SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i82'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXW_D_017D200_1 (HIV-1 PROTEASE)	2i82	RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE A (Escherichia coli)	5 / 10	ALA A 217 ASP A 218 GLY A 69 VAL A 70 VAL A 153	None	1.02A	3oxwC-2i82A: undetectable	3oxwC-2i82A: 17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QL6_A_NIMA614_1 (LACTOPEROXIDASE)	2i82	RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE A (Escherichia coli)	4 / 7	GLN A 125 HIS A 162 ARG A 165 PRO A 156	A E1211 ( 3.7A) G E1210 ( 3.8A) None None	1.42A	3ql6A-2i82A: undetectable	3ql6A-2i82A: 17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OF1_A_SALA301_1 (SPORE COAT-ASSOCIATED PROTEIN N)	2i82	RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE A (Escherichia coli)	4 / 5	ALA A 74 VAL A 72 LYS A 84 ILE A 202	None None C E1216 ( 2.7A) None	0.95A	5of1A-2i82A: undetectable	5of1A-2i82A: 17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6APH_A_ADNA501_2 (ADENOSYLHOMOCYSTEINA SE)	2i82	RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE A (Escherichia coli)	4 / 5	GLN A 136 THR A 137 HIS A 162 LEU A 115	None None G E1210 ( 3.8A) None	1.43A	6aphA-2i82A: undetectable	6aphA-2i82A: 18.28

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3OXW_D_017D200_1","HIV-1 PROTEASE;HIV-1 PROTEASE","2i82","RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE A","Escherichia coli",5,"ALA A 217;ASP A 218;GLY A  69;VAL A  70;VAL A 153","None","1.02A","3oxwC-2i82A:undetectable","3oxwC-2i82A:17.06"],["3QL6_A_NIMA614_1","LACTOPEROXIDASE","2i82","RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE A","Escherichia coli",4,"GLN A 125;HIS A 162;ARG A 165;PRO A 156","  A E1211 ( 3.7A);  G E1210 ( 3.8A);None;None","1.42A","3ql6A-2i82A:undetectable","3ql6A-2i82A:17.36"],["5OF1_A_SALA301_1","SPORE COAT-ASSOCIATED PROTEIN N","2i82","RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE A","Escherichia coli",4,"ALA A  74;VAL A  72;LYS A  84;ILE A 202","None;None;  C E1216 ( 2.7A);None","0.95A","5of1A-2i82A:undetectable","5of1A-2i82A:17.67"],["6APH_A_ADNA501_2","ADENOSYLHOMOCYSTEINASE","2i82","RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE A","Escherichia coli",4,"GLN A 136;THR A 137;HIS A 162;LEU A 115","None;None;  G E1210 ( 3.8A);None","1.43A","6aphA-2i82A:undetectable","6aphA-2i82A:18.28"]]