SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2icw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2icw T-CELL RECEPTOR BETA
CHAIN V
(Mus
musculus) 		4 / 6 GLY J  58
LEU J  45
TYR J  48
GLU J  42
 None
 0.96A 1fduD-2icwJ:
undetectable		 1fduD-2icwJ:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
(Mycoplasma
arthritidis) 		4 / 8 VAL G  52
VAL G  86
ILE G 100
LEU G 107
 None
 0.89A 1igxA-2icwG:
undetectable		 1igxA-2icwG:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
(Mycoplasma
arthritidis) 		3 / 3 TYR G  33
ARG G  57
GLN G  54
 None
 0.96A 1tw4A-2icwG:
undetectable		 1tw4A-2icwG:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_B_ADNB501_1
(HYPOTHETICAL PROTEIN
PH0463)		 2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
T-CELL RECEPTOR BETA
CHAIN V
(Mus
musculus;
Mycoplasma
arthritidis) 		5 / 11 HIS J  47
ILE J  60
ASP J  62
PRO J  61
ASN G  21
 None
 1.46A 1wu8B-2icwJ:
1.3
1wu8C-2icwJ:
1.2		 1wu8B-2icwJ:
18.82
1wu8C-2icwJ:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
T-CELL RECEPTOR BETA
CHAIN V
(Mycoplasma
arthritidis;
Mus
musculus) 		4 / 8 SER J  93
TYR J 100
TYR G 188
HIS J  29
 None
 1.35A 2bteA-2icwJ:
undetectable		 2bteA-2icwJ:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
T-CELL RECEPTOR BETA
CHAIN V
(Mycoplasma
arthritidis;
Mus
musculus) 		4 / 8 TYR J  33
TYR J 100
TYR G 188
HIS J  29
 None
 1.32A 2bteA-2icwJ:
undetectable		 2bteA-2icwJ:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
T-CELL RECEPTOR BETA
CHAIN V
(Mycoplasma
arthritidis;
Mus
musculus) 		4 / 8 SER J  93
TYR J 100
TYR G 188
HIS J  29
 None
 1.32A 2bteD-2icwJ:
undetectable		 2bteD-2icwJ:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
T-CELL RECEPTOR BETA
CHAIN V
(Mycoplasma
arthritidis;
Mus
musculus) 		4 / 8 TYR J  33
TYR J 100
TYR G 188
HIS J  29
 None
 1.34A 2bteD-2icwJ:
undetectable		 2bteD-2icwJ:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
T-CELL RECEPTOR BETA
CHAIN V
(Mycoplasma
arthritidis;
Mus
musculus) 		4 / 7 TYR J  33
TYR J 100
TYR G 188
HIS J  29
 None
 1.30A 2bytA-2icwJ:
undetectable		 2bytA-2icwJ:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
T-CELL RECEPTOR BETA
CHAIN V
(Mycoplasma
arthritidis;
Mus
musculus) 		4 / 7 TYR J  33
TYR J 100
TYR G 188
HIS J  29
 None
 1.31A 2bytD-2icwJ:
undetectable		 2bytD-2icwJ:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
T-CELL RECEPTOR BETA
CHAIN V
(Mycoplasma
arthritidis;
Mus
musculus) 		4 / 8 TYR J  33
TYR J 100
TYR G 188
HIS J  29
 None
 1.26A 2v0gA-2icwJ:
undetectable		 2v0gA-2icwJ:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
(Mycoplasma
arthritidis) 		3 / 3 LYS G 185
ILE G 122
PHE G 121
 None
 0.93A 3j7zS-2icwG:
undetectable
3j7za-2icwG:
undetectable		 3j7zS-2icwG:
21.66
3j7za-2icwG:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2icw T-CELL RECEPTOR BETA
CHAIN V
(Mus
musculus) 		3 / 3 TYR J  48
GLY J  58
ASP J  59
 None
 0.60A 3ou6C-2icwJ:
undetectable		 3ou6C-2icwJ:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 2icw T-CELL RECEPTOR BETA
CHAIN V
(Mus
musculus) 		4 / 7 GLU J  17
VAL J  19
LEU J  21
TYR J  89
 None
 1.06A 3qeoB-2icwJ:
undetectable		 3qeoB-2icwJ:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
(Mycoplasma
arthritidis) 		3 / 3 ASN G  67
LEU G 118
PHE G  60
 None
 0.67A 5dsgA-2icwG:
undetectable		 5dsgA-2icwG:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
T-CELL RECEPTOR BETA
CHAIN V
(Mycoplasma
arthritidis;
Mus
musculus) 		3 / 3 ASP G 155
ASN G 161
PHE J 101
 None
 0.89A 5jglB-2icwG:
undetectable		 5jglB-2icwG:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
(Mycoplasma
arthritidis) 		4 / 6 LEU G  83
SER G  84
PHE G  87
ASP G  88
 None
 0.75A 5om3A-2icwG:
undetectable
5om3B-2icwG:
undetectable		 5om3A-2icwG:
19.52
5om3B-2icwG:
11.22