SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2icp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DUB_B_LDPB501_1 (CYTOCHROME P450 BM3 VARIANT 9D7)	2icp	ANTITOXIN HIGA (Escherichia coli)	4 / 6	PHE A 27 ALA A 38 GLY A 10 PRO A 9	None	0.88A	4dubB-2icpA: undetectable	4dubB-2icpA: 11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R3A_A_RBFA402_1 (BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2)	2icp	ANTITOXIN HIGA (Escherichia coli)	6 / 12	ALA A 46 ALA A 28 ILE A 33 ILE A 60 LEU A 56 MET A 52	None None MG A5001 ( 4.3A) None None None	1.23A	4r3aA-2icpA: undetectable	4r3aA-2icpA: 16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JNC_D_ACTD305_0 (CARBONIC ANHYDRASE 4)	2icp	ANTITOXIN HIGA (Escherichia coli)	4 / 5	PRO A 35 ALA A 38 ALA A 28 ILE A 33	None None None MG A5001 ( 4.3A)	0.71A	5jncD-2icpA: undetectable	5jncD-2icpA: 18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ODQ_A_ACTA703_0 (HETERODISULFIDE REDUCTASE, SUBUNIT A)	2icp	ANTITOXIN HIGA (Escherichia coli)	4 / 6	ARG A 25 ARG A 29 ALA A 28 PRO A 35	None	1.17A	5odqA-2icpA: undetectable	5odqA-2icpA: 9.74

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4DUB_B_LDPB501_1","CYTOCHROME P450 BM3 VARIANT 9D7","2icp","ANTITOXIN HIGA","Escherichia coli",4,"PHE A  27;ALA A  38;GLY A  10;PRO A   9","None","0.88A","4dubB-2icpA:undetectable","4dubB-2icpA:11.61"],["4R3A_A_RBFA402_1","BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2","2icp","ANTITOXIN HIGA","Escherichia coli",6,"ALA A  46;ALA A  28;ILE A  33;ILE A  60;LEU A  56;MET A  52","None;None; MG A5001 ( 4.3A);None;None;None","1.23A","4r3aA-2icpA:undetectable","4r3aA-2icpA:16.18"],["5JNC_D_ACTD305_0","CARBONIC ANHYDRASE 4","2icp","ANTITOXIN HIGA","Escherichia coli",4,"PRO A  35;ALA A  38;ALA A  28;ILE A  33","None;None;None; MG A5001 ( 4.3A)","0.71A","5jncD-2icpA:undetectable","5jncD-2icpA:18.42"],["5ODQ_A_ACTA703_0","HETERODISULFIDE REDUCTASE, SUBUNIT A","2icp","ANTITOXIN HIGA","Escherichia coli",4,"ARG A  25;ARG A  29;ALA A  28;PRO A  35","None","1.17A","5odqA-2icpA:undetectable","5odqA-2icpA:9.74"]]