SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iel'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2iel HYPOTHETICAL PROTEIN
TT0030
(Thermus
thermophilus) 		4 / 4 THR A  11
LEU A  17
LEU A  24
GLN A  27
 None
 1.22A 1fbmA-2ielA:
undetectable		 1fbmA-2ielA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 2iel HYPOTHETICAL PROTEIN
TT0030
(Thermus
thermophilus) 		5 / 12 GLN A 122
ALA A 123
LEU A 107
LEU A  85
SER A  83
 None
 1.24A 2nv4A-2ielA:
undetectable		 2nv4A-2ielA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 2iel HYPOTHETICAL PROTEIN
TT0030
(Thermus
thermophilus) 		5 / 10 PRO A  38
LEU A   5
ILE A  88
PRO A  84
SER A 105
 None
 1.43A 3iluB-2ielA:
undetectable
3iluE-2ielA:
undetectable		 3iluB-2ielA:
18.14
3iluE-2ielA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2iel HYPOTHETICAL PROTEIN
TT0030
(Thermus
thermophilus) 		5 / 11 LEU A  67
GLU A  23
LYS A  22
LEU A  21
LEU A  17
 None
 0.82A 4wg0B-2ielA:
undetectable
4wg0C-2ielA:
undetectable
4wg0D-2ielA:
undetectable		 4wg0B-2ielA:
20.69
4wg0C-2ielA:
20.69
4wg0D-2ielA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2iel HYPOTHETICAL PROTEIN
TT0030
(Thermus
thermophilus) 		4 / 7 GLU A  23
LYS A  22
LEU A  21
LEU A  67
 None
 0.66A 4wg0B-2ielA:
undetectable
4wg0C-2ielA:
undetectable		 4wg0B-2ielA:
20.69
4wg0C-2ielA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2iel HYPOTHETICAL PROTEIN
TT0030
(Thermus
thermophilus) 		5 / 11 LEU A  67
GLU A  23
LYS A  22
LEU A  21
LEU A  17
 None
 0.82A 4wg0D-2ielA:
undetectable
4wg0E-2ielA:
undetectable
4wg0F-2ielA:
undetectable		 4wg0D-2ielA:
20.69
4wg0E-2ielA:
20.69
4wg0F-2ielA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2iel HYPOTHETICAL PROTEIN
TT0030
(Thermus
thermophilus) 		5 / 11 LEU A  17
GLU A  23
LYS A  22
LEU A  21
LEU A  67
 None
 0.82A 4wg0C-2ielA:
undetectable
4wg0D-2ielA:
undetectable
4wg0E-2ielA:
undetectable		 4wg0C-2ielA:
20.69
4wg0D-2ielA:
20.69
4wg0E-2ielA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2iel HYPOTHETICAL PROTEIN
TT0030
(Thermus
thermophilus) 		5 / 11 LEU A  67
GLU A  23
LYS A  22
LEU A  21
LEU A  17
 None
 0.85A 4wg0F-2ielA:
undetectable
4wg0G-2ielA:
undetectable
4wg0H-2ielA:
undetectable		 4wg0F-2ielA:
20.69
4wg0G-2ielA:
20.69
4wg0H-2ielA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2iel HYPOTHETICAL PROTEIN
TT0030
(Thermus
thermophilus) 		5 / 11 LEU A  17
GLU A  23
LYS A  22
LEU A  21
LEU A  67
 None
 0.82A 4wg0E-2ielA:
undetectable
4wg0F-2ielA:
undetectable
4wg0G-2ielA:
undetectable		 4wg0E-2ielA:
20.69
4wg0F-2ielA:
20.69
4wg0G-2ielA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2iel HYPOTHETICAL PROTEIN
TT0030
(Thermus
thermophilus) 		5 / 11 LEU A  17
GLU A  23
LYS A  22
LEU A  21
LEU A  67
 None
 0.89A 4wg0G-2ielA:
undetectable
4wg0H-2ielA:
undetectable
4wg0I-2ielA:
undetectable		 4wg0G-2ielA:
20.69
4wg0H-2ielA:
20.69
4wg0I-2ielA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2iel HYPOTHETICAL PROTEIN
TT0030
(Thermus
thermophilus) 		4 / 7 LEU A  67
GLU A  23
LYS A  22
LEU A  21
 None
 0.80A 4wg0L-2ielA:
undetectable
4wg0M-2ielA:
undetectable		 4wg0L-2ielA:
20.69
4wg0M-2ielA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 2iel HYPOTHETICAL PROTEIN
TT0030
(Thermus
thermophilus) 		5 / 9 ARG A   3
LEU A   5
GLY A 101
LEU A 128
GLU A  91
 None
 1.24A 5dqfA-2ielA:
undetectable		 5dqfA-2ielA:
14.66