SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iai'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 2iai PUTATIVE
TRANSCRIPTIONAL
REGULATOR SCO3833
(Streptomyces
coelicolor) 		3 / 3 MET A  32
LEU A  35
SER A  36
 None
 0.68A 1ee2A-2iaiA:
undetectable		 1ee2A-2iaiA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2iai PUTATIVE
TRANSCRIPTIONAL
REGULATOR SCO3833
(Streptomyces
coelicolor) 		5 / 12 MET A  93
ILE A 161
PHE A 127
ASP A 137
GLU A 141
 None
 1.45A 3aocC-2iaiA:
undetectable		 3aocC-2iaiA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 2iai PUTATIVE
TRANSCRIPTIONAL
REGULATOR SCO3833
(Streptomyces
coelicolor) 		5 / 9 ARG A  59
LEU A  15
VAL A  21
GLY A  40
ILE A  41
 None
 1.35A 3spkA-2iaiA:
undetectable		 3spkA-2iaiA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2iai PUTATIVE
TRANSCRIPTIONAL
REGULATOR SCO3833
(Streptomyces
coelicolor) 		4 / 8 SER A 163
MET A 160
ILE A 164
TRP A 167
 None
 1.08A 4cx7C-2iaiA:
undetectable
4cx7D-2iaiA:
undetectable		 4cx7C-2iaiA:
21.14
4cx7D-2iaiA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2iai PUTATIVE
TRANSCRIPTIONAL
REGULATOR SCO3833
(Streptomyces
coelicolor) 		5 / 11 GLY A 112
ASP A  28
PHE A  22
GLU A  54
VAL A  61
 None
 1.27A 5hw4B-2iaiA:
undetectable		 5hw4B-2iaiA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2iai PUTATIVE
TRANSCRIPTIONAL
REGULATOR SCO3833
(Streptomyces
coelicolor) 		5 / 12 GLY A 112
ASP A  28
PHE A  22
GLU A  54
VAL A  61
 None
 1.18A 5hw4C-2iaiA:
undetectable		 5hw4C-2iaiA:
24.72