SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iab'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2iab HYPOTHETICAL PROTEIN
(Streptomyces
avermitilis) 		5 / 12 LEU A  46
GLY A  87
ALA A  26
ILE A  76
LEU A  20
 None
 1.01A 3adxB-2iabA:
undetectable		 3adxB-2iabA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 2iab HYPOTHETICAL PROTEIN
(Streptomyces
avermitilis) 		4 / 4 GLY A  75
VAL A  28
GLY A  87
THR A  88
 None
 0.94A 3ib2A-2iabA:
undetectable		 3ib2A-2iabA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 2iab HYPOTHETICAL PROTEIN
(Streptomyces
avermitilis) 		3 / 3 PHE A 105
ASP A 103
ARG A 114
 None
 0.76A 4eahF-2iabA:
undetectable		 4eahF-2iabA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 2iab HYPOTHETICAL PROTEIN
(Streptomyces
avermitilis) 		3 / 3 PHE A 105
ASP A 103
ARG A 114
 None
 0.76A 4eahG-2iabA:
undetectable		 4eahG-2iabA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2iab HYPOTHETICAL PROTEIN
(Streptomyces
avermitilis) 		4 / 7 THR A  62
LEU A  66
LEU A  74
THR A  30
 None
 0.82A 4z91F-2iabA:
undetectable
4z91G-2iabA:
undetectable
4z91H-2iabA:
undetectable
4z91I-2iabA:
undetectable
4z91J-2iabA:
undetectable		 4z91F-2iabA:
17.73
4z91G-2iabA:
17.73
4z91H-2iabA:
17.73
4z91I-2iabA:
17.73
4z91J-2iabA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2iab HYPOTHETICAL PROTEIN
(Streptomyces
avermitilis) 		4 / 6 ARG A 142
GLY A 141
SER A 140
LEU A 139
 None
 1.28A 5bphA-2iabA:
undetectable		 5bphA-2iabA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 2iab HYPOTHETICAL PROTEIN
(Streptomyces
avermitilis) 		4 / 5 PRO A 127
VAL A  85
GLY A  63
VAL A  54
 None
 1.07A 6ak3B-2iabA:
undetectable		 6ak3B-2iabA:
20.65