SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ify'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		5 / 11 THR A 462
GLY A 405
THR A 413
VAL A  24
VAL A 417
 None
 1.27A 1akdA-2ifyA:
0.8		 1akdA-2ifyA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		5 / 10 ILE A 255
LEU A 134
GLU A 138
LYS A 104
VAL A 103
 None
 1.11A 1cqpA-2ifyA:
undetectable
1cqpB-2ifyA:
2.1		 1cqpA-2ifyA:
17.59
1cqpB-2ifyA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 5 ASP A 402
HIS A 406
HIS A 444
HIS A 461
 MN  A 601 (-2.4A)
MN  A 601 (-3.6A)
MN  A 701 (-3.3A)
MN  A 601 (-3.4A)
 0.49A 1ei6A-2ifyA:
18.0		 1ei6A-2ifyA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		5 / 8 ASP A  11
ASP A 402
HIS A 406
HIS A 444
HIS A 461
 MN  A 701 (-2.4A)
MN  A 601 (-2.4A)
MN  A 601 (-3.6A)
MN  A 701 (-3.3A)
MN  A 601 (-3.4A)
 0.61A 1ei6C-2ifyA:
17.4		 1ei6C-2ifyA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		3 / 3 ASP A 252
PHE A 271
VAL A 205
 None
 0.78A 1kijB-2ifyA:
undetectable		 1kijB-2ifyA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		3 / 3 THR A 420
LEU A 424
VAL A 427
 None
 0.43A 1mz9E-2ifyA:
undetectable		 1mz9E-2ifyA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ND4_A_KANA1300_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		5 / 10 ASP A 191
ARG A 193
ARG A 263
ASP A 262
GLU A 230
 None
 1.36A 1nd4A-2ifyA:
0.0		 1nd4A-2ifyA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ND4_B_KANB2300_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		5 / 9 ASP A 191
ARG A 193
ARG A 263
ASP A 262
GLU A 230
 None
 1.33A 1nd4B-2ifyA:
0.0		 1nd4B-2ifyA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		3 / 3 ASP A 275
HIS A 287
ASP A 302
 None
 0.62A 1nw5A-2ifyA:
2.1		 1nw5A-2ifyA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		5 / 12 GLY A 484
MET A 502
ARG A 478
ILE A 395
PHE A 343
 None
 1.29A 1p93D-2ifyA:
undetectable		 1p93D-2ifyA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 6 VAL A 169
THR A 166
LEU A 132
PHE A 129
 None
 1.03A 1s8fB-2ifyA:
2.2		 1s8fB-2ifyA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 8 PHE A 271
ILE A 267
PHE A 291
GLY A 114
 None
 0.95A 2qwxA-2ifyA:
4.2
2qwxB-2ifyA:
4.3		 2qwxA-2ifyA:
19.13
2qwxB-2ifyA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 8 PHE A 271
ILE A 267
PHE A 291
GLY A 114
 None
 0.80A 2qx4A-2ifyA:
undetectable
2qx4B-2ifyA:
3.0		 2qx4A-2ifyA:
19.09
2qx4B-2ifyA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 6 PHE A 271
ILE A 267
PHE A 291
GLY A 114
 None
 0.79A 2qx6A-2ifyA:
4.2
2qx6B-2ifyA:
3.0		 2qx6A-2ifyA:
19.09
2qx6B-2ifyA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 8 ARG A 269
ILE A 267
GLY A 114
PHE A 113
 None
 0.89A 2tsrB-2ifyA:
undetectable		 2tsrB-2ifyA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		5 / 12 ALA A 442
GLY A 445
GLY A  59
LEU A 424
PRO A 467
 None
 0.97A 2y7hB-2ifyA:
3.0		 2y7hB-2ifyA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		5 / 12 ALA A 442
GLY A 445
GLY A  59
LEU A 424
PRO A 467
 None
 0.97A 2y7hC-2ifyA:
2.6		 2y7hC-2ifyA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		5 / 10 GLY A 405
ALA A 447
HIS A 406
HIS A 461
HIS A 444
 None
None
MN  A 601 (-3.6A)
MN  A 601 (-3.4A)
MN  A 701 (-3.3A)
 1.45A 3boyA-2ifyA:
0.0
3boyC-2ifyA:
0.0		 3boyA-2ifyA:
16.52
3boyC-2ifyA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		5 / 10 HIS A 461
HIS A 444
GLY A 405
ALA A 447
HIS A 406
 MN  A 601 (-3.4A)
MN  A 701 (-3.3A)
None
None
MN  A 601 (-3.6A)
 1.44A 3boyA-2ifyA:
0.0
3boyB-2ifyA:
0.0		 3boyA-2ifyA:
16.52
3boyB-2ifyA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA3001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		5 / 10 HIS A 461
HIS A 444
GLY A 405
ALA A 447
HIS A 406
 MN  A 601 (-3.4A)
MN  A 701 (-3.3A)
None
None
MN  A 601 (-3.6A)
 1.44A 3boyB-2ifyA:
0.0
3boyC-2ifyA:
0.0		 3boyB-2ifyA:
16.52
3boyC-2ifyA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 8 HIS A 461
HIS A 406
ASP A  11
GLY A  12
 MN  A 601 (-3.4A)
MN  A 601 (-3.6A)
MN  A 701 (-2.4A)
None
 0.92A 3c0zB-2ifyA:
undetectable		 3c0zB-2ifyA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		3 / 3 THR A 300
SER A 298
PHE A 291
 None
 0.75A 3d4sA-2ifyA:
undetectable		 3d4sA-2ifyA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 6 ILE A   8
MET A 490
ILE A 486
HIS A  65
 None
 1.19A 3eteA-2ifyA:
undetectable
3eteE-2ifyA:
undetectable		 3eteA-2ifyA:
21.49
3eteE-2ifyA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 5 ILE A   8
MET A 490
ILE A 486
HIS A  65
 None
 1.19A 3eteB-2ifyA:
2.1
3eteC-2ifyA:
undetectable		 3eteB-2ifyA:
21.49
3eteC-2ifyA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		3 / 3 ILE A 440
PHE A  13
HIS A  41
 None
 0.71A 3h0aA-2ifyA:
undetectable		 3h0aA-2ifyA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 8 GLY A 303
PHE A 291
ILE A 265
PHE A 113
 None
 0.95A 3ko0O-2ifyA:
undetectable
3ko0Q-2ifyA:
undetectable		 3ko0O-2ifyA:
10.94
3ko0Q-2ifyA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		5 / 10 THR A 462
GLY A 405
THR A 413
VAL A  24
VAL A 417
 None
 1.33A 3lxiA-2ifyA:
undetectable		 3lxiA-2ifyA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		5 / 12 ILE A  73
VAL A  51
GLY A  71
LEU A 483
ILE A 395
 None
 0.87A 3mb5A-2ifyA:
5.2		 3mb5A-2ifyA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		3 / 3 GLU A 278
PHE A 276
GLN A 266
 None
 0.74A 3r55A-2ifyA:
undetectable		 3r55A-2ifyA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		5 / 12 GLY A  71
GLY A 504
GLN A 498
LEU A 483
ALA A 487
 None
 1.23A 3sxjA-2ifyA:
3.6		 3sxjA-2ifyA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		5 / 12 GLY A  71
GLY A 504
GLN A 498
LEU A 483
ALA A 487
 None
 1.23A 3sxjB-2ifyA:
3.4		 3sxjB-2ifyA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_F_ACTF701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 4 PHE A 343
HIS A  65
GLY A  69
ILE A  68
 None
 1.40A 4k50E-2ifyA:
0.0		 4k50E-2ifyA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_M_ACTM503_0
(RNA POLYMERASE
3D-POL)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 4 PHE A 343
HIS A  65
GLY A  69
ILE A  68
 None
 1.41A 4k50M-2ifyA:
0.0		 4k50M-2ifyA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		3 / 3 ARG A 263
ASP A 191
ARG A 152
 None
 0.99A 4mx0A-2ifyA:
undetectable		 4mx0A-2ifyA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		5 / 12 ASP A 402
GLY A  12
GLY A 445
ALA A 460
GLY A  64
 MN  A 601 (-2.4A)
None
None
None
None
 0.84A 4n09B-2ifyA:
4.3		 4n09B-2ifyA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		5 / 12 ASP A 402
GLY A  12
GLY A 445
ALA A 460
GLY A  64
 MN  A 601 (-2.4A)
None
None
None
None
 0.86A 4n09C-2ifyA:
2.2		 4n09C-2ifyA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		5 / 12 ASP A 402
GLY A  12
GLY A 445
ALA A 460
GLY A  64
 MN  A 601 (-2.4A)
None
None
None
None
 0.84A 4n09D-2ifyA:
5.0		 4n09D-2ifyA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA304_1
(TYROSINASE)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 5 ASN A 446
HIS A 406
GLU A 450
THR A 413
 None
MN  A 601 (-3.6A)
None
None
 1.41A 4p6sA-2ifyA:
0.0		 4p6sA-2ifyA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 8 PHE A 271
ILE A 267
PHE A 291
GLY A 114
 None
 0.93A 4qogA-2ifyA:
4.3
4qogB-2ifyA:
4.3		 4qogA-2ifyA:
19.13
4qogB-2ifyA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 4 GLY A  59
VAL A  51
PHE A 343
ILE A  68
 None
 0.91A 4xv2B-2ifyA:
undetectable		 4xv2B-2ifyA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		5 / 12 GLY A  14
GLY A 445
GLU A  17
LEU A  10
LEU A  15
 None
 1.06A 5bw4A-2ifyA:
3.3		 5bw4A-2ifyA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		3 / 3 ASN A 397
LEU A 483
PHE A  13
 None
 0.65A 5dsgA-2ifyA:
undetectable		 5dsgA-2ifyA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		5 / 7 ASP A 402
GLY A 445
HIS A 461
HIS A  65
ASP A  11
 MN  A 601 (-2.4A)
None
MN  A 601 (-3.4A)
None
MN  A 701 (-2.4A)
 1.46A 5nnwD-2ifyA:
undetectable		 5nnwD-2ifyA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 8 VAL A 496
GLY A 317
LEU A 316
THR A 315
 None
 0.93A 5sxqA-2ifyA:
undetectable		 5sxqA-2ifyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 8 VAL A 496
GLY A 317
LEU A 316
THR A 315
 None
 0.89A 5sxtA-2ifyA:
undetectable		 5sxtA-2ifyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 8 VAL A 496
GLY A 317
LEU A 316
THR A 315
 None
 0.89A 5sxtB-2ifyA:
undetectable		 5sxtB-2ifyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 8 VAL A 496
GLY A 317
LEU A 316
THR A 315
 None
 0.92A 5syjB-2ifyA:
undetectable		 5syjB-2ifyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		3 / 3 TYR A 212
ALA A 147
LEU A 149
 None
 0.64A 6ag0C-2ifyA:
undetectable		 6ag0C-2ifyA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 6 GLY A  52
LEU A  53
PHE A 342
PHE A 341
 None
 1.03A 6h7lA-2ifyA:
undetectable		 6h7lA-2ifyA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Bacillus
anthracis) 		4 / 6 GLY A  52
LEU A  53
PHE A 342
PHE A 341
 None
 1.03A 6h7lB-2ifyA:
undetectable		 6h7lB-2ifyA:
9.60