SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ic7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 2ic7 MALTOSE
TRANSACETYLASE
(Geobacillus
kaustophilus) 		5 / 11 GLY A 175
ALA A 161
ILE A 139
ALA A 155
ILE A 157
 None
 1.03A 2b60B-2ic7A:
undetectable		 2b60B-2ic7A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2ic7 MALTOSE
TRANSACETYLASE
(Geobacillus
kaustophilus) 		5 / 10 ILE A 103
VAL A 107
GLY A  87
VAL A  95
LEU A  50
 None
 1.28A 3elzC-2ic7A:
undetectable		 3elzC-2ic7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 2ic7 MALTOSE
TRANSACETYLASE
(Geobacillus
kaustophilus) 		4 / 8 GLY A 141
PHE A  54
GLY A  87
PHE A  67
 None
 0.98A 3ko0O-2ic7A:
undetectable
3ko0Q-2ic7A:
undetectable		 3ko0O-2ic7A:
18.09
3ko0Q-2ic7A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2ic7 MALTOSE
TRANSACETYLASE
(Geobacillus
kaustophilus) 		4 / 8 TYR A  73
LEU A  21
ASP A  18
SER A   3
 None
 1.01A 3rodA-2ic7A:
undetectable		 3rodA-2ic7A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2ic7 MALTOSE
TRANSACETYLASE
(Geobacillus
kaustophilus) 		6 / 12 ALA A 143
GLY A 175
ALA A 178
ALA A 155
ILE A 139
VAL A 172
 None
 1.34A 4nkxB-2ic7A:
undetectable		 4nkxB-2ic7A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2ic7 MALTOSE
TRANSACETYLASE
(Geobacillus
kaustophilus) 		5 / 12 ASP A  91
LEU A  90
GLY A  87
PHE A  67
LEU A  53
 None
 1.25A 4retA-2ic7A:
undetectable		 4retA-2ic7A:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2ic7 MALTOSE
TRANSACETYLASE
(Geobacillus
kaustophilus) 		5 / 12 ASP A  91
LEU A  90
GLY A  87
PHE A  67
LEU A  53
 None
 1.25A 4retC-2ic7A:
undetectable		 4retC-2ic7A:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2ic7 MALTOSE
TRANSACETYLASE
(Geobacillus
kaustophilus) 		5 / 12 ILE A 133
GLY A 134
ALA A 169
HIS A 100
ILE A 139
 None
 1.11A 4rvdA-2ic7A:
undetectable		 4rvdA-2ic7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 2ic7 MALTOSE
TRANSACETYLASE
(Geobacillus
kaustophilus) 		4 / 8 ASN A  84
PRO A 105
PHE A  82
TYR A  35
 None
 1.32A 5amkA-2ic7A:
undetectable		 5amkA-2ic7A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2ic7 MALTOSE
TRANSACETYLASE
(Geobacillus
kaustophilus) 		4 / 4 CYH A 101
PHE A  82
ILE A  89
GLY A 104
 None
 1.39A 5hesB-2ic7A:
undetectable		 5hesB-2ic7A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2ic7 MALTOSE
TRANSACETYLASE
(Geobacillus
kaustophilus) 		5 / 11 THR A 150
GLY A 134
ILE A  97
ILE A 109
ILE A 145
 None
 1.03A 6ebzA-2ic7A:
undetectable		 6ebzA-2ic7A:
17.24