SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ics'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 12 ASP A 330
VAL A  79
GLY A  78
ILE A  77
ILE A  57
 None
 0.92A 1fb7A-2icsA:
undetectable		 1fb7A-2icsA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 6 HIS A  60
HIS A  62
HIS A 188
HIS A 211
ASP A 272
 ZN  A 400 (-3.4A)
ZN  A 400 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 401 (-3.4A)
ZN  A 400 (-2.8A)
 0.81A 1fweC-2icsA:
21.2		 1fweC-2icsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		3 / 3 THR A 289
LEU A 293
VAL A 296
 None
 0.68A 1mz9E-2icsA:
undetectable		 1mz9E-2icsA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		3 / 3 LYS A 155
ASP A  88
ASN A 116
 KCX  A 154 ( 3.5A)
None
KCX  A 154 ( 4.3A)
 0.98A 2bm9A-2icsA:
undetectable		 2bm9A-2icsA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		4 / 7 LEU A 209
THR A 210
HIS A 188
GLY A 247
 None
KCX  A 154 ( 4.6A)
ZN  A 401 ( 3.2A)
None
 0.99A 2ddwB-2icsA:
undetectable		 2ddwB-2icsA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 12 HIS A 211
THR A 160
VAL A 161
GLN A 125
ILE A 122
 ZN  A 401 (-3.4A)
ADE  A1114 ( 4.3A)
None
ADE  A1114 (-3.3A)
None
 1.15A 2fj1A-2icsA:
undetectable		 2fj1A-2icsA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 12 HIS A 211
THR A 160
VAL A 161
GLN A 125
ILE A 122
 ZN  A 401 (-3.4A)
ADE  A1114 ( 4.3A)
None
ADE  A1114 (-3.3A)
None
 1.17A 2o7oA-2icsA:
0.0		 2o7oA-2icsA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 7 ILE A 117
PRO A 194
ILE A 199
LEU A 202
ILE A 167
 KCX  A 154 ( 4.0A)
None
None
None
None
 1.26A 2q83A-2icsA:
undetectable		 2q83A-2icsA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 12 HIS A 211
THR A 160
VAL A 161
GLN A 125
ILE A 122
 ZN  A 401 (-3.4A)
ADE  A1114 ( 4.3A)
None
ADE  A1114 (-3.3A)
None
 1.15A 2xpvA-2icsA:
0.3		 2xpvA-2icsA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 12 HIS A 211
THR A 160
VAL A 161
GLN A 125
ILE A 122
 ZN  A 401 (-3.4A)
ADE  A1114 ( 4.3A)
None
ADE  A1114 (-3.3A)
None
 1.11A 2xrlA-2icsA:
undetectable		 2xrlA-2icsA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		3 / 3 PRO A 184
LEU A 185
GLN A 177
 None
 0.73A 3hznG-2icsA:
undetectable
3hznH-2icsA:
undetectable		 3hznG-2icsA:
19.05
3hznH-2icsA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 12 HIS A 195
GLY A 166
LEU A 128
PRO A 169
ALA A 192
 None
 1.20A 3i5uA-2icsA:
undetectable		 3i5uA-2icsA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		4 / 5 HIS A  60
HIS A 188
HIS A 211
ASP A 272
 ZN  A 400 (-3.4A)
ZN  A 401 ( 3.2A)
ZN  A 401 (-3.4A)
ZN  A 400 (-2.8A)
 0.83A 4h9mA-2icsA:
22.1		 4h9mA-2icsA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		4 / 8 ILE A  24
ILE A 325
LYS A 309
GLY A 321
 None
 0.98A 4hdlA-2icsA:
undetectable		 4hdlA-2icsA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 12 ALA A 155
ALA A 136
ILE A 176
ASN A  96
GLY A  90
 KCX  A 154 ( 3.4A)
None
None
None
KCX  A 154 ( 3.6A)
 1.25A 4r38B-2icsA:
undetectable		 4r38B-2icsA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 6 HIS A  60
HIS A  62
HIS A 188
HIS A 211
ASP A 272
 ZN  A 400 (-3.4A)
ZN  A 400 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 401 (-3.4A)
ZN  A 400 (-2.8A)
 0.67A 4ubpC-2icsA:
20.4		 4ubpC-2icsA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 11 LEU A 200
PHE A 231
ASP A 230
GLN A 234
ALA A 235
 None
 1.24A 4uuuA-2icsA:
undetectable
4uuuB-2icsA:
undetectable		 4uuuA-2icsA:
17.94
4uuuB-2icsA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 11 LEU A 200
PHE A 231
ASP A 230
GLN A 234
ALA A 235
 None
 1.28A 4uuuB-2icsA:
undetectable		 4uuuB-2icsA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 12 HIS A 211
THR A 160
VAL A 161
GLN A 125
ILE A 122
 ZN  A 401 (-3.4A)
ADE  A1114 ( 4.3A)
None
ADE  A1114 (-3.3A)
None
 1.21A 4v2gB-2icsA:
0.3		 4v2gB-2icsA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 12 GLY A  82
TYR A 369
ILE A 360
THR A 332
GLY A 365
 None
 1.13A 5d4uA-2icsA:
undetectable		 5d4uA-2icsA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 12 GLY A  82
TYR A 369
ILE A 360
THR A 332
GLY A 365
 None
 1.12A 5d4uB-2icsA:
undetectable		 5d4uB-2icsA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		4 / 8 THR A  92
GLY A 113
ALA A 104
HIS A  62
 None
None
None
ZN  A 400 (-3.2A)
 0.97A 5eevL-2icsA:
undetectable
5eevV-2icsA:
undetectable		 5eevL-2icsA:
11.73
5eevV-2icsA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		4 / 8 THR A  92
GLY A 113
ALA A 104
HIS A  62
 None
None
None
ZN  A 400 (-3.2A)
 0.97A 5eewL-2icsA:
undetectable
5eewV-2icsA:
undetectable		 5eewL-2icsA:
11.73
5eewV-2icsA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		4 / 6 ASP A 243
GLY A 245
ASP A 272
ASP A  59
 None
None
ZN  A 400 (-2.8A)
None
 1.18A 5hp1A-2icsA:
undetectable		 5hp1A-2icsA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 12 ILE A 189
GLY A 219
ALA A 235
SER A 268
ILE A 244
 None
 1.21A 5igyA-2icsA:
undetectable		 5igyA-2icsA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 12 GLY A 113
VAL A 161
LEU A 128
GLY A 121
ILE A 122
 None
 1.09A 5vooF-2icsA:
4.1		 5vooF-2icsA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 10 PHE A 213
ASP A 272
GLY A 247
PHE A 251
ALA A  89
 None
ZN  A 400 (-2.8A)
None
None
KCX  A 154 ( 3.7A)
 1.25A 5x66D-2icsA:
undetectable		 5x66D-2icsA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 10 PHE A 213
ILE A 244
GLY A 247
PHE A 251
ALA A  89
 None
None
None
None
KCX  A 154 ( 3.7A)
 1.31A 5x66D-2icsA:
undetectable		 5x66D-2icsA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B50_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 12 PRO A 184
MET A 186
VAL A 150
VAL A 151
ASP A  88
 None
KCX  A 154 ( 3.9A)
None
None
None
 1.47A 6b50A-2icsA:
0.4		 6b50A-2icsA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		5 / 12 GLY A 121
GLY A 247
PRO A 282
ARG A 156
GLN A 125
 None
None
None
ADE  A1114 (-4.3A)
ADE  A1114 (-3.3A)
 1.11A 6gngB-2icsA:
undetectable		 6gngB-2icsA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2ics ADENINE DEAMINASE
(Enterococcus
faecalis) 		4 / 7 HIS A  62
THR A  91
ARG A 278
ASP A  72
 ZN  A 400 (-3.2A)
None
None
None
 1.36A 6mn4E-2icsA:
undetectable		 6mn4E-2icsA:
22.76