SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ib5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2ib5 CHROMO PROTEIN
(Epiactis
japonica) 		4 / 8 HIS A 197
SER A 195
TYR A 178
PHE A  80
 CRQ  A  65 ( 3.7A)
None
None
None
 1.16A 1eqbA-2ib5A:
undetectable
1eqbB-2ib5A:
undetectable		 1eqbA-2ib5A:
19.95
1eqbB-2ib5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2ib5 CHROMO PROTEIN
(Epiactis
japonica) 		4 / 8 TYR A 178
PHE A  80
HIS A 197
SER A 195
 None
None
CRQ  A  65 ( 3.7A)
None
 1.19A 1eqbA-2ib5A:
undetectable
1eqbB-2ib5A:
undetectable		 1eqbA-2ib5A:
19.95
1eqbB-2ib5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2ib5 CHROMO PROTEIN
(Epiactis
japonica) 		4 / 8 HIS A 197
SER A 195
TYR A 178
PHE A  80
 CRQ  A  65 ( 3.7A)
None
None
None
 1.17A 1eqbC-2ib5A:
undetectable
1eqbD-2ib5A:
undetectable		 1eqbC-2ib5A:
19.95
1eqbD-2ib5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2ib5 CHROMO PROTEIN
(Epiactis
japonica) 		4 / 8 TYR A 178
PHE A  80
HIS A 197
SER A 195
 None
None
CRQ  A  65 ( 3.7A)
None
 1.18A 1eqbC-2ib5A:
undetectable
1eqbD-2ib5A:
undetectable		 1eqbC-2ib5A:
19.95
1eqbD-2ib5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2ib5 CHROMO PROTEIN
(Epiactis
japonica) 		4 / 8 GLN A 106
HIS A 197
SER A 195
TYR A  72
 CRQ  A  65 ( 4.1A)
CRQ  A  65 ( 3.7A)
None
None
 1.34A 1nx9A-2ib5A:
undetectable		 1nx9A-2ib5A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2ib5 CHROMO PROTEIN
(Epiactis
japonica) 		4 / 8 GLN A 106
HIS A 197
SER A 195
TYR A  72
 CRQ  A  65 ( 4.1A)
CRQ  A  65 ( 3.7A)
None
None
 1.33A 1nx9C-2ib5A:
undetectable		 1nx9C-2ib5A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2ib5 CHROMO PROTEIN
(Epiactis
japonica) 		4 / 8 GLN A 106
HIS A 197
SER A 195
TYR A  72
 CRQ  A  65 ( 4.1A)
CRQ  A  65 ( 3.7A)
None
None
 1.33A 1nx9D-2ib5A:
undetectable		 1nx9D-2ib5A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 2ib5 CHROMO PROTEIN
(Epiactis
japonica) 		4 / 7 THR A 108
TYR A 117
ASN A  61
LEU A  13
 None
CRQ  A  65 ( 4.1A)
None
None
 1.12A 1qzrB-2ib5A:
undetectable		 1qzrB-2ib5A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2ib5 CHROMO PROTEIN
(Epiactis
japonica) 		5 / 12 PHE A 211
THR A  59
ILE A 201
THR A 137
LEU A 162
 None
 0.97A 2rlcA-2ib5A:
undetectable		 2rlcA-2ib5A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 2ib5 CHROMO PROTEIN
(Epiactis
japonica) 		4 / 7 ILE A  57
LYS A  44
PHE A 211
GLY A 208
 None
 1.18A 3sj0X-2ib5A:
undetectable		 3sj0X-2ib5A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_B_TEPB402_1
(PYRIDOXAL KINASE)		 2ib5 CHROMO PROTEIN
(Epiactis
japonica) 		4 / 5 SER A  83
TYR A  79
VAL A  67
ASP A  78
 None
None
CRQ  A  65 ( 4.8A)
None
 1.18A 4eohB-2ib5A:
undetectable		 4eohB-2ib5A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 2ib5 CHROMO PROTEIN
(Epiactis
japonica) 		3 / 3 PRO A 190
MET A 189
TYR A  79
 None
 0.69A 4qa0B-2ib5A:
undetectable		 4qa0B-2ib5A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 2ib5 CHROMO PROTEIN
(Epiactis
japonica) 		3 / 3 PRO A 190
MET A 189
TYR A  79
 None
 0.69A 4qa0A-2ib5A:
undetectable		 4qa0A-2ib5A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 2ib5 CHROMO PROTEIN
(Epiactis
japonica) 		3 / 3 PRO A 190
MET A 189
TYR A  79
 None
 0.74A 4qa2B-2ib5A:
undetectable		 4qa2B-2ib5A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 2ib5 CHROMO PROTEIN
(Epiactis
japonica) 		3 / 3 MET A  25
GLN A 106
TYR A 117
 None
CRQ  A  65 ( 4.1A)
CRQ  A  65 ( 4.1A)
 1.00A 4udcA-2ib5A:
undetectable		 4udcA-2ib5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 2ib5 CHROMO PROTEIN
(Epiactis
japonica) 		4 / 4 THR A 149
LEU A 154
HIS A 193
GLY A 156
 None
 1.23A 5gwyA-2ib5A:
0.7		 5gwyA-2ib5A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2ib5 CHROMO PROTEIN
(Epiactis
japonica) 		3 / 3 THR A 137
PRO A 131
ASP A  98
 None
 0.93A 5l8dB-2ib5A:
undetectable		 5l8dB-2ib5A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2ib5 CHROMO PROTEIN
(Epiactis
japonica) 		3 / 3 THR A 137
PRO A 131
ASP A  98
 None
 0.93A 5mwuB-2ib5A:
undetectable		 5mwuB-2ib5A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2ib5 CHROMO PROTEIN
(Epiactis
japonica) 		4 / 8 LEU A  13
ILE A 119
ILE A 121
SER A  54
 None
 0.66A 5numA-2ib5A:
undetectable		 5numA-2ib5A:
19.68