SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ick'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2ick ISOPENTENYL-DIPHOSPH
ATE DELTA ISOMERASE
(Homo
sapiens) 		4 / 7 ARG A  71
SER A  72
GLN A  14
GLU A 168
 DMA  A 301 (-2.6A)
None
DMA  A 301 ( 4.7A)
DMA  A 301 ( 4.7A)
 0.98A 2c8aA-2ickA:
undetectable		 2c8aA-2ickA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 2ick ISOPENTENYL-DIPHOSPH
ATE DELTA ISOMERASE
(Homo
sapiens) 		3 / 3 HIS A 148
GLU A 147
HIS A  41
 None
MN  A 229 ( 2.0A)
MN  A 229 (-3.4A)
 0.67A 3ba0A-2ickA:
undetectable		 3ba0A-2ickA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 2ick ISOPENTENYL-DIPHOSPH
ATE DELTA ISOMERASE
(Homo
sapiens) 		3 / 3 HIS A  41
HIS A  52
HIS A  89
 MN  A 229 (-3.4A)
MN  A 229 (-3.5A)
MN  A 229 ( 3.3A)
 0.60A 3qpkA-2ickA:
undetectable		 3qpkA-2ickA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 2ick ISOPENTENYL-DIPHOSPH
ATE DELTA ISOMERASE
(Homo
sapiens) 		3 / 3 HIS A  41
HIS A  52
HIS A  89
 MN  A 229 (-3.4A)
MN  A 229 (-3.5A)
MN  A 229 ( 3.3A)
 0.60A 3qpkB-2ickA:
undetectable		 3qpkB-2ickA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CLT_B_ACRB1000_1
(1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME)		 2ick ISOPENTENYL-DIPHOSPH
ATE DELTA ISOMERASE
(Homo
sapiens) 		5 / 10 ASN A 167
GLU A 168
LYS A  37
GLU A  20
ARG A 112
 None
DMA  A 301 ( 4.7A)
DMA  A 301 (-2.3A)
None
DMA  A 301 ( 4.6A)
 1.13A 5cltB-2ickA:
0.0		 5cltB-2ickA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2ick ISOPENTENYL-DIPHOSPH
ATE DELTA ISOMERASE
(Homo
sapiens) 		5 / 12 GLU A  96
ARG A  71
GLN A  69
ARG A 111
LEU A 113
 None
DMA  A 301 (-2.6A)
None
None
None
 1.45A 5m54B-2ickA:
undetectable		 5m54B-2ickA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 2ick ISOPENTENYL-DIPHOSPH
ATE DELTA ISOMERASE
(Homo
sapiens) 		4 / 8 HIS A  41
LEU A  51
GLY A  49
GLU A 149
 MN  A 229 (-3.4A)
None
None
DMA  A 301 ( 2.5A)
 0.85A 6mdqA-2ickA:
undetectable		 6mdqA-2ickA:
16.74