SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2idx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 2idx COB(I)YRINIC ACID
A,C-DIAMIDE
ADENOSYLTRANSFERASE
(Homo
sapiens) 		4 / 4 ARG A 191
ALA A 187
ALA A  95
GLU A  91
 None
 1.06A 1e7bA-2idxA:
undetectable		 1e7bA-2idxA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 2idx COB(I)YRINIC ACID
A,C-DIAMIDE
ADENOSYLTRANSFERASE
(Homo
sapiens) 		4 / 4 ARG A 191
ALA A 187
ALA A  95
GLU A  91
 None
 1.07A 1e7bB-2idxA:
3.3		 1e7bB-2idxA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2idx COB(I)YRINIC ACID
A,C-DIAMIDE
ADENOSYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ALA A 181
ALA A  99
LEU A 223
ILE A 117
LEU A 216
 None
 1.04A 1rg7A-2idxA:
undetectable		 1rg7A-2idxA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2idx COB(I)YRINIC ACID
A,C-DIAMIDE
ADENOSYLTRANSFERASE
(Homo
sapiens) 		6 / 12 LEU A  92
GLY A 125
VAL A  82
ASP A 123
LEU A 213
LEU A 216
 None
 1.48A 3cjtO-2idxA:
undetectable		 3cjtO-2idxA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2idx COB(I)YRINIC ACID
A,C-DIAMIDE
ADENOSYLTRANSFERASE
(Homo
sapiens) 		5 / 9 ALA A  95
GLY A  97
LEU A 121
LEU A 100
ILE A 117
 None
 1.21A 3wdmC-2idxA:
undetectable		 3wdmC-2idxA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2idx COB(I)YRINIC ACID
A,C-DIAMIDE
ADENOSYLTRANSFERASE
(Homo
sapiens) 		4 / 8 ALA A  85
GLY A 125
LEU A 128
LEU A 199
 None
 0.75A 4po0A-2idxA:
3.5		 4po0A-2idxA:
17.46