SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2icy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 7 GLY A  87
THR A 143
HIS A 140
THR A 139
 UPG  A 901 (-3.9A)
None
None
None
 0.88A 1gtfL-2icyA:
undetectable
1gtfM-2icyA:
undetectable		 1gtfL-2icyA:
12.69
1gtfM-2icyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 8 GLY A  87
THR A 143
HIS A 140
THR A 139
 UPG  A 901 (-3.9A)
None
None
None
 0.87A 1gtfN-2icyA:
undetectable
1gtfO-2icyA:
undetectable		 1gtfN-2icyA:
12.69
1gtfO-2icyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 8 LEU A 375
LEU A 224
GLY A 225
ILE A 227
 None
 0.89A 1n13A-2icyA:
undetectable
1n13F-2icyA:
undetectable		 1n13A-2icyA:
6.82
1n13F-2icyA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 5 ILE A 394
PHE A 406
PHE A 400
ILE A 413
 None
 1.11A 2hjhA-2icyA:
undetectable		 2hjhA-2icyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 MET A 315
THR A 334
LEU A 297
ILE A 304
PRO A 189
 None
None
None
None
UPG  A 901 (-4.1A)
 1.12A 2qxsB-2icyA:
undetectable		 2qxsB-2icyA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 TYR A 243
PHE A 343
LEU A 301
PHE A 196
ILE A 304
 None
 1.21A 2y7kD-2icyA:
1.0		 2y7kD-2icyA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 THR A  73
ASP A 229
LEU A  80
ASN A 154
TYR A 125
 None
 1.22A 2zw9B-2icyA:
2.6		 2zw9B-2icyA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 ILE A 434
ASN A 383
ILE A 413
VAL A 424
LEU A 422
 None
 1.11A 3a51D-2icyA:
undetectable		 3a51D-2icyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		3 / 3 PRO A 358
LEU A 357
ARG A 382
 None
 0.86A 3aqiA-2icyA:
2.8		 3aqiA-2icyA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 8 LEU A 301
VAL A 218
LEU A  83
VAL A 195
LEU A 199
 None
 1.14A 3kp6A-2icyA:
undetectable
3kp6B-2icyA:
undetectable		 3kp6A-2icyA:
18.04
3kp6B-2icyA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 6 GLU A 316
PHE A 342
ALA A 338
ALA A 339
 None
 1.24A 3ns1C-2icyA:
undetectable		 3ns1C-2icyA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		3 / 3 SER A 285
PHE A 289
LYS A 290
 None
 0.95A 3u88A-2icyA:
undetectable		 3u88A-2icyA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		3 / 3 SER A 408
PHE A 410
LYS A 411
 None
 0.97A 3u88A-2icyA:
undetectable		 3u88A-2icyA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		3 / 3 VAL A 324
GLY A 326
LYS A 328
 None
 0.77A 4k50E-2icyA:
undetectable		 4k50E-2icyA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 8 VAL A  82
LEU A  80
ILE A 237
VAL A  66
 None
 0.96A 4ma7A-2icyA:
undetectable		 4ma7A-2icyA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 ASN A 295
GLY A 337
ALA A 338
ALA A 273
ILE A 317
 UPG  A 901 (-3.0A)
None
None
None
None
 0.94A 4nkxB-2icyA:
undetectable		 4nkxB-2icyA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 ASN A 295
GLY A 337
ALA A 338
ALA A 273
ILE A 317
 UPG  A 901 (-3.0A)
None
None
None
None
 0.91A 4nkxC-2icyA:
undetectable		 4nkxC-2icyA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 ASN A 295
GLY A 337
ALA A 338
ALA A 273
ILE A 317
 UPG  A 901 (-3.0A)
None
None
None
None
 0.91A 4nkxD-2icyA:
undetectable		 4nkxD-2icyA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 9 PHE A 343
ASN A 295
GLY A 337
THR A 334
VAL A 195
 None
UPG  A 901 (-3.0A)
None
None
None
 1.21A 4r20B-2icyA:
undetectable		 4r20B-2icyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 THR A 334
ILE A  30
PRO A 166
ARG A  35
VAL A  33
 None
 1.04A 4rvgA-2icyA:
undetectable		 4rvgA-2icyA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		3 / 3 LEU A  76
VAL A  70
ASP A  69
 None
 0.67A 4y8wC-2icyA:
undetectable		 4y8wC-2icyA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		3 / 3 PHE A 110
ILE A 102
ASP A 142
 None
 0.71A 5cswA-2icyA:
undetectable		 5cswA-2icyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		3 / 3 PHE A 110
ILE A 102
ASP A 142
 None
 0.67A 5cswB-2icyA:
undetectable		 5cswB-2icyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 8 GLY A  87
THR A 143
HIS A 140
THR A 139
 UPG  A 901 (-3.9A)
None
None
None
 0.86A 5eevL-2icyA:
undetectable
5eevV-2icyA:
undetectable		 5eevL-2icyA:
12.69
5eevV-2icyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 8 GLY A  87
THR A 143
HIS A 140
THR A 139
 UPG  A 901 (-3.9A)
None
None
None
 0.86A 5eewL-2icyA:
undetectable
5eewV-2icyA:
undetectable		 5eewL-2icyA:
12.69
5eewV-2icyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 8 GLY A  87
THR A 143
HIS A 140
THR A 139
 UPG  A 901 (-3.9A)
None
None
None
 0.86A 5eezL-2icyA:
undetectable
5eezV-2icyA:
undetectable		 5eezL-2icyA:
12.69
5eezV-2icyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 8 GLY A  87
THR A 143
HIS A 140
THR A 139
 UPG  A 901 (-3.9A)
None
None
None
 0.86A 5ef1L-2icyA:
undetectable
5ef1V-2icyA:
undetectable		 5ef1L-2icyA:
12.69
5ef1V-2icyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 8 GLY A  87
THR A 143
HIS A 140
THR A 139
 UPG  A 901 (-3.9A)
None
None
None
 0.85A 5ef2L-2icyA:
undetectable
5ef2V-2icyA:
undetectable		 5ef2L-2icyA:
12.69
5ef2V-2icyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 8 GLY A  87
THR A 143
HIS A 140
THR A 139
 UPG  A 901 (-3.9A)
None
None
None
 0.86A 5ef3L-2icyA:
undetectable
5ef3V-2icyA:
undetectable		 5ef3L-2icyA:
12.69
5ef3V-2icyA:
12.69