SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ia0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 2ia0 PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PF0864
(Pyrococcus
furiosus) 		5 / 12 LEU A 124
LEU A  98
THR A 133
SER A 134
LEU A  73
 None
 1.06A 1ao8A-2ia0A:
undetectable		 1ao8A-2ia0A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 2ia0 PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PF0864
(Pyrococcus
furiosus) 		5 / 12 ALA A  97
SER A 134
ILE A 135
PRO A 136
LEU A  73
 None
 1.25A 1dlsA-2ia0A:
undetectable		 1dlsA-2ia0A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 2ia0 PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PF0864
(Pyrococcus
furiosus) 		4 / 6 LEU A  68
GLY A 117
LEU A 124
ILE A  71
 None
 0.91A 1yajF-2ia0A:
undetectable		 1yajF-2ia0A:
16.95