SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iew'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 2iew INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 326
TYR A  41
LEU A 117
ASP A 325
 None
 1.47A 1dz6A-2iewA:
undetectable		 1dz6A-2iewA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 2iew INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 219
LEU A 130
TYR A 218
LEU A 348
LEU A 240
 None
 1.16A 1e7wA-2iewA:
undetectable		 1e7wA-2iewA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 2iew INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 352
ILE A 167
TYR A 218
ILE A 129
LEU A 348
 None
 1.23A 1fm4A-2iewA:
undetectable		 1fm4A-2iewA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 2iew INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Saccharomyces
cerevisiae) 		4 / 5 LYS A 229
PHE A 124
LEU A 224
LEU A 259
 None
 1.40A 1skxA-2iewA:
undetectable		 1skxA-2iewA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 2iew INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 204
TYR A 186
GLY A 203
ARG A 206
 None
 0.76A 2f9wA-2iewA:
undetectable
2f9wB-2iewA:
undetectable		 2f9wA-2iewA:
20.69
2f9wB-2iewA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2iew INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 167
PHE A 236
PHE A 219
TYR A 218
 None
 1.11A 3elzB-2iewA:
undetectable		 3elzB-2iewA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 2iew INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A  29
PRO A  67
LEU A 260
ILE A 324
 None
 0.69A 4dtaB-2iewA:
3.7		 4dtaB-2iewA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2iew INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A 322
VAL A 341
PHE A 326
LEU A 117
LEU A 120
 None
 1.43A 4o8fB-2iewA:
undetectable		 4o8fB-2iewA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2iew INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 340
SER A 155
ILE A 167
GLY A 169
SER A 256
 None
 1.14A 4obwC-2iewA:
undetectable		 4obwC-2iewA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2iew INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Saccharomyces
cerevisiae) 		5 / 7 LEU A 240
PHE A 236
PHE A 352
LEU A 348
PHE A 165
 None
 1.38A 5b3sC-2iewA:
undetectable
5b3sJ-2iewA:
undetectable		 5b3sC-2iewA:
21.34
5b3sJ-2iewA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2iew INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Saccharomyces
cerevisiae) 		3 / 3 SER A 257
SER A 329
PHE A 243
 None
 0.94A 5mugA-2iewA:
undetectable		 5mugA-2iewA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2iew INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 126
PRO A 127
LYS A 171
 None
 1.16A 5y9yA-2iewA:
undetectable		 5y9yA-2iewA:
25.51