SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2id5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		4 / 4 THR A 310
LEU A 308
VAL A 303
LEU A 279
 None
 1.12A 1fbmB-2id5A:
undetectable		 1fbmB-2id5A:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		5 / 11 LEU A  37
VAL A  16
GLU A  33
LYS A   1
PHE A  23
 None
 1.43A 1gx9A-2id5A:
undetectable		 1gx9A-2id5A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		5 / 11 ILE A 207
LEU A 247
PRO A 240
LEU A 255
ASN A 225
 None
None
None
None
NAG  A 488 (-1.8A)
 1.17A 1mrlA-2id5A:
undetectable
1mrlB-2id5A:
undetectable		 1mrlA-2id5A:
15.72
1mrlB-2id5A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		5 / 12 ILE A 207
LEU A 247
PRO A 240
LEU A 255
ASN A 225
 None
None
None
None
NAG  A 488 (-1.8A)
 1.19A 1mrlB-2id5A:
undetectable
1mrlC-2id5A:
undetectable		 1mrlB-2id5A:
15.72
1mrlC-2id5A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		5 / 12 LEU A 253
LEU A 229
LEU A 205
MET A 216
LEU A 236
 None
 1.09A 1sqnB-2id5A:
undetectable		 1sqnB-2id5A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		4 / 8 ASP A 121
THR A 169
PRO A 168
LEU A 164
 None
 0.80A 1z2bB-2id5A:
undetectable		 1z2bB-2id5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		5 / 12 ILE A 167
LEU A 221
THR A 217
PRO A 240
LEU A 213
 None
 1.03A 2cd2A-2id5A:
undetectable		 2cd2A-2id5A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		4 / 7 PHE A 292
LEU A 301
LEU A 325
GLU A 288
 None
 0.89A 2jn3A-2id5A:
undetectable		 2jn3A-2id5A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		5 / 12 PHE A  52
LEU A  39
ILE A  44
GLY A  86
LEU A  82
 None
 1.20A 2lbdA-2id5A:
undetectable		 2lbdA-2id5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		5 / 12 LEU A 284
VAL A 287
ILE A 277
LEU A 301
PHE A 292
 None
 1.15A 2qk8A-2id5A:
undetectable		 2qk8A-2id5A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		4 / 8 LEU A 274
ILE A 277
LEU A 253
LEU A 271
 None
 0.81A 2xfhA-2id5A:
undetectable		 2xfhA-2id5A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		5 / 9 LEU A 284
VAL A 287
ILE A 277
LEU A 301
PHE A 292
 None
 1.15A 3fl9H-2id5A:
undetectable		 3fl9H-2id5A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		3 / 3 ARG A  88
GLU A  60
ASP A  13
 None
 0.90A 3g2oA-2id5A:
undetectable		 3g2oA-2id5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		5 / 12 LEU A 255
GLY A 282
GLY A 281
ILE A 231
ASN A 235
 None
None
None
None
NAG  A 486 (-1.8A)
 0.93A 3nk7A-2id5A:
undetectable		 3nk7A-2id5A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		3 / 3 HIS A 185
SER A 112
GLU A 113
 None
 0.73A 3s8pA-2id5A:
undetectable		 3s8pA-2id5A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		3 / 3 HIS A 209
SER A 230
GLU A 206
 None
 0.85A 3s8pA-2id5A:
undetectable		 3s8pA-2id5A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		5 / 12 VAL A  68
PHE A  76
ILE A 111
ILE A  95
LEU A 103
 None
 1.25A 3w67D-2id5A:
undetectable		 3w67D-2id5A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		4 / 8 TYR A 241
THR A 237
LEU A 213
MET A 216
 None
 1.09A 3wipG-2id5A:
undetectable
3wipH-2id5A:
undetectable		 3wipG-2id5A:
19.25
3wipH-2id5A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		4 / 8 LEU A 213
MET A 216
TYR A 241
THR A 237
 None
 1.31A 3wipF-2id5A:
undetectable
3wipJ-2id5A:
undetectable		 3wipF-2id5A:
19.25
3wipJ-2id5A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		5 / 12 ILE A  95
LEU A 109
LEU A  85
GLY A  86
VAL A  68
 None
 1.04A 4c9lB-2id5A:
undetectable		 4c9lB-2id5A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		3 / 3 TYR A 456
ARG A 423
SER A 421
 None
 0.81A 4khpI-2id5A:
undetectable
4khpJ-2id5A:
undetectable		 4khpI-2id5A:
14.26
4khpJ-2id5A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		4 / 8 LEU A 295
LEU A 298
LEU A 322
VAL A 287
 None
 0.80A 4klaA-2id5A:
undetectable		 4klaA-2id5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		5 / 9 LEU A 186
PRO A 168
ALA A 147
PHE A 148
LEU A 181
 None
 1.48A 4la0B-2id5A:
undetectable		 4la0B-2id5A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		5 / 11 LEU A 322
VAL A 303
LEU A 327
LEU A 298
LEU A 348
 None
 1.28A 4or0B-2id5A:
undetectable		 4or0B-2id5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		4 / 8 ASN A  42
ILE A  44
GLU A  62
GLY A  40
 None
 0.80A 4r20A-2id5A:
undetectable		 4r20A-2id5A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		4 / 7 LEU A 164
ALA A 171
ALA A 147
LEU A 140
 None
 0.61A 4z90F-2id5A:
undetectable
4z90G-2id5A:
undetectable
4z90H-2id5A:
undetectable
4z90J-2id5A:
undetectable		 4z90F-2id5A:
22.00
4z90G-2id5A:
22.00
4z90H-2id5A:
22.00
4z90J-2id5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		5 / 8 LEU A 322
PHE A 292
ILE A 277
PHE A 316
LEU A 327
 None
 1.33A 5eseA-2id5A:
undetectable		 5eseA-2id5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		4 / 6 LEU A 242
LEU A 271
LEU A 268
HIS A 246
 None
 0.97A 5gs4A-2id5A:
undetectable		 5gs4A-2id5A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		5 / 8 ALA A 171
LEU A 178
LEU A 199
LEU A 159
LEU A 157
 None
 1.18A 5jqbA-2id5A:
undetectable
5jqbB-2id5A:
undetectable		 5jqbA-2id5A:
19.84
5jqbB-2id5A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		3 / 3 LYS A 161
ASP A 137
ILE A 188
 None
 0.86A 5kc4E-2id5A:
undetectable		 5kc4E-2id5A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		4 / 8 VAL A  99
GLY A  86
LEU A 109
THR A  84
 None
 0.96A 5sxqA-2id5A:
undetectable		 5sxqA-2id5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		4 / 8 VAL A  99
GLY A  86
LEU A 109
THR A  84
 None
 0.91A 5sxqB-2id5A:
undetectable		 5sxqB-2id5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		4 / 8 VAL A  99
GLY A  86
LEU A 109
THR A  84
 None
 0.98A 5sxtA-2id5A:
undetectable		 5sxtA-2id5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		4 / 8 VAL A  99
GLY A  86
LEU A 109
THR A  84
 None
 0.96A 5sxtB-2id5A:
undetectable		 5sxtB-2id5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		4 / 8 VAL A  99
GLY A  86
LEU A 109
THR A  84
 None
 0.95A 5syjA-2id5A:
undetectable		 5syjA-2id5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		4 / 8 VAL A  99
GLY A  86
LEU A 109
THR A  84
 None
 0.90A 5syjB-2id5A:
undetectable		 5syjB-2id5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		4 / 5 ARG A 192
MET A 216
THR A 215
LEU A 213
 None
 1.27A 5x1bW-2id5A:
undetectable		 5x1bW-2id5A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		3 / 3 ARG A 201
LYS A 203
ARG A 245
 None
NAG  A 488 (-3.9A)
None
 1.32A 6c06D-2id5A:
undetectable		 6c06D-2id5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		4 / 8 LEU A 154
LEU A 130
LEU A 159
GLY A 136
 None
 0.87A 6ce2A-2id5A:
undetectable		 6ce2A-2id5A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		5 / 12 VAL A 341
LEU A 327
PHE A 350
PHE A 316
VAL A 315
 None
 1.16A 6drzA-2id5A:
undetectable		 6drzA-2id5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens) 		5 / 7 LEU A 172
VAL A 135
LEU A 157
LEU A 154
LEU A 119
 None
 0.70A 6g9bA-2id5A:
undetectable
6g9bB-2id5A:
undetectable		 6g9bA-2id5A:
10.93
6g9bB-2id5A:
11.62