SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i7x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 383
VAL A 655
LEU A 366
ILE A 353
ILE A 349
 None
 0.99A 1epbA-2i7xA:
undetectable		 1epbA-2i7xA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 300
THR A 289
ALA A 293
LEU A 297
 None
 1.12A 1etb2-2i7xA:
undetectable		 1etb2-2i7xA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 149
ALA A 153
VAL A  25
TYR A  88
GLN A  86
 None
 1.14A 1kt4A-2i7xA:
undetectable		 1kt4A-2i7xA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 149
ALA A 153
VAL A  25
TYR A  88
GLN A  86
 None
 1.15A 1kt6A-2i7xA:
undetectable		 1kt6A-2i7xA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 149
ALA A 153
VAL A  25
TYR A  88
GLN A  86
 None
 1.16A 1kt7A-2i7xA:
undetectable		 1kt7A-2i7xA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 149
ALA A 153
VAL A  25
TYR A  88
GLN A  86
 None
 1.04A 1rlbF-2i7xA:
undetectable		 1rlbF-2i7xA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 290
GLY A 287
ILE A 323
PHE A 341
 None
 0.95A 1xf1A-2i7xA:
undetectable		 1xf1A-2i7xA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		3 / 3 SER A 283
ASP A 249
CYH A 159
 None
 1.04A 2br4E-2i7xA:
1.7		 2br4E-2i7xA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 216
CYH A 373
THR A  63
ILE A  64
 None
 0.98A 3bpxA-2i7xA:
undetectable
3bpxB-2i7xA:
undetectable		 3bpxA-2i7xA:
12.25
3bpxB-2i7xA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 410
ILE A 412
ARG A 642
SER A 107
 None
 1.38A 3ckzA-2i7xA:
undetectable		 3ckzA-2i7xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		4 / 7 THR A 259
VAL A 261
ILE A 319
SER A 315
 None
 0.84A 3deuA-2i7xA:
undetectable		 3deuA-2i7xA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		5 / 12 THR A 259
ASP A 256
ASN A 186
LEU A 264
THR A 314
 None
 1.07A 3eeyC-2i7xA:
2.1		 3eeyC-2i7xA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 187
PRO A  92
ASN A  95
GLY A 252
 None
 0.87A 3em0B-2i7xA:
undetectable		 3em0B-2i7xA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		5 / 12 CYH A 166
THR A 212
LEU A 676
ILE A 193
TYR A   3
 None
 1.26A 3gwxB-2i7xA:
undetectable		 3gwxB-2i7xA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  59
GLY A  68
GLY A  32
SER A  36
ASP A 249
 None
 1.07A 3i5uB-2i7xA:
undetectable		 3i5uB-2i7xA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 149
LEU A 134
TYR A  88
ILE A 167
 None
 0.94A 3ln1A-2i7xA:
undetectable		 3ln1A-2i7xA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 199
PRO A 200
LEU A 201
 None
 0.88A 3tpxE-2i7xA:
undetectable		 3tpxE-2i7xA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 162
VAL A  93
PRO A 160
GLY A 252
 None
 0.83A 4dxuA-2i7xA:
undetectable		 4dxuA-2i7xA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		6 / 11 PHE A 128
ALA A  69
LEU A  73
VAL A 110
GLU A 125
LEU A 119
 None
 1.34A 4iaaA-2i7xA:
undetectable		 4iaaA-2i7xA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 344
ASP A 103
GLU A 372
GLY A  68
ILE A 111
 None
 1.29A 4xe5A-2i7xA:
2.6		 4xe5A-2i7xA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 282
ASP A 103
ILE A 339
 None
 0.59A 4xi3D-2i7xA:
undetectable		 4xi3D-2i7xA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 164
CYH A 166
SER A 168
ILE A 210
 None
 0.81A 4xtaB-2i7xA:
undetectable		 4xtaB-2i7xA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		4 / 4 SER A 645
GLU A 351
SER A 107
ASP A 410
 None
 1.46A 4xucA-2i7xA:
2.4		 4xucA-2i7xA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		4 / 6 SER A 343
GLU A 344
GLY A 112
GLY A 109
 None
 0.90A 5cdnR-2i7xA:
undetectable
5cdnS-2i7xA:
undetectable		 5cdnR-2i7xA:
21.20
5cdnS-2i7xA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 317
GLY A 320
ILE A 319
ALA A 293
LEU A 300
 None
 0.92A 5e72A-2i7xA:
undetectable		 5e72A-2i7xA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 317
ILE A 323
ALA A 293
PRO A 316
LEU A 300
 None
 1.06A 5e72A-2i7xA:
undetectable		 5e72A-2i7xA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 410
VAL A 345
ILE A 353
ILE A 409
ILE A 354
 None
 1.30A 5hw8B-2i7xA:
undetectable		 5hw8B-2i7xA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 111
LEU A 119
TRP A  33
GLY A 109
TYR A  40
 None
 1.01A 5nnaA-2i7xA:
undetectable		 5nnaA-2i7xA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 111
LEU A 119
TRP A  33
GLY A 109
TYR A  40
 None
 1.03A 5nnaD-2i7xA:
undetectable		 5nnaD-2i7xA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		4 / 6 SER A 343
ALA A 347
ALA A 106
SER A 107
 None
 0.94A 6bocA-2i7xA:
undetectable
6bocB-2i7xA:
undetectable
6bocC-2i7xA:
undetectable
6bocD-2i7xA:
undetectable		 6bocA-2i7xA:
3.47
6bocB-2i7xA:
3.47
6bocC-2i7xA:
3.47
6bocD-2i7xA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 175
LEU A 676
TYR A 154
LEU A 194
 None
 1.02A 6f6sA-2i7xA:
undetectable
6f6sB-2i7xA:
undetectable		 6f6sA-2i7xA:
9.41
6f6sB-2i7xA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 297
LEU A 304
SER A 315
THR A 259
 None
 0.91A 6f88B-2i7xA:
undetectable		 6f88B-2i7xA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2i7x PROTEIN CFT2
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 277
ILE A 319
MET A 250
GLY A 252
 None
 0.84A 6hd6B-2i7xA:
undetectable		 6hd6B-2i7xA:
8.64