SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2igi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 2igi OLIGORIBONUCLEASE
(Escherichia
coli) 		3 / 3 ARG A  23
TYR A 118
LYS A 117
 None
 0.97A 1uujB-2igiA:
undetectable		 1uujB-2igiA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C7V_B_MTXB1272_1
(PTERIDINE REDUCTASE)		 2igi OLIGORIBONUCLEASE
(Escherichia
coli) 		5 / 12 ASP A  81
PHE A 114
TYR A 118
LEU A  54
MET A  57
 None
 1.26A 2c7vB-2igiA:
undetectable		 2c7vB-2igiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C7V_C_MTXC1272_1
(PTERIDINE REDUCTASE)		 2igi OLIGORIBONUCLEASE
(Escherichia
coli) 		5 / 12 ASP A  81
PHE A 114
TYR A 118
LEU A  54
MET A  57
 None
 1.25A 2c7vC-2igiA:
undetectable		 2c7vC-2igiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_1
(PTERIDINE REDUCTASE)		 2igi OLIGORIBONUCLEASE
(Escherichia
coli) 		5 / 12 ASP A  81
PHE A 114
TYR A 118
LEU A  54
MET A  57
 None
 1.21A 2x9gA-2igiA:
undetectable		 2x9gA-2igiA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_B_LYAB1270_1
(PTERIDINE REDUCTASE)		 2igi OLIGORIBONUCLEASE
(Escherichia
coli) 		5 / 12 ASP A  81
PHE A 114
TYR A 118
LEU A  54
MET A  57
 None
 1.24A 2x9gB-2igiA:
0.1		 2x9gB-2igiA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_C_LYAC1270_1
(PTERIDINE REDUCTASE)		 2igi OLIGORIBONUCLEASE
(Escherichia
coli) 		5 / 12 ASP A  81
PHE A 114
TYR A 118
LEU A  54
MET A  57
 None
 1.20A 2x9gC-2igiA:
undetectable		 2x9gC-2igiA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_D_LYAD1270_1
(PTERIDINE REDUCTASE)		 2igi OLIGORIBONUCLEASE
(Escherichia
coli) 		5 / 12 ASP A  81
PHE A 114
TYR A 118
LEU A  54
MET A  57
 None
 1.20A 2x9gD-2igiA:
undetectable		 2x9gD-2igiA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9V_C_TMQC1270_1
(PTERIDINE REDUCTASE)		 2igi OLIGORIBONUCLEASE
(Escherichia
coli) 		5 / 10 ASP A  81
PHE A 114
TYR A 118
LEU A  54
MET A  57
 None
 1.33A 2x9vC-2igiA:
0.1		 2x9vC-2igiA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9V_D_TMQD1270_1
(PTERIDINE REDUCTASE)		 2igi OLIGORIBONUCLEASE
(Escherichia
coli) 		5 / 9 ASP A  81
PHE A 114
TYR A 118
LEU A  54
MET A  57
 None
 1.28A 2x9vD-2igiA:
0.2		 2x9vD-2igiA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 2igi OLIGORIBONUCLEASE
(Escherichia
coli) 		5 / 9 ASP A  58
THR A  15
ASN A  61
GLY A  16
ASP A  18
 None
 1.28A 3sfuA-2igiA:
undetectable		 3sfuA-2igiA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 2igi OLIGORIBONUCLEASE
(Escherichia
coli) 		5 / 9 ASP A  58
THR A  15
ASN A  61
GLY A  16
ASP A  18
 None
 1.28A 3sfuB-2igiA:
undetectable		 3sfuB-2igiA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 2igi OLIGORIBONUCLEASE
(Escherichia
coli) 		5 / 12 PHE A 126
THR A  29
LEU A  89
LEU A  12
LEU A 115
 None
 1.45A 4qynB-2igiA:
undetectable		 4qynB-2igiA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2igi OLIGORIBONUCLEASE
(Escherichia
coli) 		4 / 8 ASP A 111
HIS A  65
ASP A 162
GLU A 165
 CD  A1002 ( 3.9A)
None
ZN  A1001 ( 3.0A)
None
 1.24A 6mn4C-2igiA:
undetectable		 6mn4C-2igiA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2igi OLIGORIBONUCLEASE
(Escherichia
coli) 		4 / 8 ASP A 111
HIS A  65
GLU A  13
GLU A 165
 CD  A1002 ( 3.9A)
None
ZN  A1001 ( 2.5A)
None
 1.27A 6mn4C-2igiA:
undetectable		 6mn4C-2igiA:
22.95