SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2igf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z11_A_8MOA501_0 (CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 6)	2igf	IGG1-KAPPA B13I2 FAB (HEAVY CHAIN) (Mus musculus)	6 / 11	PHE H 29 ASN H 73 GLY H 54 THR H 57 ILE H 69 LEU H 78	None	1.45A	1z11A-2igfH: undetectable	1z11A-2igfH: 19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IEO_A_017A402_2 (PROTEASE)	2igf	IGG1-KAPPA B13I2 FAB (HEAVY CHAIN) (Mus musculus)	5 / 12	LEU H 140 VAL H 171 GLY H 164 VAL H 193 VAL H 191	None	0.91A	2ieoB-2igfH: undetectable	2ieoB-2igfH: 19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EM2_A_SALA501_1 (UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349)	2igf	IGG1-KAPPA B13I2 FAB (HEAVY CHAIN) (Mus musculus)	4 / 5	TYR H 90 LEU H 80 LEU H 82 ARG H 66	None	1.22A	4em2A-2igfH: undetectable	4em2A-2igfH: 21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CP4_A_CAMA422_0 (CYTOCHROME P450CAM)	2igf	IGG1-KAPPA B13I2 FAB (HEAVY CHAIN) (Mus musculus)	5 / 9	THR H 173 LEU H 124 GLY H 141 VAL H 210 VAL H 154	None	1.41A	5cp4A-2igfH: undetectable	5cp4A-2igfH: 18.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1Z11_A_8MOA501_0","CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 6","2igf","IGG1-KAPPA B13I2 FAB (HEAVY CHAIN)","Mus musculus",6,"PHE H  29;ASN H  73;GLY H  54;THR H  57;ILE H  69;LEU H  78","None","1.45A","1z11A-2igfH:undetectable","1z11A-2igfH:19.36"],["2IEO_A_017A402_2","PROTEASE;PROTEASE","2igf","IGG1-KAPPA B13I2 FAB (HEAVY CHAIN)","Mus musculus",5,"LEU H 140;VAL H 171;GLY H 164;VAL H 193;VAL H 191","None","0.91A","2ieoB-2igfH:undetectable","2ieoB-2igfH:19.02"],["4EM2_A_SALA501_1","UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349","2igf","IGG1-KAPPA B13I2 FAB (HEAVY CHAIN)","Mus musculus",4,"TYR H  90;LEU H  80;LEU H  82;ARG H  66","None","1.22A","4em2A-2igfH:undetectable","4em2A-2igfH:21.08"],["5CP4_A_CAMA422_0","CYTOCHROME P450CAM","2igf","IGG1-KAPPA B13I2 FAB (HEAVY CHAIN)","Mus musculus",5,"THR H 173;LEU H 124;GLY H 141;VAL H 210;VAL H 154","None","1.41A","5cp4A-2igfH:undetectable","5cp4A-2igfH:18.62"]]