SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iag'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		4 / 8 LEU A 172
ALA A 291
LEU A 217
LEU A 214
 None
HEM  A 600 ( 3.8A)
None
None
 0.92A 1dvtA-2iagA:
undetectable
1dvtB-2iagA:
undetectable		 1dvtA-2iagA:
13.45
1dvtB-2iagA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		4 / 4 LEU A 464
SER A 168
LEU A 466
LEU A 300
 None
 1.12A 1yajA-2iagA:
1.1		 1yajA-2iagA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		3 / 3 LEU A 214
LEU A 173
PHE A 108
 None
 0.72A 2pgrA-2iagA:
undetectable		 2pgrA-2iagA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		5 / 12 HIS A 461
LEU A 313
LEU A 295
PHE A 454
LEU A 148
 None
 1.40A 3adsA-2iagA:
undetectable		 3adsA-2iagA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		5 / 12 PHE A 167
HIS A 461
LEU A 313
LEU A 295
LEU A 148
 None
 1.49A 3adsA-2iagA:
undetectable		 3adsA-2iagA:
19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		4 / 6 ALA A 100
ALA A 283
THR A 284
ASN A 287
 None
HEM  A 600 (-4.4A)
HEM  A 600 (-3.9A)
HEM  A 600 (-4.2A)
 0.64A 3b6hA-2iagA:
59.8		 3b6hA-2iagA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		4 / 6 ALA A 100
ALA A 283
THR A 284
ASN A 287
 None
HEM  A 600 (-4.4A)
HEM  A 600 (-3.9A)
HEM  A 600 (-4.2A)
 0.70A 3b6hB-2iagA:
59.7		 3b6hB-2iagA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		5 / 11 LEU A 180
ALA A 447
ILE A 451
PHE A 454
THR A 127
 None
HEM  A 600 (-3.5A)
None
None
None
 1.27A 3qelA-2iagA:
undetectable
3qelB-2iagA:
undetectable		 3qelA-2iagA:
22.22
3qelB-2iagA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		4 / 8 ALA A 276
GLN A 280
LEU A 263
TYR A 259
 None
HEM  A 600 (-3.2A)
None
None
 1.00A 3qj7A-2iagA:
undetectable
3qj7D-2iagA:
undetectable		 3qj7A-2iagA:
20.29
3qj7D-2iagA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		4 / 5 ALA A 274
GLU A 270
GLU A 271
ALA A 244
 None
 1.41A 3r9tC-2iagA:
undetectable		 3r9tC-2iagA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		4 / 6 LEU A 427
ASP A  63
VAL A  86
ALA A  85
 None
 1.01A 4nkxA-2iagA:
27.2		 4nkxA-2iagA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		5 / 12 LEU A 384
ALA A 354
MET A 486
GLY A  47
ASP A  49
 None
 1.04A 4qckA-2iagA:
undetectable		 4qckA-2iagA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		5 / 12 TYR A 181
LEU A 128
LEU A 256
LEU A 246
ALA A 274
 None
 1.38A 4rtbA-2iagA:
undetectable		 4rtbA-2iagA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		3 / 3 ASP A 381
ARG A 378
TYR A  73
 None
 0.94A 5a7mA-2iagA:
undetectable		 5a7mA-2iagA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		3 / 3 ASP A 381
ARG A 378
TYR A  73
 None
 0.97A 5a7mB-2iagA:
undetectable		 5a7mB-2iagA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		5 / 12 LEU A 180
ALA A 447
ILE A 451
PHE A 454
THR A 127
 None
HEM  A 600 (-3.5A)
None
None
None
 1.24A 5ewjC-2iagA:
undetectable
5ewjD-2iagA:
undetectable		 5ewjC-2iagA:
22.94
5ewjD-2iagA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		3 / 3 LEU A 164
LEU A 464
ARG A 197
 None
 0.56A 5hnzB-2iagA:
undetectable		 5hnzB-2iagA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		3 / 3 LEU A 384
LEU A  54
ARG A  25
 None
 0.61A 5hnzB-2iagA:
undetectable		 5hnzB-2iagA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		5 / 12 VAL A 458
LEU A 345
LEU A 485
ALA A 292
LEU A 296
 None
 1.25A 5iktB-2iagA:
undetectable		 5iktB-2iagA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		5 / 9 PRO A 290
MET A 486
LEU A 295
SER A 348
ILE A 451
 None
 1.22A 6dm2A-2iagA:
undetectable
6dm2D-2iagA:
undetectable		 6dm2A-2iagA:
11.29
6dm2D-2iagA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens) 		5 / 9 ILE A 451
PRO A 290
MET A 486
LEU A 295
SER A 348
 None
 1.21A 6dm2B-2iagA:
undetectable
6dm2C-2iagA:
0.0		 6dm2B-2iagA:
11.29
6dm2C-2iagA:
11.29