SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ig8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Z0Y_A_SAMA300_0 (PUTATIVE UNCHARACTERIZED PROTEIN TTHA0657)	2ig8	HYPOTHETICAL PROTEIN PA3499 (Pseudomonas aeruginosa)	5 / 9	ALA A 11 LEU A 12 ILE A 7 LEU A 67 ALA A 66	None	0.89A	2z0yA-2ig8A: undetectable	2z0yA-2ig8A: 24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Z0Y_B_SAMB400_0 (PUTATIVE UNCHARACTERIZED PROTEIN TTHA0657)	2ig8	HYPOTHETICAL PROTEIN PA3499 (Pseudomonas aeruginosa)	5 / 9	ALA A 11 LEU A 12 ILE A 7 LEU A 67 ALA A 66	None	0.91A	2z0yB-2ig8A: undetectable	2z0yB-2ig8A: 24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EYR_B_RITB301_1 (HIV-1 PROTEASE)	2ig8	HYPOTHETICAL PROTEIN PA3499 (Pseudomonas aeruginosa)	4 / 7	LEU A 67 ALA A 130 VAL A 75 ILE A 94	None	0.96A	4eyrA-2ig8A: undetectable	4eyrA-2ig8A: 22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NKX_B_STRB601_1 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	2ig8	HYPOTHETICAL PROTEIN PA3499 (Pseudomonas aeruginosa)	5 / 12	LEU A 61 GLY A 95 ALA A 93 VAL A 126 VAL A 85	None	0.94A	4nkxB-2ig8A: undetectable	4nkxB-2ig8A: 14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VEU_A_RITA602_2 (CYTOCHROME P450 3A5)	2ig8	HYPOTHETICAL PROTEIN PA3499 (Pseudomonas aeruginosa)	3 / 3	ARG A 47 PHE A 121 LEU A 51	None	0.67A	5veuA-2ig8A: undetectable	5veuA-2ig8A: 15.37

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2Z0Y_A_SAMA300_0","PUTATIVE UNCHARACTERIZED PROTEIN TTHA0657","2ig8","HYPOTHETICAL PROTEIN PA3499","Pseudomonas aeruginosa",5,"ALA A  11;LEU A  12;ILE A   7;LEU A  67;ALA A  66","None","0.89A","2z0yA-2ig8A:undetectable","2z0yA-2ig8A:24.24"],["2Z0Y_B_SAMB400_0","PUTATIVE UNCHARACTERIZED PROTEIN TTHA0657","2ig8","HYPOTHETICAL PROTEIN PA3499","Pseudomonas aeruginosa",5,"ALA A  11;LEU A  12;ILE A   7;LEU A  67;ALA A  66","None","0.91A","2z0yB-2ig8A:undetectable","2z0yB-2ig8A:24.24"],["4EYR_B_RITB301_1","HIV-1 PROTEASE;HIV-1 PROTEASE","2ig8","HYPOTHETICAL PROTEIN PA3499","Pseudomonas aeruginosa",4,"LEU A  67;ALA A 130;VAL A  75;ILE A  94","None","0.96A","4eyrA-2ig8A:undetectable","4eyrA-2ig8A:22.38"],["4NKX_B_STRB601_1","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","2ig8","HYPOTHETICAL PROTEIN PA3499","Pseudomonas aeruginosa",5,"LEU A  61;GLY A  95;ALA A  93;VAL A 126;VAL A  85","None","0.94A","4nkxB-2ig8A:undetectable","4nkxB-2ig8A:14.20"],["5VEU_A_RITA602_2","CYTOCHROME P450 3A5","2ig8","HYPOTHETICAL PROTEIN PA3499","Pseudomonas aeruginosa",3,"ARG A  47;PHE A 121;LEU A  51","None","0.67A","5veuA-2ig8A:undetectable","5veuA-2ig8A:15.37"]]