SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ido'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2ido DNA POLYMERASE III
EPSILON SUBUNIT
(Escherichia
coli) 		5 / 11 LEU A 166
LEU A 165
ALA A 168
ILE A 154
LEU A 145
 None
 1.28A 1g50A-2idoA:
undetectable		 1g50A-2idoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2ido DNA POLYMERASE III
EPSILON SUBUNIT
(Escherichia
coli) 		4 / 6 ASP A  12
LEU A  11
VAL A  10
ILE A   9
 MN  A1001 (-2.6A)
None
None
None
 0.99A 1s9qA-2idoA:
undetectable		 1s9qA-2idoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 2ido DNA POLYMERASE III
EPSILON SUBUNIT
(Escherichia
coli) 		3 / 3 LYS A  76
PRO A  77
LEU A  52
 None
 0.81A 3tpxE-2idoA:
undetectable		 3tpxE-2idoA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2ido DNA POLYMERASE III
EPSILON SUBUNIT
HOT PROTEIN
(Escherichia
coli;
Escherichia
virus
P1) 		3 / 3 TYR A  51
GLU A  71
TYR B  28
 None
 0.89A 3ug8A-2idoA:
undetectable		 3ug8A-2idoA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 2ido DNA POLYMERASE III
EPSILON SUBUNIT
(Escherichia
coli) 		5 / 7 PHE A  79
PHE A 111
THR A 121
ILE A  90
PHE A  86
 None
 1.29A 4ejjA-2idoA:
undetectable		 4ejjA-2idoA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 2ido DNA POLYMERASE III
EPSILON SUBUNIT
(Escherichia
coli) 		4 / 7 THR A 121
ILE A  90
LEU A  11
PHE A  86
 None
 0.84A 4ejjD-2idoA:
undetectable		 4ejjD-2idoA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2ido DNA POLYMERASE III
EPSILON SUBUNIT
(Escherichia
coli) 		4 / 5 ARG A 159
ASP A  12
GLU A 173
VAL A  38
 TMP  A2001 ( 4.6A)
MN  A1001 (-2.6A)
None
None
 1.39A 4nkvB-2idoA:
undetectable		 4nkvB-2idoA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 2ido DNA POLYMERASE III
EPSILON SUBUNIT
HOT PROTEIN
(Escherichia
coli;
Escherichia
virus
P1) 		5 / 12 GLY A  34
LEU A  52
GLU A  85
PHE A  48
ILE B   6
 None
 1.20A 4pd5A-2idoA:
undetectable		 4pd5A-2idoA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ido HOT PROTEIN
(Escherichia
virus
P1) 		4 / 9 SER B  24
ALA B  27
GLU B  30
LEU B  63
 None
 0.98A 4xtaA-2idoB:
undetectable		 4xtaA-2idoB:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 2ido DNA POLYMERASE III
EPSILON SUBUNIT
(Escherichia
coli) 		4 / 6 GLY A  64
GLU A  61
PHE A  63
ILE A  31
 None
TMP  A2001 (-4.0A)
None
None
 0.96A 5kmfA-2idoA:
undetectable
5kmfC-2idoA:
undetectable		 5kmfA-2idoA:
19.59
5kmfC-2idoA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2ido DNA POLYMERASE III
EPSILON SUBUNIT
(Escherichia
coli) 		4 / 7 ALA A  93
PHE A  79
ILE A  33
ILE A 118
 None
 0.82A 6b5vA-2idoA:
undetectable
6b5vB-2idoA:
undetectable		 6b5vA-2idoA:
17.03
6b5vB-2idoA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2ido DNA POLYMERASE III
EPSILON SUBUNIT
(Escherichia
coli) 		4 / 6 SER A 130
TYR A 175
GLU A  94
THR A 179
 None
 1.19A 6djzA-2idoA:
undetectable		 6djzA-2idoA:
21.86