SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ifu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 2ifu GAMMA-SNAP
(Danio
rerio) 		5 / 10 TYR A  37
HIS A  11
ALA A  38
ALA A  56
ALA A  41
 None
SO4  A 306 (-4.8A)
None
None
None
 1.44A 2r2vC-2ifuA:
undetectable
2r2vF-2ifuA:
undetectable
2r2vG-2ifuA:
undetectable		 2r2vC-2ifuA:
8.87
2r2vF-2ifuA:
8.87
2r2vG-2ifuA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 2ifu GAMMA-SNAP
(Danio
rerio) 		4 / 5 LEU A  87
LYS A  48
LEU A  50
GLU A  51
 None
 1.04A 3h5gA-2ifuA:
undetectable
3h5gB-2ifuA:
undetectable		 3h5gA-2ifuA:
7.54
3h5gB-2ifuA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 2ifu GAMMA-SNAP
(Danio
rerio) 		4 / 6 PHE A 143
ARG A 148
LEU A 155
GLU A 154
 None
SO4  A 307 (-4.1A)
None
None
 1.32A 3vlnA-2ifuA:
undetectable		 3vlnA-2ifuA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 2ifu GAMMA-SNAP
(Danio
rerio) 		3 / 3 LYS A  54
LEU A  84
ALA A  80
 None
 0.81A 4iizA-2ifuA:
undetectable		 4iizA-2ifuA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2ifu GAMMA-SNAP
(Danio
rerio) 		5 / 8 ALA A  93
ALA A 120
ALA A 116
ALA A 100
SER A 101
 None
 1.26A 4twdF-2ifuA:
undetectable
4twdG-2ifuA:
undetectable
4twdH-2ifuA:
undetectable
4twdI-2ifuA:
undetectable
4twdJ-2ifuA:
undetectable		 4twdF-2ifuA:
20.82
4twdG-2ifuA:
20.82
4twdH-2ifuA:
20.82
4twdI-2ifuA:
20.82
4twdJ-2ifuA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 2ifu GAMMA-SNAP
(Danio
rerio) 		4 / 7 LEU A 176
TYR A 183
GLY A 157
LYS A 158
 None
 1.00A 4z69A-2ifuA:
undetectable		 4z69A-2ifuA:
21.98