SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2icg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 2icg LIN2918 PROTEIN
(Listeria
innocua) 		5 / 11 ILE A  66
GLY A  65
ILE A  97
LEU A  38
PHE A  42
 None
 1.00A 1z11B-2icgA:
undetectable		 1z11B-2icgA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 2icg LIN2918 PROTEIN
(Listeria
innocua) 		5 / 10 ILE A  66
GLY A  65
ILE A  97
LEU A  38
PHE A  42
 None
 1.06A 1z11D-2icgA:
undetectable		 1z11D-2icgA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 2icg LIN2918 PROTEIN
(Listeria
innocua) 		5 / 12 GLY A 116
PHE A 143
GLY A 119
PHE A  42
PHE A  49
 None
 1.01A 2dpmA-2icgA:
undetectable		 2dpmA-2icgA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2icg LIN2918 PROTEIN
(Listeria
innocua) 		5 / 12 GLY A  65
LEU A  56
ILE A  97
LEU A  38
PHE A 143
 None
 1.05A 5d4uA-2icgA:
undetectable		 5d4uA-2icgA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2icg LIN2918 PROTEIN
(Listeria
innocua) 		5 / 12 GLY A  65
LEU A  56
ILE A  97
LEU A  38
PHE A 143
 None
 1.07A 5d4uB-2icgA:
undetectable		 5d4uB-2icgA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2icg LIN2918 PROTEIN
(Listeria
innocua) 		4 / 5 ILE A  99
GLY A 144
ILE A 110
LEU A 147
 None
 0.75A 5dzkB-2icgA:
undetectable
5dzkI-2icgA:
undetectable
5dzkW-2icgA:
undetectable		 5dzkB-2icgA:
24.89
5dzkI-2icgA:
21.29
5dzkW-2icgA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2icg LIN2918 PROTEIN
(Listeria
innocua) 		4 / 4 ILE A  99
GLY A 144
ILE A 110
LEU A 147
 None
 0.71A 5dzkl-2icgA:
undetectable
5dzkz-2icgA:
undetectable		 5dzkl-2icgA:
21.29
5dzkz-2icgA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 2icg LIN2918 PROTEIN
(Listeria
innocua) 		3 / 3 ASN A 133
ASP A  91
GLY A  90
 None
 0.47A 5fctB-2icgA:
undetectable		 5fctB-2icgA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2icg LIN2918 PROTEIN
(Listeria
innocua) 		5 / 12 GLY A  60
GLU A 125
SER A 109
ILE A  99
PHE A 146
 None
 1.43A 5igwA-2icgA:
undetectable		 5igwA-2icgA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 2icg LIN2918 PROTEIN
(Listeria
innocua) 		5 / 12 ILE A 110
LEU A 147
PHE A  49
GLY A  65
ILE A  92
 None
 1.10A 6dwnC-2icgA:
undetectable		 6dwnC-2icgA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2icg LIN2918 PROTEIN
(Listeria
innocua) 		3 / 3 LEU A   6
SER A   4
PHE A   5
 None
 0.61A 6fgcA-2icgA:
undetectable		 6fgcA-2icgA:
17.18