SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ifa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2ifa HYPOTHETICAL PROTEIN
SMU.260
(Streptococcus
mutans) 		4 / 7 PHE A  61
ASP A  57
TYR A 162
THR A  95
 None
 1.13A 2aouB-2ifaA:
undetectable		 2aouB-2ifaA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2ifa HYPOTHETICAL PROTEIN
SMU.260
(Streptococcus
mutans) 		4 / 7 ILE A  36
HIS A 149
VAL A 154
PHE A  99
 None
FMN  A 501 (-4.1A)
None
None
 1.11A 4a97H-2ifaA:
undetectable		 4a97H-2ifaA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ifa HYPOTHETICAL PROTEIN
SMU.260
(Streptococcus
mutans) 		4 / 6 GLN A 148
PHE A  61
LEU A  97
PHE A  99
 FMN  A 501 (-3.8A)
None
None
None
 1.00A 5b1bC-2ifaA:
undetectable
5b1bJ-2ifaA:
undetectable		 5b1bC-2ifaA:
18.96
5b1bJ-2ifaA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2ifa HYPOTHETICAL PROTEIN
SMU.260
(Streptococcus
mutans) 		5 / 11 PHE A 176
GLY A 144
ILE A 143
ILE A  32
ILE A 134
 None
 1.00A 6ebzB-2ifaA:
undetectable		 6ebzB-2ifaA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2ifa HYPOTHETICAL PROTEIN
SMU.260
(Streptococcus
mutans) 		5 / 11 PHE A 176
GLY A 144
ILE A 143
ILE A  32
ILE A 134
 None
 1.00A 6ebzC-2ifaA:
undetectable		 6ebzC-2ifaA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 2ifa HYPOTHETICAL PROTEIN
SMU.260
(Streptococcus
mutans) 		5 / 11 PHE A 176
GLY A 144
ILE A 143
ILE A  32
ILE A 134
 None
 0.99A 6gp2A-2ifaA:
undetectable		 6gp2A-2ifaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 2ifa HYPOTHETICAL PROTEIN
SMU.260
(Streptococcus
mutans) 		5 / 11 PHE A 176
GLY A 144
ILE A 143
ILE A  32
ILE A 134
 None
 0.94A 6gp2B-2ifaA:
undetectable		 6gp2B-2ifaA:
19.59