3.5A)
ZN  A 481 (-2.5A)
ZN  A 482 ( 3.3A)
 0.96A 5nzwA-2i7tA:
16.4		 5nzwA-2i7tA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 10 HIS A 158
HIS A  71
HIS A 396
ASP A 179
HIS A 418
 ZN  A 482 ( 3.3A)
ZN  A 482 (-3.5A)
SO4  A 491 (-4.0A)
ZN  A 481 (-2.5A)
ZN  A 481 ( 3.4A)
 1.02A 5nzwA-2i7tA:
16.4		 5nzwA-2i7tA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 THR A 206
GLU A 204
HIS A 158
 None
None
ZN  A 482 ( 3.3A)
 0.84A 5xioA-2i7tA:
undetectable		 5xioA-2i7tA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 THR A 206
GLU A 204
HIS A 158
 None
None
ZN  A 482 ( 3.3A)
 0.84A 5xiqB-2i7tA:
undetectable		 5xiqB-2i7tA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 THR A 206
GLU A 204
HIS A 158
 None
None
ZN  A 482 ( 3.3A)
 0.87A 5xiqD-2i7tA:
undetectable		 5xiqD-2i7tA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 8 HIS A  73
ASP A  75
HIS A 158
HIS A 418
 ZN  A 482 ( 3.2A)
ZN  A 481 ( 2.6A)
ZN  A 482 ( 3.3A)
ZN  A 481 ( 3.4A)
 0.83A 5zj8A-2i7tA:
10.5		 5zj8A-2i7tA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 8 MET A 331
HIS A  73
ASP A  75
HIS A 158
 None
ZN  A 482 ( 3.2A)
ZN  A 481 ( 2.6A)
ZN  A 482 ( 3.3A)
 1.03A 5zj8A-2i7tA:
10.5		 5zj8A-2i7tA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 ARG A 218
ILE A 391
SER A 392
 None
 0.81A 5zw2A-2i7tA:
undetectable		 5zw2A-2i7tA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 4 PRO A 371
MET A 332
GLY A 330
VAL A 352
 None
 1.43A 6ak3A-2i7tA:
undetectable		 6ak3A-2i7tA:
10.46