SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ifw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2ifw SCYTALIDOPEPSIN B
(Scytalidium
lignicola) 		6 / 10 ALA A  23
THR A  22
ALA A  21
VAL A 160
GLY A  55
ALA A  38
 None
 1.39A 2f16K-2ifwA:
undetectable
2f16L-2ifwA:
undetectable		 2f16K-2ifwA:
20.76
2f16L-2ifwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2ifw SCYTALIDOPEPSIN B
(Scytalidium
lignicola) 		6 / 10 ALA A  23
THR A  22
ALA A  21
VAL A 160
GLY A  55
ALA A  38
 None
 1.39A 2f16Y-2ifwA:
undetectable
2f16Z-2ifwA:
undetectable		 2f16Y-2ifwA:
20.76
2f16Z-2ifwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2ifw SCYTALIDOPEPSIN B
(Scytalidium
lignicola) 		6 / 12 ALA A  23
THR A  22
ALA A  21
VAL A 160
GLY A  55
ALA A  38
 None
 1.38A 3mg0Y-2ifwA:
undetectable
3mg0Z-2ifwA:
undetectable		 3mg0Y-2ifwA:
20.76
3mg0Z-2ifwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ifw SCYTALIDOPEPSIN B
(Scytalidium
lignicola) 		5 / 12 TYR A  59
ALA A  28
GLY A  62
GLY A  31
SER A  32
 None
 1.22A 3ou7A-2ifwA:
undetectable		 3ou7A-2ifwA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ifw SCYTALIDOPEPSIN B
(Scytalidium
lignicola) 		5 / 12 TYR A  59
ALA A  28
GLY A  62
GLY A  31
SER A  32
 None
 1.19A 3ou7D-2ifwA:
undetectable		 3ou7D-2ifwA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ifw SCYTALIDOPEPSIN B
(Scytalidium
lignicola) 		5 / 11 VAL A 206
TRP A  58
GLY A   7
GLY A   8
ILE A 181
 None
 1.15A 3owxA-2ifwA:
undetectable
3owxB-2ifwA:
undetectable		 3owxA-2ifwA:
21.40
3owxB-2ifwA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2ifw SCYTALIDOPEPSIN B
(Scytalidium
lignicola) 		4 / 8 SER A 102
THR A 104
SER A 115
SER A 117
 None
 0.55A 4ikkA-2ifwA:
undetectable
4ikkB-2ifwA:
undetectable		 4ikkA-2ifwA:
22.45
4ikkB-2ifwA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 2ifw SCYTALIDOPEPSIN B
(Scytalidium
lignicola) 		3 / 3 TRP A  39
GLN A  90
THR A  54
 None
 0.94A 4m2xA-2ifwA:
undetectable		 4m2xA-2ifwA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2ifw SCYTALIDOPEPSIN B
(Scytalidium
lignicola) 		5 / 12 GLY A  41
ILE A  10
ASN A 130
GLY A   8
SER A  20
 None
 1.05A 4obwC-2ifwA:
undetectable		 4obwC-2ifwA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2ifw SCYTALIDOPEPSIN B
(Scytalidium
lignicola) 		5 / 10 ALA A  23
THR A  22
ALA A  21
VAL A 160
GLY A  55
 None
 1.03A 4qvyK-2ifwA:
undetectable
4qvyL-2ifwA:
undetectable		 4qvyK-2ifwA:
21.19
4qvyL-2ifwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2ifw SCYTALIDOPEPSIN B
(Scytalidium
lignicola) 		5 / 10 ALA A  23
THR A  22
ALA A  21
VAL A 160
GLY A  55
 None
 1.03A 4qvyY-2ifwA:
undetectable
4qvyZ-2ifwA:
undetectable		 4qvyY-2ifwA:
21.19
4qvyZ-2ifwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2ifw SCYTALIDOPEPSIN B
(Scytalidium
lignicola) 		3 / 3 ASP A 190
ASN A 187
PHE A 150
 None
 0.75A 5dsgB-2ifwA:
undetectable		 5dsgB-2ifwA:
20.53