SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i9k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 8 GLN A 301
PHE A 302
TYR A 289
GLY A  22
GLY A  23
 None
None
None
None
SAH  A 328 (-3.6A)
 1.49A 1ekjE-2i9kA:
undetectable
1ekjF-2i9kA:
undetectable		 1ekjE-2i9kA:
21.36
1ekjF-2i9kA:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		8 / 8 PHE A  18
GLU A  40
TRP A  41
ASP A  60
ILE A  61
THR A  62
PRO A  80
LEU A 100
 SAH  A 328 (-4.9A)
SAH  A 328 (-2.8A)
SAH  A 328 (-3.4A)
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 ( 4.3A)
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
 0.52A 1hmyA-2i9kA:
43.3		 1hmyA-2i9kA:
99.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 11 LEU A 197
GLU A 278
ALA A 298
TYR A 299
ARG A 272
 None
 1.40A 1l5rA-2i9kA:
4.4		 1l5rA-2i9kA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 GLY A  20
ASP A  42
ASP A  60
ILE A  61
PRO A  80
 SAH  A 328 (-3.3A)
None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-4.0A)
 0.45A 1qaoA-2i9kA:
7.7		 1qaoA-2i9kA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		6 / 12 ALA A  19
GLY A  22
GLY A  23
ILE A  61
ASP A 103
PRO A  80
 None
None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
None
SAH  A 328 (-4.0A)
 1.21A 1sqfA-2i9kA:
9.0		 1sqfA-2i9kA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 GLY A  22
GLY A  23
ASP A  42
ASP A  60
PRO A  80
 None
SAH  A 328 (-3.6A)
None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.0A)
 0.59A 1sqfA-2i9kA:
9.0		 1sqfA-2i9kA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 11 GLU A  40
ASP A  42
ALA A  45
ASP A  60
PRO A  80
 SAH  A 328 (-2.8A)
None
SAH  A 328 ( 4.8A)
SAH  A 328 (-3.6A)
SAH  A 328 (-4.0A)
 0.64A 2admA-2i9kA:
4.1		 2admA-2i9kA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 ILE A 169
LEU A   9
PHE A 117
SER A  30
ILE A 314
 None
 1.13A 2bl9A-2i9kA:
undetectable		 2bl9A-2i9kA:
21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		10 / 12 PHE A  18
GLY A  20
ASN A  39
TRP A  41
ASP A  42
ASP A  60
ILE A  61
PRO A  80
LEU A 100
TYR A 289
 SAH  A 328 (-4.9A)
SAH  A 328 (-3.3A)
SAH  A 328 (-4.3A)
SAH  A 328 (-3.4A)
None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
None
 1.05A 2hmyB-2i9kA:
43.7		 2hmyB-2i9kA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		6 / 12 PHE A  18
GLY A  20
GLY A  22
PRO A  80
LEU A 100
TYR A 285
 SAH  A 328 (-4.9A)
SAH  A 328 (-3.3A)
None
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
None
 1.10A 2hmyB-2i9kA:
43.7		 2hmyB-2i9kA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		6 / 12 PHE A  18
GLY A  20
GLY A  22
PRO A  80
LEU A 100
TYR A 289
 SAH  A 328 (-4.9A)
SAH  A 328 (-3.3A)
None
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
None
 1.23A 2hmyB-2i9kA:
43.7		 2hmyB-2i9kA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		12 / 12 PHE A  18
GLY A  20
GLY A  23
ASN A  39
TRP A  41
ASP A  42
ASP A  60
ILE A  61
PRO A  80
LEU A 100
TYR A 285
VAL A 306
 SAH  A 328 (-4.9A)
SAH  A 328 (-3.3A)
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-3.4A)
None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
None
SAH  A 328 (-4.4A)
 0.52A 2hmyB-2i9kA:
43.7		 2hmyB-2i9kA:
99.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 LEU A 133
ALA A 149
THR A 139
MET A 140
PHE A  93
 None
 1.37A 2qo4A-2i9kA:
undetectable		 2qo4A-2i9kA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		4 / 8 PHE A  24
GLY A  22
ILE A 308
ALA A  27
 SAH  A 328 (-4.8A)
None
None
None
 0.89A 3aodA-2i9kA:
undetectable		 3aodA-2i9kA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		4 / 8 SER A 146
GLY A 319
ILE A  74
ALA A  33
 None
 0.82A 3aodA-2i9kA:
undetectable		 3aodA-2i9kA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		6 / 12 PHE A  18
GLY A  20
GLY A  23
PRO A  80
LEU A 100
VAL A 306
 SAH  A 328 (-4.9A)
SAH  A 328 (-3.3A)
SAH  A 328 (-3.6A)
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
SAH  A 328 (-4.4A)
 0.74A 3av6A-2i9kA:
18.4		 3av6A-2i9kA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		6 / 12 PHE A  18
GLY A  20
PRO A  80
LEU A 100
ASN A 304
VAL A 306
 SAH  A 328 (-4.9A)
SAH  A 328 (-3.3A)
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
SAH  A 328 (-3.7A)
SAH  A 328 (-4.4A)
 0.82A 3av6A-2i9kA:
18.4		 3av6A-2i9kA:
12.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		6 / 12 LEU A  21
GLY A  23
ASP A 103
ILE A 104
TYR A 285
ASN A 304
 SAH  A 328 (-4.1A)
SAH  A 328 (-3.6A)
None
None
None
SAH  A 328 (-3.7A)
 1.40A 3eeoA-2i9kA:
54.1		 3eeoA-2i9kA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		9 / 12 PHE A  18
LEU A  21
ASN A  39
TRP A  41
ASP A  42
ASP A  60
ILE A  61
LEU A 100
TYR A 289
 SAH  A 328 (-4.9A)
SAH  A 328 (-4.1A)
SAH  A 328 (-4.3A)
SAH  A 328 (-3.4A)
None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 ( 4.9A)
None
 1.25A 3eeoA-2i9kA:
54.1		 3eeoA-2i9kA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		7 / 12 PHE A  18
LEU A  21
GLY A  22
PRO A  80
LEU A 100
TYR A 285
ASN A 304
 SAH  A 328 (-4.9A)
SAH  A 328 (-4.1A)
None
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
None
SAH  A 328 (-3.7A)
 1.08A 3eeoA-2i9kA:
54.1		 3eeoA-2i9kA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		12 / 12 PHE A  18
LEU A  21
GLY A  23
ASN A  39
TRP A  41
ASP A  42
ASP A  60
ILE A  61
PRO A  80
LEU A 100
TYR A 285
ASN A 304
 SAH  A 328 (-4.9A)
SAH  A 328 (-4.1A)
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-3.4A)
None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
None
SAH  A 328 (-3.7A)
 0.47A 3eeoA-2i9kA:
54.1		 3eeoA-2i9kA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		3 / 3 GLU A  40
SER A 305
VAL A 306
 SAH  A 328 (-2.8A)
SAH  A 328 (-2.7A)
SAH  A 328 (-4.4A)
 0.46A 3eeoA-2i9kA:
54.1		 3eeoA-2i9kA:
99.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 GLY A  20
GLU A  40
ASP A  42
ASP A  60
PRO A  80
 SAH  A 328 (-3.3A)
SAH  A 328 (-2.8A)
None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.0A)
 0.82A 3fuuA-2i9kA:
8.2		 3fuuA-2i9kA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		3 / 3 GLY A 284
PRO A 160
LEU A 195
 None
 0.61A 3hcpB-2i9kA:
2.8		 3hcpB-2i9kA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 GLY A  22
GLY A  23
ASP A  42
PRO A  80
LEU A 100
 None
SAH  A 328 (-3.6A)
None
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
 0.85A 3m6vA-2i9kA:
8.0		 3m6vA-2i9kA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 GLY A  22
GLY A  23
ASP A  42
PRO A  80
LEU A 100
 None
SAH  A 328 (-3.6A)
None
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
 0.85A 3m6vB-2i9kA:
8.0		 3m6vB-2i9kA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 GLY A  22
GLY A  23
ASP A  42
PRO A  80
LEU A 100
 None
SAH  A 328 (-3.6A)
None
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
 0.85A 3m6wA-2i9kA:
8.4		 3m6wA-2i9kA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 11 VAL A 310
PHE A  14
GLY A  23
GLY A  22
TYR A  49
 None
None
SAH  A 328 (-3.6A)
None
None
 1.41A 3owxA-2i9kA:
undetectable
3owxB-2i9kA:
3.5		 3owxA-2i9kA:
21.53
3owxB-2i9kA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		4 / 6 PHE A  79
PHE A  18
ALA A 105
THR A 139
 None
SAH  A 328 (-4.9A)
None
None
 0.95A 3t3sB-2i9kA:
undetectable		 3t3sB-2i9kA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		4 / 8 PHE A  79
PHE A  18
ALA A 105
THR A 139
 None
SAH  A 328 (-4.9A)
None
None
 1.00A 3t3sE-2i9kA:
undetectable		 3t3sE-2i9kA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 11 GLY A  20
ASP A  42
ASP A  60
PRO A  80
LEU A 100
 SAH  A 328 (-3.3A)
None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
 0.94A 3v8vB-2i9kA:
9.9		 3v8vB-2i9kA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 TYR A 285
GLY A 284
ALA A 248
PHE A 302
LEU A 274
 None
 1.18A 3vywA-2i9kA:
6.9		 3vywA-2i9kA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 TYR A 285
GLY A 284
ALA A 248
PHE A 302
LEU A 274
 None
 1.20A 3vywB-2i9kA:
5.9		 3vywB-2i9kA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 TYR A 285
GLY A 284
ALA A 248
PHE A 302
LEU A 274
 None
 1.17A 3vywD-2i9kA:
6.9		 3vywD-2i9kA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 GLY A  22
GLY A  23
ASN A  39
ASP A  60
LEU A 100
 None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-3.6A)
SAH  A 328 ( 4.9A)
 0.74A 4fp9D-2i9kA:
8.3		 4fp9D-2i9kA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 GLY A  22
GLY A  23
ASN A  39
ASP A  60
PRO A  80
 None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-3.6A)
SAH  A 328 (-4.0A)
 0.74A 4fp9D-2i9kA:
8.3		 4fp9D-2i9kA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		6 / 12 GLY A  22
GLY A  23
ASN A  39
ASP A  60
PRO A  80
LEU A 100
 None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-3.6A)
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
 1.01A 4fzvA-2i9kA:
8.2		 4fzvA-2i9kA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 10 ILE A 169
LEU A   9
PHE A 117
SER A  30
ILE A 314
 None
 1.27A 4g8zX-2i9kA:
undetectable		 4g8zX-2i9kA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		3 / 3 GLU A  40
ASP A  42
ASP A  60
 SAH  A 328 (-2.8A)
None
SAH  A 328 (-3.6A)
 0.25A 4gc9A-2i9kA:
6.0		 4gc9A-2i9kA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 8 ILE A 314
LEU A 311
ILE A  74
PHE A  24
GLY A  78
 None
None
None
SAH  A 328 (-4.8A)
SAH  A 328 (-4.6A)
 1.14A 4hb8A-2i9kA:
undetectable		 4hb8A-2i9kA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 GLY A  20
GLY A  22
PHE A  24
ILE A  61
THR A  62
 SAH  A 328 (-3.3A)
None
SAH  A 328 (-4.8A)
SAH  A 328 (-4.3A)
SAH  A 328 ( 4.3A)
 0.59A 4n48A-2i9kA:
6.9		 4n48A-2i9kA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 GLY A  20
GLY A  22
PHE A  24
ILE A  61
THR A  62
 SAH  A 328 (-3.3A)
None
SAH  A 328 (-4.8A)
SAH  A 328 (-4.3A)
SAH  A 328 ( 4.3A)
 0.58A 4n48B-2i9kA:
7.1		 4n48B-2i9kA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 GLY A  20
GLY A  22
PHE A  24
ILE A  61
THR A  62
 SAH  A 328 (-3.3A)
None
SAH  A 328 (-4.8A)
SAH  A 328 (-4.3A)
SAH  A 328 ( 4.3A)
 0.64A 4n49A-2i9kA:
6.9		 4n49A-2i9kA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 GLY A  22
PHE A  24
ILE A  61
THR A  62
LEU A 100
 None
SAH  A 328 (-4.8A)
SAH  A 328 (-4.3A)
SAH  A 328 ( 4.3A)
SAH  A 328 ( 4.9A)
 0.77A 4n49A-2i9kA:
6.9		 4n49A-2i9kA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 10 VAL A 282
TYR A 265
LEU A 274
SER A 252
LEU A 251
 None
 1.11A 4ph9A-2i9kA:
undetectable		 4ph9A-2i9kA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 10 VAL A 282
TYR A 265
LEU A 274
SER A 252
LEU A 251
 None
 1.11A 4ph9B-2i9kA:
undetectable		 4ph9B-2i9kA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		3 / 3 SER A 305
TYR A 285
ASP A  16
 SAH  A 328 (-2.7A)
None
None
 0.90A 4rp8C-2i9kA:
undetectable		 4rp8C-2i9kA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		4 / 5 LYS A 112
PRO A 113
LEU A 143
TYR A 145
 None
 1.02A 4w5qA-2i9kA:
2.8		 4w5qA-2i9kA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		4 / 5 ILE A  69
ILE A  61
TYR A  37
GLU A  58
 None
SAH  A 328 (-4.3A)
None
None
 1.15A 4zzcE-2i9kA:
undetectable		 4zzcE-2i9kA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 GLY A 158
LEU A 251
TYR A 299
ILE A 207
GLY A 264
 None
 1.22A 5fsaB-2i9kA:
undetectable		 5fsaB-2i9kA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 ASP A  60
PRO A  80
PHE A  18
GLY A  20
GLU A  40
 SAH  A 328 (-3.6A)
SAH  A 328 (-4.0A)
SAH  A 328 (-4.9A)
SAH  A 328 (-3.3A)
SAH  A 328 (-2.8A)
 0.53A 5hfjA-2i9kA:
6.6		 5hfjA-2i9kA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 ASP A  60
PRO A  80
PHE A  18
GLY A  20
GLU A  40
 SAH  A 328 (-3.6A)
SAH  A 328 (-4.0A)
SAH  A 328 (-4.9A)
SAH  A 328 (-3.3A)
SAH  A 328 (-2.8A)
 0.44A 5hfjD-2i9kA:
2.1		 5hfjD-2i9kA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 ASP A  60
PRO A  80
PHE A  18
GLY A  20
GLU A  40
 SAH  A 328 (-3.6A)
SAH  A 328 (-4.0A)
SAH  A 328 (-4.9A)
SAH  A 328 (-3.3A)
SAH  A 328 (-2.8A)
 0.57A 5hfjF-2i9kA:
2.1		 5hfjF-2i9kA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 11 PHE A  18
GLY A  20
GLU A  40
ASP A  60
PRO A  80
 SAH  A 328 (-4.9A)
SAH  A 328 (-3.3A)
SAH  A 328 (-2.8A)
SAH  A 328 (-3.6A)
SAH  A 328 (-4.0A)
 0.57A 5hjiA-2i9kA:
9.5		 5hjiA-2i9kA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 ASP A  60
ILE A  61
PRO A  80
LEU A 100
PHE A  18
 SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
SAH  A 328 (-4.9A)
 0.87A 5il1A-2i9kA:
4.9		 5il1A-2i9kA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 ASP A  60
ILE A  61
PRO A  80
LEU A 100
PHE A  18
 SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
SAH  A 328 (-4.9A)
 0.88A 5k7uA-2i9kA:
undetectable		 5k7uA-2i9kA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		5 / 12 SER A  38
GLN A  46
CYH A  35
ALA A  77
ALA A  19
 None
 1.36A 5l5zH-2i9kA:
undetectable
5l5zI-2i9kA:
undetectable		 5l5zH-2i9kA:
18.63
5l5zI-2i9kA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		3 / 3 CYH A 170
MET A 140
ASN A 141
 None
 1.26A 5qh8A-2i9kA:
undetectable		 5qh8A-2i9kA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		3 / 3 VAL A 227
TYR A 242
GLU A 218
 None
 0.97A 5zmqD-2i9kA:
undetectable
5zmqE-2i9kA:
undetectable		 5zmqD-2i9kA:
20.65
5zmqE-2i9kA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		4 / 7 ALA A 315
PHE A  79
PHE A  14
ILE A 166
 None
 0.80A 6b5vA-2i9kA:
undetectable
6b5vB-2i9kA:
undetectable		 6b5vA-2i9kA:
16.32
6b5vB-2i9kA:
16.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		6 / 12 LEU A  21
GLY A  23
ASP A 103
ILE A 104
ASN A 304
SER A 305
 SAH  A 328 (-4.1A)
SAH  A 328 (-3.6A)
None
None
SAH  A 328 (-3.7A)
SAH  A 328 (-2.7A)
 1.37A 6mhtA-2i9kA:
44.8		 6mhtA-2i9kA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		12 / 12 PHE A  18
GLY A  20
LEU A  21
GLY A  23
ASN A  39
TRP A  41
ASP A  42
ASP A  60
ILE A  61
ASN A 304
SER A 305
VAL A 306
 SAH  A 328 (-4.9A)
SAH  A 328 (-3.3A)
SAH  A 328 (-4.1A)
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-3.4A)
None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-3.7A)
SAH  A 328 (-2.7A)
SAH  A 328 (-4.4A)
 0.56A 6mhtA-2i9kA:
44.8		 6mhtA-2i9kA:
99.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 2i9k MODIFICATION
METHYLASE HHAI
(Haemophilus
haemolyticus) 		3 / 3 ASP A  42
SER A 296
SER A 294
 None
 0.78A 6mxtA-2i9kA:
undetectable		 6mxtA-2i9kA:
19.67