SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2icu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2icu HYPOTHETICAL PROTEIN
YEDK
(Escherichia
coli) 		4 / 6 ASP A 160
LEU A 163
VAL A 164
TRP A 110
 None
 0.76A 1s9qA-2icuA:
undetectable		 1s9qA-2icuA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_2
(NEURAMINIDASE)		 2icu HYPOTHETICAL PROTEIN
YEDK
(Escherichia
coli) 		4 / 5 LEU A  61
ARG A 184
ARG A 180
ILE A 187
 None
 1.47A 2cmlA-2icuA:
undetectable		 2cmlA-2icuA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_2
(NEURAMINIDASE)		 2icu HYPOTHETICAL PROTEIN
YEDK
(Escherichia
coli) 		4 / 5 LEU A  61
ARG A 184
ARG A 180
ILE A 187
 None
 1.42A 2cmlB-2icuA:
undetectable		 2cmlB-2icuA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_2
(NEURAMINIDASE)		 2icu HYPOTHETICAL PROTEIN
YEDK
(Escherichia
coli) 		4 / 5 LEU A  61
ARG A 184
ARG A 180
ILE A 187
 None
 1.37A 2cmlC-2icuA:
undetectable		 2cmlC-2icuA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_2
(NEURAMINIDASE)		 2icu HYPOTHETICAL PROTEIN
YEDK
(Escherichia
coli) 		4 / 5 LEU A  61
ARG A 184
ARG A 180
ILE A 187
 None
 1.40A 2cmlD-2icuA:
undetectable		 2cmlD-2icuA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 2icu HYPOTHETICAL PROTEIN
YEDK
(Escherichia
coli) 		5 / 12 ILE A 154
VAL A  66
LEU A  53
GLN A  14
PHE A  12
 None
 1.47A 2no0A-2icuA:
0.0		 2no0A-2icuA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 2icu HYPOTHETICAL PROTEIN
YEDK
(Escherichia
coli) 		5 / 12 ILE A 154
VAL A  66
LEU A  53
GLN A  14
PHE A  12
 None
 1.47A 2no0B-2icuA:
undetectable		 2no0B-2icuA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 2icu HYPOTHETICAL PROTEIN
YEDK
(Escherichia
coli) 		4 / 5 LEU A  61
ARG A 184
ARG A 180
ILE A 187
 None
 1.49A 3ticA-2icuA:
undetectable		 3ticA-2icuA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_2
(NEURAMINIDASE)		 2icu HYPOTHETICAL PROTEIN
YEDK
(Escherichia
coli) 		4 / 5 LEU A  61
ARG A 184
ARG A 180
ILE A 187
 None
 1.48A 3ticD-2icuA:
undetectable		 3ticD-2icuA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 2icu HYPOTHETICAL PROTEIN
YEDK
(Escherichia
coli) 		5 / 12 ILE A 154
PHE A 124
VAL A  51
TYR A  21
ILE A  40
 None
 1.10A 4g1bD-2icuA:
undetectable		 4g1bD-2icuA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2icu HYPOTHETICAL PROTEIN
YEDK
(Escherichia
coli) 		4 / 8 ILE A 138
ALA A  83
LEU A 153
ARG A 145
 None
 0.72A 4qrcA-2icuA:
undetectable		 4qrcA-2icuA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2icu HYPOTHETICAL PROTEIN
YEDK
(Escherichia
coli) 		4 / 5 LEU A  97
VAL A  66
TYR A  70
ARG A  31
 None
 1.04A 4r7iA-2icuA:
undetectable		 4r7iA-2icuA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2icu HYPOTHETICAL PROTEIN
YEDK
(Escherichia
coli) 		4 / 6 LEU A  53
VAL A  51
LEU A  80
GLU A 150
 None
 0.94A 5tudD-2icuA:
undetectable		 5tudD-2icuA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2icu HYPOTHETICAL PROTEIN
YEDK
(Escherichia
coli) 		4 / 5 PRO A  47
GLY A  48
THR A  49
LYS A  50
 None
 1.11A 5x23A-2icuA:
undetectable		 5x23A-2icuA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2icu HYPOTHETICAL PROTEIN
YEDK
(Escherichia
coli) 		4 / 6 PRO A  47
GLY A  48
THR A  49
LYS A  50
 None
 1.00A 5x24A-2icuA:
undetectable		 5x24A-2icuA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2icu HYPOTHETICAL PROTEIN
YEDK
(Escherichia
coli) 		4 / 6 PRO A  47
GLY A  48
THR A  49
LYS A  50
 None
 1.12A 5xxiA-2icuA:
undetectable		 5xxiA-2icuA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 2icu HYPOTHETICAL PROTEIN
YEDK
(Escherichia
coli) 		4 / 7 SER A 193
ARG A  84
ALA A  88
ALA A 157
 None
 0.90A 6ma7A-2icuA:
undetectable		 6ma7A-2icuA:
19.50