SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ia2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 2ia2 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		4 / 6 VAL A 107
VAL A 227
ASN A 228
ILE A 246
 None
 0.90A 1e06A-2ia2A:
undetectable		 1e06A-2ia2A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 2ia2 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		4 / 6 ASP A 120
GLY A 140
PRO A  93
ILE A 115
 None
 0.81A 1n49D-2ia2A:
undetectable		 1n49D-2ia2A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 2ia2 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 9 SER A 114
LEU A 201
ILE A 121
GLU A 257
GLY A 197
 None
 1.20A 2v0mB-2ia2A:
undetectable		 2v0mB-2ia2A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 2ia2 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		3 / 3 MET A 133
GLU A 109
ASP A 240
 None
 0.94A 3a25A-2ia2A:
undetectable		 3a25A-2ia2A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 2ia2 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		6 / 12 SER A 114
LEU A 201
ILE A 121
ALA A 145
GLU A 257
GLY A 197
 None
 1.31A 3nxuA-2ia2A:
undetectable		 3nxuA-2ia2A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2ia2 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		4 / 5 ARG A 217
GLY A 218
THR A 254
GLU A 257
 None
 1.09A 5btiA-2ia2A:
2.5
5btiB-2ia2A:
undetectable		 5btiA-2ia2A:
22.33
5btiB-2ia2A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2ia2 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		4 / 5 ARG A 217
GLY A 218
THR A 254
GLU A 257
 None
 1.13A 5btiC-2ia2A:
3.1
5btiD-2ia2A:
undetectable		 5btiC-2ia2A:
22.33
5btiD-2ia2A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 2ia2 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 12 SER A 114
LEU A 205
ILE A 121
ALA A 145
ILE A 190
 None
 1.10A 5vc0A-2ia2A:
undetectable		 5vc0A-2ia2A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 2ia2 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 12 LEU A 249
MET A 150
VAL A 153
SER A 112
GLU A 257
 None
 1.47A 5w8aA-2ia2A:
undetectable		 5w8aA-2ia2A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM7_A_ACTA603_0
(SALICYLATE-AMP
LIGASE)		 2ia2 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		4 / 4 THR A  49
THR A  52
ALA A  53
ARG A  22
 None
 1.47A 5wm7A-2ia2A:
undetectable		 5wm7A-2ia2A:
19.18