SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ici'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 2ici EXOTOXIN I
(Streptococcus
pyogenes) 		3 / 3 ARG A  99
GLY A  25
ASP A  70
 None
 0.54A 1kf6A-2iciA:
undetectable
1kf6B-2iciA:
0.8		 1kf6A-2iciA:
17.58
1kf6B-2iciA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2ici EXOTOXIN I
(Streptococcus
pyogenes) 		4 / 8 LYS A 209
ILE A 135
GLU A 184
ILE A 186
 None
 0.93A 2j9dJ-2iciA:
undetectable
2j9dK-2iciA:
undetectable
2j9dL-2iciA:
undetectable		 2j9dJ-2iciA:
17.17
2j9dK-2iciA:
17.17
2j9dL-2iciA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 2ici EXOTOXIN I
(Streptococcus
pyogenes) 		5 / 11 THR A 193
LEU A 202
ILE A   9
THR A  21
GLU A  75
 None
 1.41A 3qelA-2iciA:
undetectable
3qelB-2iciA:
undetectable		 3qelA-2iciA:
21.19
3qelB-2iciA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2ici EXOTOXIN I
(Streptococcus
pyogenes) 		4 / 8 VAL A  53
LEU A  51
LEU A  74
THR A  73
 None
 0.70A 3roxA-2iciA:
undetectable		 3roxA-2iciA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 2ici EXOTOXIN I
(Streptococcus
pyogenes) 		5 / 12 THR A 193
LEU A 202
ILE A   9
THR A  21
GLU A  75
 None
 1.40A 5ewjC-2iciA:
undetectable
5ewjD-2iciA:
undetectable		 5ewjC-2iciA:
21.19
5ewjD-2iciA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2ici EXOTOXIN I
(Streptococcus
pyogenes) 		3 / 3 LEU A 146
LEU A 222
ARG A 163
 None
 0.57A 5hnzB-2iciA:
undetectable		 5hnzB-2iciA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 2ici EXOTOXIN I
(Streptococcus
pyogenes) 		4 / 8 TYR A  89
GLY A  91
ILE A  92
ASP A 207
 None
 1.06A 6ag0C-2iciA:
undetectable		 6ag0C-2iciA:
16.56