SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i8b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3S_E_9PLE1_1 (CYTOCHROME P450 2A13)	2i8b	MINOR NUCLEOPROTEIN VP30 (Zaire ebolavirus)	4 / 8	PHE A 242 ALA A 155 PHE A 181 ASN A 244	None	1.00A	3t3sE-2i8bA: undetectable	3t3sE-2i8bA: 15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3S_F_9PLF1_1 (CYTOCHROME P450 2A13)	2i8b	MINOR NUCLEOPROTEIN VP30 (Zaire ebolavirus)	4 / 8	PHE A 242 ALA A 155 PHE A 181 ASN A 244	None	0.89A	3t3sF-2i8bA: undetectable	3t3sF-2i8bA: 15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DAJ_B_0HKB2000_2 (MUSCARINIC ACETYLCHOLINE RECEPTOR M3, LYSOZYME)	2i8b	MINOR NUCLEOPROTEIN VP30 (Zaire ebolavirus)	3 / 3	ASN A 244 LEU A 199 PHE A 242	None	0.67A	4dajB-2i8bA: undetectable	4dajB-2i8bA: 15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YV5_B_SVRB207_2 (BASIC PHOSPHOLIPASE A2 HOMOLOG 2)	2i8b	MINOR NUCLEOPROTEIN VP30 (Zaire ebolavirus)	4 / 7	LYS A 180 TYR A 211 LEU A 214 PHE A 222	None	1.21A	4yv5B-2i8bA: undetectable	4yv5B-2i8bA: 18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DEB_B_MTXB302_1 (BIFUNCTIONAL PROTEIN FOLD)	2i8b	MINOR NUCLEOPROTEIN VP30 (Zaire ebolavirus)	5 / 12	LEU A 249 GLN A 185 LEU A 186 PHE A 242 VAL A 176	None	1.28A	6debB-2i8bA: undetectable	6debB-2i8bA: 20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FOS_A_PQNA2001_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1)	2i8b	MINOR NUCLEOPROTEIN VP30 (Zaire ebolavirus)	4 / 6	TRP A 230 GLY A 220 ALA A 225 LEU A 226	None	0.76A	6fosA-2i8bA: undetectable	6fosA-2i8bA: 18.31

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3T3S_E_9PLE1_1","CYTOCHROME P450 2A13","2i8b","MINOR NUCLEOPROTEIN VP30","Zaire ebolavirus",4,"PHE A 242;ALA A 155;PHE A 181;ASN A 244","None","1.00A","3t3sE-2i8bA:undetectable","3t3sE-2i8bA:15.02"],["3T3S_F_9PLF1_1","CYTOCHROME P450 2A13","2i8b","MINOR NUCLEOPROTEIN VP30","Zaire ebolavirus",4,"PHE A 242;ALA A 155;PHE A 181;ASN A 244","None","0.89A","3t3sF-2i8bA:undetectable","3t3sF-2i8bA:15.02"],["4DAJ_B_0HKB2000_2","MUSCARINIC ACETYLCHOLINE RECEPTOR M3, LYSOZYME","2i8b","MINOR NUCLEOPROTEIN VP30","Zaire ebolavirus",3,"ASN A 244;LEU A 199;PHE A 242","None","0.67A","4dajB-2i8bA:undetectable","4dajB-2i8bA:15.53"],["4YV5_B_SVRB207_2","BASIC PHOSPHOLIPASE A2 HOMOLOG 2","2i8b","MINOR NUCLEOPROTEIN VP30","Zaire ebolavirus",4,"LYS A 180;TYR A 211;LEU A 214;PHE A 222","None","1.21A","4yv5B-2i8bA:undetectable","4yv5B-2i8bA:18.02"],["6DEB_B_MTXB302_1","BIFUNCTIONAL PROTEIN FOLD","2i8b","MINOR NUCLEOPROTEIN VP30","Zaire ebolavirus",5,"LEU A 249;GLN A 185;LEU A 186;PHE A 242;VAL A 176","None","1.28A","6debB-2i8bA:undetectable","6debB-2i8bA:20.75"],["6FOS_A_PQNA2001_1","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1","2i8b","MINOR NUCLEOPROTEIN VP30","Zaire ebolavirus",4,"TRP A 230;GLY A 220;ALA A 225;LEU A 226","None","0.76A","6fosA-2i8bA:undetectable","6fosA-2i8bA:18.31"]]