SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iaf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2iaf HYPOTHETICAL PROTEIN
SDHL
(Legionella
pneumophila) 		4 / 7 ILE A  78
LEU A  84
PHE A  94
THR A  50
 None
 1.21A 2zxwN-2iafA:
undetectable
2zxwW-2iafA:
undetectable		 2zxwN-2iafA:
14.20
2zxwW-2iafA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2iaf HYPOTHETICAL PROTEIN
SDHL
(Legionella
pneumophila) 		5 / 12 ALA A 119
LEU A  20
GLN A  19
VAL A  35
THR A  30
 None
 1.04A 3ix9A-2iafA:
undetectable		 3ix9A-2iafA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 2iaf HYPOTHETICAL PROTEIN
SDHL
(Legionella
pneumophila) 		5 / 10 ILE A 140
ALA A  13
LEU A  37
ILE A  78
ILE A  92
 None
 1.16A 3prsA-2iafA:
undetectable		 3prsA-2iafA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 2iaf HYPOTHETICAL PROTEIN
SDHL
(Legionella
pneumophila) 		3 / 3 LEU A  79
HIS A  76
MET A  75
 None
 0.81A 3thrD-2iafA:
undetectable		 3thrD-2iafA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 2iaf HYPOTHETICAL PROTEIN
SDHL
(Legionella
pneumophila) 		4 / 8 ALA A 119
THR A  30
LEU A  86
LEU A  58
 None
 0.89A 4ejgB-2iafA:
undetectable		 4ejgB-2iafA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2iaf HYPOTHETICAL PROTEIN
SDHL
(Legionella
pneumophila) 		3 / 3 HIS A 111
GLY A 136
ILE A 135
 None
 0.62A 4k50A-2iafA:
undetectable		 4k50A-2iafA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2iaf HYPOTHETICAL PROTEIN
SDHL
(Legionella
pneumophila) 		3 / 3 HIS A 111
GLY A 136
ILE A 135
 None
 0.60A 4k50I-2iafA:
undetectable		 4k50I-2iafA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2iaf HYPOTHETICAL PROTEIN
SDHL
(Legionella
pneumophila) 		4 / 8 PHE A 100
PHE A 102
GLY A  49
ILE A  72
 None
 0.98A 4qoiA-2iafA:
undetectable
4qoiB-2iafA:
undetectable		 4qoiA-2iafA:
21.03
4qoiB-2iafA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2iaf HYPOTHETICAL PROTEIN
SDHL
(Legionella
pneumophila) 		5 / 12 LEU A  84
PHE A 117
VAL A  33
THR A  44
GLY A  45
 None
 1.25A 5xipA-2iafA:
undetectable		 5xipA-2iafA:
15.29