SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i9e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		5 / 10 GLY A 208
VAL A 211
ALA A 180
ASN A 215
ILE A 225
 None
 1.06A 1likA-2i9eA:
undetectable		 1likA-2i9eA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		4 / 7 PHE A 143
ALA A 186
ILE A 126
ILE A 205
 None
 0.92A 1oniD-2i9eA:
undetectable
1oniF-2i9eA:
undetectable		 1oniD-2i9eA:
23.67
1oniF-2i9eA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		3 / 3 ARG A 144
VAL A 183
GLY A 208
 None
 0.61A 2avvE-2i9eA:
undetectable		 2avvE-2i9eA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		4 / 6 ARG A 246
GLU A 218
PRO A 177
ALA A 180
 None
 1.17A 2ejfB-2i9eA:
undetectable		 2ejfB-2i9eA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		4 / 7 ARG A 246
GLU A 218
PRO A 177
ALA A 180
 None
 1.15A 2ejgA-2i9eA:
undetectable		 2ejgA-2i9eA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		5 / 11 LEU A  92
GLY A  93
ILE A 108
ILE A 149
VAL A 122
 None
 1.03A 2kawA-2i9eA:
undetectable		 2kawA-2i9eA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		5 / 12 ILE A 242
PHE A 228
ALA A 220
ASN A 244
THR A  36
 None
 0.90A 2rlcA-2i9eA:
undetectable		 2rlcA-2i9eA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		4 / 7 VAL A   7
ILE A 242
ALA A 245
GLY A 227
 None
 0.74A 2xrzB-2i9eA:
undetectable		 2xrzB-2i9eA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		4 / 7 ILE A 225
LEU A 219
HIS A 184
SER A  95
 None
 0.88A 3r9vA-2i9eA:
undetectable
3r9vB-2i9eA:
undetectable		 3r9vA-2i9eA:
21.68
3r9vB-2i9eA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		4 / 6 ILE A  24
LEU A  27
PHE A 239
GLY A   8
 None
 0.95A 3sj1X-2i9eA:
undetectable		 3sj1X-2i9eA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		5 / 8 GLY A 208
GLY A 209
GLY A 227
ILE A 242
VAL A   7
 None
 1.20A 3v1nA-2i9eA:
undetectable		 3v1nA-2i9eA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		4 / 8 ASP A 241
ILE A 242
PHE A 239
GLY A   9
 None
 0.77A 4ac9C-2i9eA:
3.5		 4ac9C-2i9eA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		4 / 7 ILE A  24
LEU A  27
PHE A 239
GLY A   8
 None
 0.98A 4hbfA-2i9eA:
undetectable		 4hbfA-2i9eA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		4 / 7 ILE A  24
LEU A  27
PHE A 239
GLY A   8
 None
 1.00A 4hc3A-2i9eA:
undetectable		 4hc3A-2i9eA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		5 / 12 ILE A 123
VAL A 142
ILE A 126
GLU A 128
GLU A 132
 None
 1.31A 4i41A-2i9eA:
undetectable		 4i41A-2i9eA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		4 / 8 SER A 234
GLY A   9
TYR A  46
ALA A  44
 None
 0.72A 5albL-2i9eA:
undetectable		 5albL-2i9eA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		4 / 6 ILE A 149
ALA A 115
VAL A 122
HIS A 114
 None
 0.88A 5eclD-2i9eA:
undetectable		 5eclD-2i9eA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		4 / 6 ILE A  20
VAL A  40
VAL A  50
TRP A  11
 None
 0.88A 5jwaH-2i9eA:
undetectable		 5jwaH-2i9eA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		4 / 6 ILE A  24
VAL A  42
VAL A  50
TRP A  11
 None
 0.90A 5jwaH-2i9eA:
undetectable		 5jwaH-2i9eA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		4 / 8 GLN A 206
ALA A 220
GLN A 222
HIS A 184
 None
 1.12A 5km8A-2i9eA:
undetectable
5km8B-2i9eA:
undetectable		 5km8A-2i9eA:
21.88
5km8B-2i9eA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		5 / 11 THR A  36
PHE A   5
ALA A 220
THR A 212
ALA A 233
 None
 1.18A 6efnA-2i9eA:
3.8		 6efnA-2i9eA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		4 / 8 ASP A 105
ARG A 144
ARG A  98
ASN A 194
 None
 1.10A 6hisA-2i9eA:
undetectable
6hisB-2i9eA:
undetectable		 6hisA-2i9eA:
16.21
6hisB-2i9eA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		4 / 8 ASP A 105
ARG A 144
ARG A  98
ASN A 194
 None
 1.10A 6hisB-2i9eA:
undetectable
6hisC-2i9eA:
undetectable		 6hisB-2i9eA:
16.21
6hisC-2i9eA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		4 / 8 ASP A 105
ARG A 144
ARG A  98
ASN A 194
 None
 1.10A 6hisC-2i9eA:
undetectable
6hisD-2i9eA:
undetectable		 6hisC-2i9eA:
16.21
6hisD-2i9eA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		4 / 8 ASP A 105
ARG A 144
ARG A  98
ASN A 194
 None
 1.10A 6hisD-2i9eA:
undetectable
6hisE-2i9eA:
undetectable		 6hisD-2i9eA:
16.21
6hisE-2i9eA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2i9e TRIOSEPHOSPHATE
ISOMERASE
(Tenebrio
molitor) 		4 / 8 ASN A 194
ASP A 105
ARG A 144
ARG A  98
 None
 1.11A 6hisA-2i9eA:
undetectable
6hisE-2i9eA:
undetectable		 6hisA-2i9eA:
16.21
6hisE-2i9eA:
16.21