SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iec'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FBY_B_9CRB1500_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	2iec	UNCHARACTERIZED PROTEIN CONSERVED IN ARCHAEA (Methanopyrus kandleri)	5 / 12	ILE A 49 ALA A 52 ALA A 53 GLN A 56 VAL A 66	None	1.08A	1fbyB-2iecA: undetectable	1fbyB-2iecA: 19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XIU_A_9CRA201_1 (RXR-LIKE PROTEIN)	2iec	UNCHARACTERIZED PROTEIN CONSERVED IN ARCHAEA (Methanopyrus kandleri)	5 / 12	ILE A 49 ALA A 52 ALA A 53 GLN A 56 VAL A 66	None	1.00A	1xiuA-2iecA: undetectable	1xiuA-2iecA: 21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XIU_B_9CRB202_1 (RXR-LIKE PROTEIN)	2iec	UNCHARACTERIZED PROTEIN CONSERVED IN ARCHAEA (Methanopyrus kandleri)	5 / 12	ILE A 49 ALA A 52 ALA A 53 GLN A 56 VAL A 66	None	1.01A	1xiuB-2iecA: undetectable	1xiuB-2iecA: 21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AVV_E_MK1E902_4 (POL POLYPROTEIN)	2iec	UNCHARACTERIZED PROTEIN CONSERVED IN ARCHAEA (Methanopyrus kandleri)	3 / 3	ARG A 51 VAL A 66 GLY A 34	None	0.62A	2avvE-2iecA: undetectable	2avvE-2iecA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FAL_A_REAA501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	2iec	UNCHARACTERIZED PROTEIN CONSERVED IN ARCHAEA (Methanopyrus kandleri)	5 / 10	ILE A 49 ALA A 52 ALA A 53 GLN A 56 VAL A 66	None	1.13A	3falA-2iecA: undetectable	3falA-2iecA: 19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UAN_A_9CRA503_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	2iec	UNCHARACTERIZED PROTEIN CONSERVED IN ARCHAEA (Methanopyrus kandleri)	5 / 12	ILE A 49 ALA A 52 ALA A 53 GLN A 56 VAL A 66	None	0.99A	5uanA-2iecA: undetectable	5uanA-2iecA: 16.03

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FBY_B_9CRB1500_1","RETINOIC ACID RECEPTOR RXR-ALPHA","2iec","UNCHARACTERIZED PROTEIN CONSERVED IN ARCHAEA","Methanopyrus kandleri",5,"ILE A  49;ALA A  52;ALA A  53;GLN A  56;VAL A  66","None","1.08A","1fbyB-2iecA:undetectable","1fbyB-2iecA:19.51"],["1XIU_A_9CRA201_1","RXR-LIKE PROTEIN","2iec","UNCHARACTERIZED PROTEIN CONSERVED IN ARCHAEA","Methanopyrus kandleri",5,"ILE A  49;ALA A  52;ALA A  53;GLN A  56;VAL A  66","None","1.00A","1xiuA-2iecA:undetectable","1xiuA-2iecA:21.37"],["1XIU_B_9CRB202_1","RXR-LIKE PROTEIN","2iec","UNCHARACTERIZED PROTEIN CONSERVED IN ARCHAEA","Methanopyrus kandleri",5,"ILE A  49;ALA A  52;ALA A  53;GLN A  56;VAL A  66","None","1.01A","1xiuB-2iecA:undetectable","1xiuB-2iecA:21.37"],["2AVV_E_MK1E902_4","POL POLYPROTEIN","2iec","UNCHARACTERIZED PROTEIN CONSERVED IN ARCHAEA","Methanopyrus kandleri",3,"ARG A  51;VAL A  66;GLY A  34","None","0.62A","2avvE-2iecA:undetectable","2avvE-2iecA:20.00"],["3FAL_A_REAA501_1","RETINOIC ACID RECEPTOR RXR-ALPHA","2iec","UNCHARACTERIZED PROTEIN CONSERVED IN ARCHAEA","Methanopyrus kandleri",5,"ILE A  49;ALA A  52;ALA A  53;GLN A  56;VAL A  66","None","1.13A","3falA-2iecA:undetectable","3falA-2iecA:19.51"],["5UAN_A_9CRA503_1","RETINOIC ACID RECEPTOR RXR-ALPHA","2iec","UNCHARACTERIZED PROTEIN CONSERVED IN ARCHAEA","Methanopyrus kandleri",5,"ILE A  49;ALA A  52;ALA A  53;GLN A  56;VAL A  66","None","0.99A","5uanA-2iecA:undetectable","5uanA-2iecA:16.03"]]