SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2id3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 2id3 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 LEU A 127
ALA A  74
LEU A  24
ARG A  20
LEU A 109
 None
 1.40A 1ya3B-2id3A:
undetectable		 1ya3B-2id3A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 2id3 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 LEU A 127
ALA A  74
LEU A  24
ARG A  20
LEU A 109
 None
 1.41A 2oaxC-2id3A:
undetectable		 2oaxC-2id3A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 2id3 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 LEU A 127
ALA A  74
LEU A  24
ARG A  20
LEU A 109
 None
 1.40A 2oaxD-2id3A:
undetectable		 2oaxD-2id3A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2id3 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 5 LEU A  70
VAL A 160
LEU A  90
ARG A 143
 None
 1.11A 2oiqA-2id3A:
undetectable		 2oiqA-2id3A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 2id3 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 5 ILE A  44
LEU A  41
ASP A  68
ALA A  27
 None
CL  A 611 (-3.8A)
None
None
 0.95A 2opxA-2id3A:
undetectable		 2opxA-2id3A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 2id3 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 6 ALA A  92
ASN A  93
LEU A  96
VAL A  97
 None
 0.75A 4g24A-2id3A:
undetectable		 4g24A-2id3A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2id3 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 4 ASP A  89
LEU A  90
ARG A 134
THR A  83
 None
None
CL  A 610 ( 4.6A)
None
 1.39A 4kjjA-2id3A:
undetectable		 4kjjA-2id3A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2id3 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 4 ASP A  89
LEU A  90
ARG A 134
THR A  83
 None
None
CL  A 610 ( 4.6A)
None
 1.40A 4kjkA-2id3A:
undetectable		 4kjkA-2id3A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2id3 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 5 ASP A  89
LEU A  90
ARG A 134
THR A  83
 None
None
CL  A 610 ( 4.6A)
None
 1.47A 4p3qA-2id3A:
undetectable		 4p3qA-2id3A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 2id3 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 GLY A  28
PHE A  36
GLY A  64
LEU A  41
PRO A  62
 None
None
None
CL  A 611 (-3.8A)
CL  A 611 ( 4.3A)
 1.45A 4uinH-2id3A:
undetectable
4uinL-2id3A:
undetectable		 4uinH-2id3A:
18.78
4uinL-2id3A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2id3 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 7 LEU A  39
ALA A  30
ALA A  48
LEU A  65
 None
 0.60A 4z90F-2id3A:
2.6
4z90G-2id3A:
2.7
4z90H-2id3A:
2.6
4z90J-2id3A:
2.6		 4z90F-2id3A:
18.83
4z90G-2id3A:
18.83
4z90H-2id3A:
18.83
4z90J-2id3A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2id3 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 9 ALA A  27
ALA A  30
GLY A  64
GLY A  63
ALA A  66
 None
 1.08A 5d0xK-2id3A:
undetectable
5d0xL-2id3A:
undetectable		 5d0xK-2id3A:
19.82
5d0xL-2id3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2id3 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 9 ALA A  27
ALA A  30
GLY A  64
GLY A  63
ALA A  66
 None
 1.09A 5d0xY-2id3A:
undetectable
5d0xZ-2id3A:
undetectable		 5d0xY-2id3A:
19.82
5d0xZ-2id3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2id3 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 VAL A  55
LEU A  65
ALA A  17
GLY A  49
ALA A  48
 None
 1.03A 5jw1A-2id3A:
2.2		 5jw1A-2id3A:
17.03