SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ibb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2ibb CG9211-PA
(Drosophila
melanogaster) 		3 / 3 TYR A 613
HIS A 635
ARG A 637
 None
 1.03A 4htfA-2ibbA:
undetectable		 4htfA-2ibbA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2ibb CG9211-PA
(Drosophila
melanogaster) 		4 / 5 SER A 622
ARG A 672
GLY A 671
GLU A 589
 None
 1.04A 5btiA-2ibbA:
undetectable
5btiB-2ibbA:
undetectable		 5btiA-2ibbA:
17.23
5btiB-2ibbA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2ibb CG9211-PA
(Drosophila
melanogaster) 		4 / 5 SER A 622
ARG A 672
GLY A 671
GLU A 589
 None
 1.17A 5btiC-2ibbA:
undetectable
5btiD-2ibbA:
undetectable		 5btiC-2ibbA:
17.23
5btiD-2ibbA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ibb CG9211-PA
(Drosophila
melanogaster) 		5 / 12 ILE A 631
HIS A 598
VAL A 596
VAL A 595
SER A 638
 None
 1.18A 5n0sB-2ibbA:
undetectable		 5n0sB-2ibbA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 2ibb CG9211-PA
(Drosophila
melanogaster) 		3 / 3 PRO A 619
SER A 621
SER A 622
 None
 0.52A 6bpyA-2ibbA:
undetectable		 6bpyA-2ibbA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 2ibb CG9211-PA
(Drosophila
melanogaster) 		3 / 3 SER A 656
SER A 663
ALA A 602
 None
 0.73A 6dwnC-2ibbA:
undetectable		 6dwnC-2ibbA:
20.23