SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i8l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2i8l HYDROGENASE 3
MATURATION PROTEASE
(Escherichia
coli) 		4 / 7 ALA A  49
GLU A  52
LEU A  53
VAL A  35
 None
 0.81A 1hk2A-2i8lA:
undetectable		 1hk2A-2i8lA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 2i8l HYDROGENASE 3
MATURATION PROTEASE
(Escherichia
coli) 		6 / 12 GLY A  19
ALA A  18
ASP A  16
ILE A  60
ILE A  73
ILE A 113
 None
 1.21A 1hshA-2i8lA:
undetectable		 1hshA-2i8lA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 2i8l HYDROGENASE 3
MATURATION PROTEASE
(Escherichia
coli) 		5 / 11 LEU A   5
VAL A   8
GLY A  19
TRP A 142
LEU A 139
 None
 1.32A 1jkhA-2i8lA:
undetectable
1jkhB-2i8lA:
undetectable		 1jkhA-2i8lA:
14.34
1jkhB-2i8lA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2i8l HYDROGENASE 3
MATURATION PROTEASE
(Escherichia
coli) 		5 / 9 LEU A   5
VAL A   8
GLY A  19
TRP A 142
LEU A 139
 None
 1.36A 1lwfA-2i8lA:
undetectable		 1lwfA-2i8lA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 2i8l HYDROGENASE 3
MATURATION PROTEASE
(Escherichia
coli) 		5 / 9 ASP A   3
LEU A 139
VAL A  61
ILE A  60
ILE A 105
 None
 1.33A 1q6iA-2i8lA:
undetectable		 1q6iA-2i8lA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2i8l HYDROGENASE 3
MATURATION PROTEASE
(Escherichia
coli) 		5 / 12 LEU A  22
GLY A  19
GLY A   9
SER A  41
ILE A 113
 None
 0.96A 3cjtO-2i8lA:
2.8		 3cjtO-2i8lA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2i8l HYDROGENASE 3
MATURATION PROTEASE
(Escherichia
coli) 		5 / 12 ALA A  49
ILE A  60
LEU A  58
GLY A  39
VAL A  36
 None
 0.95A 3rukB-2i8lA:
undetectable		 3rukB-2i8lA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 2i8l HYDROGENASE 3
MATURATION PROTEASE
(Escherichia
coli) 		6 / 12 GLY A  19
ALA A  18
ASP A  16
ILE A  60
ILE A  73
ILE A 113
 None
 1.26A 3s54B-2i8lA:
undetectable		 3s54B-2i8lA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2i8l HYDROGENASE 3
MATURATION PROTEASE
(Escherichia
coli) 		3 / 3 VAL A  61
ALA A  63
PHE A 110
 None
 0.93A 4olbA-2i8lA:
undetectable		 4olbA-2i8lA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2i8l HYDROGENASE 3
MATURATION PROTEASE
(Escherichia
coli) 		3 / 3 VAL A  61
ALA A  63
PHE A 110
 None
 0.91A 4w5nA-2i8lA:
undetectable		 4w5nA-2i8lA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 2i8l HYDROGENASE 3
MATURATION PROTEASE
(Escherichia
coli) 		4 / 8 ILE A 105
VAL A 108
GLN A 100
GLU A 103
 None
 1.13A 5dqyA-2i8lA:
undetectable		 5dqyA-2i8lA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2i8l HYDROGENASE 3
MATURATION PROTEASE
(Escherichia
coli) 		3 / 3 VAL A  61
ALA A  63
PHE A 110
 None
 0.91A 5js1A-2i8lA:
3.7		 5js1A-2i8lA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2i8l HYDROGENASE 3
MATURATION PROTEASE
(Escherichia
coli) 		5 / 10 ALA A  63
PHE A 148
ILE A  75
VAL A 135
ALA A  18
 None
 1.22A 5nukA-2i8lA:
undetectable		 5nukA-2i8lA:
18.87