SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ifg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		3 / 3 LEU A 229
TRP A 227
GLY A 248
 None
 0.76A 3l35A-2ifgA:
undetectable
3l35H-2ifgA:
undetectable		 3l35A-2ifgA:
7.92
3l35H-2ifgA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		3 / 3 LEU A 229
TRP A 227
GLY A 248
 None
 0.76A 3l35B-2ifgA:
undetectable
3l35K-2ifgA:
undetectable		 3l35B-2ifgA:
7.92
3l35K-2ifgA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		3 / 3 GLN A 279
THR A 264
ASN A 262
 NAG  A 383 ( 4.8A)
None
NAG  A 383 (-2.0A)
 0.89A 3v4tE-2ifgA:
undetectable		 3v4tE-2ifgA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		4 / 4 TRP A 227
LEU A 213
LEU A 251
THR A 237
 None
 1.42A 4bboD-2ifgA:
0.0		 4bboD-2ifgA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		3 / 3 LEU A 232
GLU A 233
SER A 235
 None
 0.69A 4ccqA-2ifgA:
undetectable		 4ccqA-2ifgA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		3 / 3 LEU A 212
LEU A 232
ASN A 253
 None
 0.65A 4otwA-2ifgA:
undetectable		 4otwA-2ifgA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 8 ALA A 110
LEU A 103
LEU A  79
LEU A  96
LEU A 122
 None
 1.35A 5jqbA-2ifgA:
undetectable
5jqbB-2ifgA:
undetectable		 5jqbA-2ifgA:
19.57
5jqbB-2ifgA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 8 ALA A 110
LEU A 103
LEU A  79
LEU A 120
LEU A 122
 None
 1.14A 5jqbA-2ifgA:
undetectable
5jqbB-2ifgA:
undetectable		 5jqbA-2ifgA:
19.57
5jqbB-2ifgA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		4 / 8 HIS A 343
LEU A 333
GLY A 344
SER A 304
 None
 0.89A 5m8rC-2ifgA:
undetectable		 5m8rC-2ifgA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		3 / 3 TRP A 299
MET A 379
ASN A 356
 None
 1.06A 5uc1B-2ifgA:
undetectable		 5uc1B-2ifgA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		3 / 3 TRP A 299
MET A 379
ASN A 356
 None
 1.02A 5uc1A-2ifgA:
undetectable		 5uc1A-2ifgA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		3 / 3 GLU A  83
ASP A 109
PRO A 108
 None
 0.76A 6berA-2ifgA:
undetectable		 6berA-2ifgA:
2.31