SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2id0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		4 / 7 VAL A 569
VAL A 610
ILE A 624
LEU A 601
 None
 0.90A 1iepB-2id0A:
undetectable		 1iepB-2id0A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		3 / 3 GLN A  50
LYS A  52
VAL A  54
 None
 0.70A 2jfaB-2id0A:
undetectable		 2jfaB-2id0A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		4 / 6 LEU A 224
MET A 286
LEU A 288
GLU A 391
 None
 1.20A 2kuhA-2id0A:
undetectable		 2kuhA-2id0A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		4 / 7 ILE A  60
LEU A 137
MET A  51
LEU A 106
 None
 0.98A 3adxA-2id0A:
undetectable		 3adxA-2id0A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		3 / 3 LEU A 224
GLU A 391
ILE A 388
 None
 0.47A 3czhA-2id0A:
undetectable		 3czhA-2id0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		4 / 4 ILE A 477
GLN A 530
ILE A 506
LEU A 537
 None
 1.23A 3dzyD-2id0A:
undetectable		 3dzyD-2id0A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		6 / 10 GLY A 584
ALA A 585
GLY A 546
LEU A 549
VAL A 631
ILE A 638
 None
 1.38A 3em3A-2id0A:
undetectable		 3em3A-2id0A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		5 / 9 ALA A 585
GLY A 546
LEU A 549
VAL A 631
ILE A 638
 None
 1.10A 3em4B-2id0A:
undetectable		 3em4B-2id0A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		6 / 11 GLY A 584
ALA A 585
GLY A 546
LEU A 549
VAL A 631
ILE A 638
 None
 1.41A 3em4U-2id0A:
undetectable		 3em4U-2id0A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		5 / 8 GLY A 584
ALA A 585
GLY A 546
LEU A 549
VAL A 631
 None
 1.43A 3em6A-2id0A:
undetectable		 3em6A-2id0A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		3 / 3 LEU A 262
PRO A 263
LEU A 266
 None
 0.51A 3hcrA-2id0A:
undetectable		 3hcrA-2id0A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		3 / 3 HIS A 157
ARG A 552
GLU A 373
 None
 0.97A 3qf1A-2id0A:
undetectable		 3qf1A-2id0A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		4 / 6 ALA A  62
ILE A  60
LEU A  36
GLU A  74
 None
 0.83A 3r9sA-2id0A:
undetectable		 3r9sA-2id0A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		4 / 6 ALA A  62
ILE A  60
LEU A  36
GLU A  74
 None
 0.81A 3r9sC-2id0A:
undetectable		 3r9sC-2id0A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		4 / 8 ALA A 229
VAL A 281
ASP A 230
LEU A 270
 None
 0.84A 3roxA-2id0A:
undetectable		 3roxA-2id0A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		3 / 3 SER A 202
ASP A 209
ASP A 504
 None
MN  A1001 (-3.9A)
None
 0.79A 3uj7A-2id0A:
undetectable		 3uj7A-2id0A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		4 / 7 GLY A  24
ASP A  58
VAL A  26
HIS A 135
 None
 0.81A 4c5nA-2id0A:
undetectable		 4c5nA-2id0A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		4 / 8 LEU A 282
THR A 494
TRP A 495
ASP A 504
 None
 1.06A 4drjB-2id0A:
undetectable		 4drjB-2id0A:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		4 / 6 PHE A 301
ALA A 303
ALA A 227
LEU A 192
 None
 1.08A 4dtzB-2id0A:
undetectable		 4dtzB-2id0A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		3 / 3 PHE A 553
TYR A 364
TYR A 550
 None
 0.88A 4ffwA-2id0A:
undetectable		 4ffwA-2id0A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		4 / 8 VAL A  26
LEU A  36
TYR A  44
ILE A  64
 None
 0.95A 4ma7A-2id0A:
undetectable		 4ma7A-2id0A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		3 / 3 SER A 202
ASP A 209
ASP A 504
 None
MN  A1001 (-3.9A)
None
 0.83A 4mwzA-2id0A:
undetectable		 4mwzA-2id0A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		4 / 6 CYH A 344
ILE A 343
GLN A 342
ILE A 384
 None
 1.15A 4w5tA-2id0A:
undetectable		 4w5tA-2id0A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		5 / 12 LEU A 282
HIS A 508
ILE A 515
ASN A 507
LEU A 404
 None
 1.20A 4yvpB-2id0A:
undetectable		 4yvpB-2id0A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		4 / 6 CYH A 344
ILE A 343
GLN A 342
ILE A 384
 None
 1.20A 6cbdA-2id0A:
undetectable		 6cbdA-2id0A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		5 / 10 PHE A 197
LEU A 212
THR A 199
ILE A 305
ILE A 228
 None
 1.11A 6ebpB-2id0A:
undetectable		 6ebpB-2id0A:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2id0 EXORIBONUCLEASE 2
(Escherichia
coli) 		5 / 10 PHE A 197
LEU A 212
THR A 199
ILE A 305
ILE A 228
 None
 1.13A 6ebpC-2id0A:
undetectable		 6ebpC-2id0A:
7.22